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Tulathromycin A

Tulathromycin A Structure
Tulathromycin A structure
CAS No.
217500-96-4
Chemical Name:
Tulathromycin A
Synonyms
CS-2009;Draxxin;CP 472295;Teramycin;Tulamycin;Tulathrmycin A;TULATHROMYCIN A;Unii-897A3kn7ap;Tulathromycin A, >=95%;Tulathromycin isomer mix
CBNumber:
CB41011760
Molecular Formula:
C41H79N3O12
Molecular Weight:
806.09
MDL Number:
MFCD09838804
MOL File:
217500-96-4.mol
Last updated:2023-12-21 17:48:05
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Tulathromycin A Properties

Melting point 186-188oC
Boiling point 853.8±65.0 °C(Predicted)
Density 1.17
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 13.19±0.70(Predicted)
color White to Off-White
FDA UNII 897A3KN7AP

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H412-H317
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P273-P501-P264-P280-P305+P351+P338-P337+P313P
NFPA 704
0
2 0

Tulathromycin A price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2107 Tulathromycin A ≥95% (HPLC) 217500-96-4 10MG $91.6 2024-03-01 Buy
Sigma-Aldrich SML2107 Tulathromycin A ≥95% (HPLC) 217500-96-4 50MG $371 2024-03-01 Buy
Cayman Chemical 19202 Tulathromycin A ≥95% 217500-96-4 5mg $57 2024-03-01 Buy
Cayman Chemical 19202 Tulathromycin A ≥95% 217500-96-4 10mg $89 2024-03-01 Buy
Cayman Chemical 19202 Tulathromycin A ≥95% 217500-96-4 25mg $208 2024-03-01 Buy
Product number Packaging Price Buy
SML2107 10MG $91.6 Buy
SML2107 50MG $371 Buy
19202 5mg $57 Buy
19202 10mg $89 Buy
19202 25mg $208 Buy

Tulathromycin A Chemical Properties,Uses,Production

Description

Tulathromycin A, marketed as Draxxin by Pfizer Inc., is a triamide antibiotic used for the treatment of respiratory diseases in cattle and pigs. It exists as a balanced mixture of two isomers, Tulathromycin A (90%) and B (10%). Tulathromycin is an antimicrobial agent of a macrolide, a 15-membered macrolide structure that is considered a triamide macrolide with three charged nitro groups.

Chemical Properties

Tulathromycin is a semi-synthetic macrolide antibiotic of the sub-class triamilide. It occurs as a white to off-white crystalline powder that is readily soluble in water at pH less than 8. At a pH of 7.4 (physiological pH), tulathromycin (a weak base) is 50 times more soluble in hydrophilic than hydrophobic media.

Uses

Tulathromycin A is used for the treatment of pulmonary diseases in pigs and cattle.
In cattle, tulathromycin is used for the treatment of rinderpest caused by Haemolytic rinderpest, polyvalent rinderpest and Haemophilus somnus (formerly Haemophilus somnus). It is also effective in the treatment of infections caused by Mycoplasma bovis. When used in high-risk calves, it is also used to prevent infections caused by these pathogens. It is also used for the treatment of bovine foot rot (interdigital necrotizing fungal disease) associated with Fusarium necrophorum and Fusarium oxysporum. A single dose is effective in bovine infectious keratoconjunctivitis (Mycobacterium bovis).
In pigs, it is used to control and treat SRD associated with Actinobacillus pleuropneumoniae, Bacteroides multilocularis, Bordetella bronchiseptica, Mycoplasma pneumoniae, and Haemophilus parasiticus, and tulathromycin has been used to treat lung abscesses.

Definition

ChEBI:Tulathromycin A is an aminoglycoside.

Biological Activity

Tulathromycin, like other macrolides, exerts therapeutic benefits not solely explainable by antibacterial activity. Like azithromycin, tulathromycin A may have multiple immunomodulatory effects that likely contribute to the therapeutic response in respiratory infections and perhaps other diseases[1]. Other beneficial effects may be caused by enhanced degranulation and apoptosis of neutrophils and inhibition of inflammatory cytokine production. It also may help clear infections by enhancing macrophage functions.

Pharmacokinetics

The half-life is long, with 80- to 90-hour plasma half-life in pigs and cattle, and 8- and 6-day tissue half-life in cattle and pigs, respectively, which prolongs the drug concentration at the site of infection. The volume of distribution is greater than 10 L/kg. Absorption from injection is greater than 80% in cattle and pigs. Tulathromycin A concentrates in bronchoalveolar cells, and concentrations are detectable for at least 8 days after a single administration, although they are still lower than the MIC for R. equi (greater than 64 μg/mL)[1-2].

Mode of action

Tulathromycin A is a macrolide antibiotic. It binds to the subunit 50S of the bacterial ribosome, interfering with bacterial protein synthesis.

References

[1] Mark G, et al. Tulathromycin. Papich Handbook of Veterinary Drugs (Fifth Edition), 2021; 949-951.
[2] Jennifer L, et al. Pharmacologic Principles. Equine Internal Medicine (Fourth Edition), 2018; 79-137.

Tulathromycin A Preparation Products And Raw materials

Raw materials

Preparation Products

Tulathromycin A Suppliers

Global( 257)Suppliers
Supplier Tel Email Country ProdList Advantage
Masteam Bio-tech Co., Ltd. 		+86-15200345168 +86-15200345168 bruce.lei@masteam.com CHINA 153 58
Sinoway Industrial co., ltd. 		0592-5800732; +8613806035118 xie@china-sinoway.com China 992 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2141 58
Casorganics US Corp 		+17326109938 sales@casorganics.com CHINA 174 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8823 58
Supplier Advantage
Masteam Bio-tech Co., Ltd. 		58
Sinoway Industrial co., ltd. 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Casorganics US Corp 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58

Related articles

View Lastest Price from Tulathromycin A manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tulathromycin pictures 2024-04-22 Tulathromycin
217500-96-4
 US $260.00-160.00 / Kg/Bag 1Kg/Bag 95% up, Vet-GMP 20tons Sinoway Industrial co., ltd.
Tulathromycin A pictures 2023-12-06 Tulathromycin A
217500-96-4
 US $0.00-0.00 / kg 1kg 99% 50000kg Hebei Yibangte Import and Export Co. , Ltd.
Tulathromycin A pictures 2023-09-20 Tulathromycin A
217500-96-4
 US $0.00 / kg 1kg 0.99 20tons Hebei Yanxi Chemical Co., Ltd.
  • Tulathromycin pictures
  • Tulathromycin
    217500-96-4
  • US $260.00-160.00 / Kg/Bag
  • 95% up, Vet-GMP
  • Sinoway Industrial co., ltd.
  • Tulathromycin A pictures
  • Tulathromycin A
    217500-96-4
  • US $0.00-0.00 / kg
  • 99%
  • Hebei Yibangte Import and Export Co. , Ltd.

217500-96-4(Tulathromycin A)Related Search:

Diclazuril TULATHROMYCIN B,Tulathromycin Bensulfuron methyl Thiophanate-methyl Methylparaben
METSULFURON METHYL Azithromycin Methyl acetate Gentamicin Clindamycin
Methyl acrylate Kresoxim-methyl Telithromycin Tiamulin Tylosin
Tiamulin fumarate Methyl [2H9]-Tulobuterol, racemic mixture

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TULATHROMYCIN A (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-a-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one Unii-897A3kn7ap (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-Methyl-3-O-Methyl-4-C-[(propylaMino)Methyl]-α-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexaMethyl-11-[[3,4,6-trideoxy-3-(diMethylaMino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one CP 472295 Draxxin Tulathromycin A, >=95% Tulathrmycin A Tulathromycin A Solution, 1000ppm Tulathromycin，Tulathromycin A CS-2009 (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one Tulathromycin isomer mix pharmaceutical ingredient TULATHROMYCIN A 1-Oxa-6-azacyclopentadecan-15-one, 13-[[2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-α-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- Tulathromycin A USP/EP/BP Tulathromycin A (CP 472295) (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-((propylamino)methyl)tetrahydro-2H-pyran-2-yl)oxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one Teramycin Tulamycin 217500-96-4 C41H79N3O12 API Carbohydrates & Derivatives Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals 217500-96-4