ChemicalBook >> CAS DataBase List >>RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE

CAS No.
185246-32-6
Chemical Name:
RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE
Synonyms
Rp 8 Br PET cGMPS,Rp8BrPETcGMPS;Rp-8-bromo-PET-Cyclic GMPS sodium;Rp-8-bromo-PET-Cyclic GMPS (sodium salt);RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'...;Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate;Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt;RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE;Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3μ:5μ-cyclic monophosphorothioate hydrate sodium salt;Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt >=98% (HPLC), powder;Rp-8-Br-PET-cGMPS hydrate, Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3μ,5μ-cyclic monophosphorothioate hydrate sodium salt
CBNumber:
CB3972375
Molecular Formula:
C18H14BrN5NaO6PS
Molecular Weight:
562.266
MDL Number:
MOL File:
185246-32-6.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Properties

Melting point 240-300 °C(lit.)
storage temp. -20°C
solubility H2O: soluble15mg/mL at ≤60°C
form powder
color white to beige
FDA UNII 9QQM5R5DWL

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B6684 Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt ≥98% (HPLC), powder 185246-32-6 1mg $333 2024-03-01 Buy
Sigma-Aldrich B6684 Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt ≥98% (HPLC), powder 185246-32-6 5mg $1070 2024-03-01 Buy
Cayman Chemical 18823 Rp-8-bromo-PET-Cyclic GMPS (sodium salt) ≥99% 185246-32-6 1mg $267 2024-03-01 Buy
Cayman Chemical 18823 Rp-8-bromo-PET-Cyclic GMPS (sodium salt) ≥99% 185246-32-6 5mg $1063 2024-03-01 Buy
TRC R700933 Rp-8-Br-PET-cyclicGMPSSodiumSalt 185246-32-6 2.5μmol $265 2021-12-16 Buy
Product number Packaging Price Buy
B6684 1mg $333 Buy
B6684 5mg $1070 Buy
18823 1mg $267 Buy
18823 5mg $1063 Buy
R700933 2.5μmol $265 Buy

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Chemical Properties,Uses,Production

Description

Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM). It less potently inhibits protein kinase A (Ki = 11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50 = 25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki = 1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.

Uses

Rp-8-Br-PET-cyclic GMPS Sodium Salt is a competitive inhibitor of cGMP-dependent protein kinase (cGKI).

Biochem/physiol Actions

Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki?=?30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50?=?25 micromoles).

storage

Store at -20°C

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
BOC Sciences -- info@bocsci.com USA 0 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44894 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3μ:5μ-cyclic monophosphorothioate hydrate sodium salt Rp-8-Br-PET-cGMPS hydrate, Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3μ,5μ-cyclic monophosphorothioate hydrate sodium salt Rp-8-bromo-PET-Cyclic GMPS (sodium salt) Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt >=98% (HPLC), powder Rp-8-bromo-PET-Cyclic GMPS sodium Rp 8 Br PET cGMPS,Rp8BrPETcGMPS RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'... 185246-32-6 C18H14N5O6PSBrNa C18H16BrN5NaO6PS