Minodronic acid
- CAS No.
- 180064-38-4
- Chemical Name:
- Minodronic acid
- Synonyms
- BPH 261;Bonoteo;Recalbon;ONO 5920;Nsc725590;Minodronicaci;Mino phosphate;Minodronic Acid;Minodronic acid (anhydrous);(127657-42-5) minodronic acid
- CBNumber:
- CB41011573
- Molecular Formula:
- C9H12N2O7P2
- Molecular Weight:
- 322.15
- MDL Number:
- MFCD00890772
- MOL File:
- 180064-38-4.mol
- MSDS File:
- SDS
| Density | 1.97±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Aqueous Base (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 1.48±0.10(Predicted) |
| color | White to Off-White |
| FDA UNII | 40SGR63TGL |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
Minodronic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M344900 | MinodronicAcid | 180064-38-4 | 10mg | $80 | 2021-12-16 | Buy |
| TRC | M344900 | MinodronicAcid | 180064-38-4 | 250mg | $350 | 2021-12-16 | Buy |
| Matrix Scientific | 100293 | (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid 95+% | 180064-38-4 | 1g | $348 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009219 | MINODRONATE 95.00% | 180064-38-4 | 10MG | $225.75 | 2021-12-16 | Buy |
| Matrix Scientific | 100293 | (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid 95+% | 180064-38-4 | 500mg | $226 | 2021-12-16 | Buy |
Minodronic acid Chemical Properties,Uses,Production
Description
Minodronic acid hydrate, a third-generation bisphosphonate, was
approved and launched in Japan for the oral treatment of
osteoporosis. Osteoporosis is a skeletal disorder characterized by low bone mass and structural deterioration of bone tissue resulting in bone
fragility and increased susceptibility to fractures, particularly of the hip,
spine, and wrist. It is the most common type of metabolic bone disease
and a major health concern affecting 200 million women worldwide.
Minodronic acid is the newest nitrogen-containing bisphosphonate to reach the market. In vitro, it inhibits
recombinant human FPP synthase activity with similar potency as zoledronic acid (IC50 = 3 nM for both agents).
The most common adverse events associated with minodronic acid included stomach and abdominal discomfort, abdominal pain, decrease in blood calcium level, and gastritis. The chemical synthesis of minodronic acid starts with a condensation reaction of 2-aminopyridine with ethyl 4-bromo-3-oxobutyrate by means of sodium bicarbonate to produce 2-(imidazo[1,2-a]pyridin-3-yl)acetic acid ethyl ester, which is hydrolyzed to the corresponding carboxylic acid with potassium hydroxide. Treatment of the carboxylic acid intermediate with phosphorus acid and phosphorus trichloride followed by hydrolysis with hydrochloric acid gives minodronic acid.
Originator
Astellas Pharma (Japan)
Uses
Minodronic acid is developed for osteoporosis treatment.
brand name
Recalbon, Bonoteo
Minodronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 1696 | 58 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
View Lastest Price from Minodronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | Minodronic acid
180064-38-4
|
US $50.00 / kg | 1kg | 99.10% | 50000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2023-08-15 | Minodronic acid
180064-38-4
|
US $50.00 / kg | 1kg | 99.9% | 10000MT | Henan Bao Enluo International TradeCo.，LTD | |
 |
2023-07-28 | Minodronic acid
180064-38-4
|
US $0.00 / kg | 1kg | 99% | 1000tons | Hebei Mojin Biotechnology Co., Ltd |
-
- Minodronic acid
180064-38-4
- US $50.00 / kg
- 99.10%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Minodronic acid
180064-38-4
- US $50.00 / kg
- 99.9%
- Henan Bao Enluo International TradeCo.，LTD
-
- Minodronic acid
180064-38-4
- US $0.00 / kg
- 99%
- Hebei Mojin Biotechnology Co., Ltd