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SUBSTANCE P

CAS No.
33507-63-0
Chemical Name:
SUBSTANCE P
Synonyms
Sub;TYR8;RPKPQFFGLM;Aids114081;SUBSTANCE P;P substance;Aids-114081;Neurokinin P;RPKPQQFFGLM-NH2;substance P (SP)
CBNumber:
CB4114260
Molecular Formula:
C63H98N18O13S
Molecular Weight:
1347.63
MDL Number:
MFCD00076780
MOL File:
33507-63-0.mol
Last updated:2024-03-27 11:49:37

SUBSTANCE P Properties

Melting point 148 °C
Density 1.42±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility H2O: 1 mg/mL
pka 13.26±0.46(Predicted)
form powder
color white
Water Solubility Soluble in water, DMSO, and Acetic Acid.
Sequence H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
InChIKey ADNPLDHMAVUMIW-UHFFFAOYSA-N
FDA UNII 675VGV5J1D

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H312-H332-H302
Precautionary statements  P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501
WGK Germany  3
3-10-21

SUBSTANCE P price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 05-23-0600 Substance P - CAS 33507-63-0 - Calbiochem Neuropeptidefoundinhighconcentrationsinthegut. 33507-63-0 1mg $69 2024-03-01 Buy
Sigma-Aldrich 05-23-0600 Substance P - CAS 33507-63-0 - Calbiochem Neuropeptide found in high concentrations in the gut. 33507-63-0 5MG $208 2024-03-01 Buy
Sigma-Aldrich 05-23-0600 Substance P - CAS 33507-63-0 - Calbiochem Neuropeptide found in high concentrations in the gut. 33507-63-0 25MG $560 2024-03-01 Buy
Alfa Aesar J63489 Substance P 33507-63-0 5mg $172 2023-06-20 Buy
Alfa Aesar J63489 Substance P 33507-63-0 25mg $675 2023-06-20 Buy
Product number Packaging Price Buy
05-23-0600 1mg $69 Buy
05-23-0600 5MG $208 Buy
05-23-0600 25MG $560 Buy
J63489 5mg $172 Buy
J63489 25mg $675 Buy

SUBSTANCE P Chemical Properties,Uses,Production

Uses

Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.

Definition

ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).

General Description

Substance P is a polypeptide consisting of 11 amino acidresidues. It has been implicated in the transmission of“painful” sensory information through the spinal cord tohigher centers in the central nervous system. Substance Pis localized in the primary afferent sensory fibers. Other pharmacologicaleffects are vasodilatation, stimulation of smoothmuscles, stimulation of salivary secretion, and diuresis. In addition,this neuropeptide contributes to some inflammatory responses.Approximately 50% of the known neuropeptides aresynthesized as biologically inactive glycine extended precursorsthat require a carboxy-terminal posttranslational amidationfor biological activity. Amidation enzymes are responsiblefor the conversion of the carboxyl group of the neuropeptide tothe corresponding amide group and include the two amidatingenzymes peptidylglycine α-monooxygenase (PAM) and peptidylamidoglycolatelyase (PGL), which work sequentially toproduce the inflammatory neuropeptide Substance P from aninactive precursor peptide. Much research is being performedto exploit this mechanism of inflammation.

storage

-20°C

SUBSTANCE P Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 173)Suppliers
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BOC Sciences
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Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Chengdu Youngshe Chemical Co., Ltd.
+8618108235634 Cecilia@youngshechem.com China 2345 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58

View Lastest Price from SUBSTANCE P manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SUBSTANCE P pictures 2022-10-11 SUBSTANCE P
33507-63-0
US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
SUBSTANCE P pictures 2020-02-17 SUBSTANCE P
33507-63-0
US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co
  • SUBSTANCE P pictures
  • SUBSTANCE P
    33507-63-0
  • US $0.00-0.00 / kg
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
  • SUBSTANCE P pictures
  • SUBSTANCE P
    33507-63-0
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co

SUBSTANCE P Spectrum

ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 SUBSTANCE P, F & D VERSION OF S6883*ACET ATE (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE) SUBSTANCE P BOVINE SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11] SUBSTANCE P (TYR8) SUBSTANCE P SUBSTANCE P AMIDE RPKPQFFGLM RPKPQQFFGLM-NH2 substance P (SP) L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-Met-NH2 L-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 Neurokinin P P substance Sub Aids114081 Aids-114081 (S)-N1-((5S,8S,14S,17S,20S)-23-aMino-14,17-dibenzyl-5-carbaMoyl-8-isobutyl-7,10,13,16,19,23-hexaoxo-2-thia-6,9,12,15,18-pentaazatricosan-20-yl)-2-((S)-1-((S)-6-aMino-2-((S)-1-((S)-2-aMino-5-guanidinopentanoyl)pyrrolidine-2-carboxaMido)hexanoyl)pyrrolidine H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate salt Substance P TFA salt Substance P Acetate Substance P,Neurokinin P,Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2,RPKPQQFFGLM-NH2?, >98% TYR8 SUBSTANCE P USP/EP/BP Substance P,Neurokinin P,Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2,RPKPQQFFGLM-NH2 Substance P (9CI, ACI) NK receptor,Neurokinin Receptor,Endogenous Metabolite,Substance P,inhibit,Tachykinin receptor,Inhibitor 33507-63-0free/12769-48-1 P substance amide, Neurokinin P Amide sh-Oligopeptide-73 33507-63-0 C63H98N18O13S C63H98N18O13S1 Tachykinins Peptides Biochemicals and Reagents BioChemical Agonist Amino Acids and Peptides Peptide Tachykinin receptor TPI Peptide Receptors