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LACOSAMIDE

Description Generic formulation Indications Dose titration Uses Cautions Interactions Special populations Behavioural and cognitive effects in patients with epilepsy Psychiatric use References
LACOSAMIDE
LACOSAMIDE
CAS No.
175481-36-4
Chemical Name:
LACOSAMIDE
Synonyms
ViMpat;SPM 927;Erlosamide;ADD 243037;LACOSAMIDE;Harkoseride;Lacosamide solution;Lacosamide-d3 (Acetyl-d3);LacosaMide (1.0Mg/ML in Acetonitrile);(R)-2-Acetamido-N-benzyl-3-methoxypropanamide
CBNumber:
CB41011740
Molecular Formula:
C13H18N2O3
Formula Weight:
250.29362
MOL File:
175481-36-4.mol

LACOSAMIDE Properties

Melting point:
141-143?C
alpha 
D23 +16.0° (c = 1 in CH3OH)
Flash point:
2℃
storage temp. 
Refrigerator
InChIKey
VPPJLAIAVCUEMN-GFCCVEGCSA-N
CAS DataBase Reference
175481-36-4
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,Xn
Risk Statements  11-20/21/22-36
Safety Statements  16-26-36/37
RIDADR  UN 1648 3 / PGII
WGK Germany  2
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

LACOSAMIDE price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L-029 Lacosamide solution 1.0mg/mL in acetonitrile, ampule of 1mL, certified reference material 175481-36-4 029-1ml $144 2018-11-20 Buy
Cayman Chemical 10012592 Lacosamide ≥98% 175481-36-4 5mg $39 2018-11-19 Buy
Cayman Chemical 10012592 Lacosamide ≥98% 175481-36-4 10mg $70 2018-11-19 Buy
Cayman Chemical 10012592 Lacosamide ≥98% 175481-36-4 25mg $124 2018-11-19 Buy
Cayman Chemical 10012592 Lacosamide ≥98% 175481-36-4 50mg $228 2018-11-19 Buy

LACOSAMIDE Chemical Properties,Uses,Production

Description

Lacosamide (LCM), (SPM 927, (R)-2-acetamido-N-benzyl-3-methoxypropionamide, previously referred to as harkoseride or ADD 234037) is a member of a series of functionalized amino acids that were specifically synthesized as anticonvulsant or antiepileptic drug. It reduces the spread of seizure activity in the brain. Lacosamide appears to have a dual mode of action: selective enhancement of sodium channel inactivation and modulation of collapsin response mediator protein-2.  Compared to novel antiepileptic drugs, lacosamide has broader and higher efficacy, better tolerability, and improved pharmacokinetic properties. Lacosamide is in phase III clinical development for adjunctive treatment of patients with uncontrolled partial-onset seizures, and for monotherapy of patients with painful diabetic neuropathy. It is absorbed rapidly and completely after oral administration. Lacosamide has an elimination half-life of approximately 13 hours and a low potential for drug interactions. Additionally, lacosamide exhibits linear, dose-proportional pharmacokinetics with low intra- and interpatient variability.
Lacosamide (licensed in 2008) is a third- generation AED known with the proprietary brand name of Vimpat® (UCB Pharma, Slough) in the UK and USA.

Generic formulation

MHRA/ CHM advice to minimize risk when switching patients with epilepsy between different manufacturers’ products (incl. generic products):

Indications

Epilepsy: Adjunctive treatment of focal seizures with or without secondary generalization.

Dose titration

Uses

Lacosamide is an anticonvulsant and analgesic compound used for the treatment of partial-onset seizures and neuropathic pain. It can also used for the treatment of status epilepticus. Its analgesic effect is mediated by its inhibitory effect on sodium channels, which leads to neural membrane depolarization. Its interaction with the collapsin-response mediator protein 2 (CRMP-2 alias DRP-2) may also facilitate the above process, although the detailed mechanism remains to be elucidated. 

Cautions

Interactions

With AEDs
Concomitant treatment with other AEDs known to be enzyme inducers (such as carbamazepine, phenobarbital, phenytoin) decreases the overall systemic exposure of lacosamide by 25%.

With other drugs
Nil.

With alcohol/food

Special populations

Hepatic impairment
Renal impairment
Pregnancy

Behavioural and cognitive effects in patients with epilepsy

For this third- generation agent, clinical experience is still limited and little is known about its positive and negative psychotropic properties and their implications for the management of behavioural symptoms in patients with epilepsy. There are initial reports of depression, irritability and agitation, and psychotic symptoms. Reports of cognitive effects (mainly affecting attention and memory) are rare and usually not severe.

Psychiatric use

Lacosamide has no indications for the treatment of psychiatric disorders. There is insufficient experience with lacosamide to draw any conclusion regarding its psychotropic profile.

References

[1] B. K. Beyreuther, J. Freitag, C. Heers, N. Krebsfänger, U. Scharfenecker, T. Stöhr (2007) Lacosamide: a review of preclinical properties, CNS Drug Reviews, 13, 21-42
[2] Beyreuther, Bettina K., et al. "Lacosamide: A Review of Preclinical Properties." Cns Drug Reviews 13.1(2007):21.
[3]Chung, S, et al. "Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial." Epilepsia 51.6(2010):958–967.
[4]Kellinghaus, C, et al. "Intravenous lacosamide for treatment of status epilepticus." Acta Neurologica Scandinavica 123.2(2011):137–141.

Chemical Properties

White to Off-White Solid

Uses

A potent anticonvulsant.

LACOSAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products


LACOSAMIDE Suppliers

Global( 155)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
025-84209270 wgp@nanjing-pharmaceutical.com CHINA 117 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2549 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 663 60
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 956 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
sales@zetchem.com CHINA 1260 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816
86-0311-83975816 lisa@hbhuanhao.com CHINA 651 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20001 58
Suzhou Huihe Pharmaceutical Co. Ltd. 86-0512-88819360/88985990
86-0512-86876095 asynderm@163.com China 90 60

View Lastest Price from LACOSAMIDE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-11-06 Lacosamide
175481-36-4
US $1226.00-150.00 / G 10G 99.7%+ 600kg/month Hebei Huanhao Biotechnology Co., Ltd.
2018-08-16 LACOSAMIDE
175481-36-4
US $7.00 / KG 1KG 99% 1000KG career henan chemical co
2018-07-24 LACOSAMIDE
175481-36-4
US $100.00 / KG 100G 98% 500KG career henan chemical co

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