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ChemicalBook >> CAS DataBase List >>1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-

1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-

1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- Structure
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- structure
CAS No.
169514-76-5
Chemical Name:
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-
Synonyms
Aza-T-dCyd;5-Aza-4-thio-2-deoxycytidine;4'-thio-5-aza-2-deoxycytidine;4-Amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one;1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-
CBNumber:
CB39783514
Molecular Formula:
C8H12N4O3S
Molecular Weight:
244.27
MDL Number:
MOL File:
169514-76-5.mol
Last updated:2025-04-17 18:22:24
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1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- Properties

Boiling point 495.4±55.0 °C(Predicted)
Density 1.91±0.1 g/cm3(Predicted)
pka 13.95±0.60(Predicted)
form Solid
color White to off-white
FDA UNII U2PTN0RZF6

1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- Chemical Properties,Uses,Production

Uses

2'-Deoxy-4'-thio-5-azacytidine-15N4 is an isotopic labelled compound of 2'-Deoxy-4'-thio-5-azacytidine (D211885). 2'-Deoxy-4'-thio-5-azacytidine is used in the preparation of 5-azacytosine nucleosides with potential anticancer properties.

in vivo

5-Aza-4'-thio-2'-deoxycytidine (6.7, 10 mg/kg/day; IP; for 9 days) is effective against NCI-H23 tumor xenografts[1].
5-Aza-4'-thio-2'-deoxycytidine (5 mg/kg/day; IP; for 9 days) decreases DNMT1 levels in tumors of CCRF-CEM tumors mice xenografts[1].
5-Aza-4'-thio-2'-deoxycytidine (1.5 mg/kg; ip; QD×5 rest and repeat 3 cycles) provides modest suppression of tumor growth as well in the HCT116 colon carcinoma, OVCAR3 ovarian tumor xenograft model. 5-Aza-4'-thio-2'-deoxycytidine has minimal antitumor effect in the HL-60 leukemia xenografts[2].

Animal Model:Young female athymic nu/nu mice with NCI-H23 tumor fragment[1]
Dosage:6.7 or 10 mg/kg
Administration:IP; daily for 9 days
Result:Had antitumor efficacy against NCI-H23 tumor xenografts.

IC 50

DNMT1

1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
NewCan Biotech Limited 		+86-0571-86912261 +8613735419629 sales@newcanbio.com China 9985 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3479 58
Zhengzhou Chemprize Biotech Co., Ltd. 15981919713 15981919713 sales@nucleosides.com China 408 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139 orders@jknbiochem.com China 6204 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 26071 58
Supplier Advantage
NewCan Biotech Limited 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Zhengzhou Chemprize Biotech Co., Ltd. 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58

View Lastest Price from 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4'-thio-5-aza-2-deoxycytidine pictures 2025-04-02 4'-thio-5-aza-2-deoxycytidine
169514-76-5
 US $0.00-0.00 / g 1g 97% 1kg NewCan Biotech Limited
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- 5-Aza-4-thio-2-deoxycytidine Aza-T-dCyd 4-Amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one 4'-thio-5-aza-2-deoxycytidine 169514-76-5