SUBSTANCE P
- CAS No.
- 33507-63-0
- Chemical Name:
- SUBSTANCE P
- Synonyms
- Sub;TYR8;RPKPQFFGLM;Aids114081;SUBSTANCE P;P substance;Aids-114081;Neurokinin P;RPKPQQFFGLM-NH2;substance P (SP)
- CBNumber:
- CB4114260
- Molecular Formula:
- C63H98N18O13S
- Molecular Weight:
- 1347.63
- MDL Number:
- MFCD00076780
- MOL File:
- 33507-63-0.mol
Melting point | 148 °C |
---|---|
Density | 1.42±0.1 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | H2O: 1 mg/mL |
pka | 13.26±0.46(Predicted) |
form | powder |
color | white |
Water Solubility | Soluble in water, DMSO, and Acetic Acid. |
Sequence | H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
InChIKey | ADNPLDHMAVUMIW-UHFFFAOYSA-N |
FDA UNII | 675VGV5J1D |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H312-H332-H302 |
Precautionary statements | P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501 |
WGK Germany | 3 |
F | 3-10-21 |
SUBSTANCE P price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 05-23-0600 | Substance P - CAS 33507-63-0 - Calbiochem Neuropeptidefoundinhighconcentrationsinthegut. | 33507-63-0 | 1mg | $69 | 2024-03-01 | Buy |
Sigma-Aldrich | 05-23-0600 | Substance P - CAS 33507-63-0 - Calbiochem Neuropeptide found in high concentrations in the gut. | 33507-63-0 | 5MG | $208 | 2024-03-01 | Buy |
Sigma-Aldrich | 05-23-0600 | Substance P - CAS 33507-63-0 - Calbiochem Neuropeptide found in high concentrations in the gut. | 33507-63-0 | 25MG | $560 | 2024-03-01 | Buy |
Alfa Aesar | J63489 | Substance P | 33507-63-0 | 5mg | $172 | 2023-06-20 | Buy |
Alfa Aesar | J63489 | Substance P | 33507-63-0 | 25mg | $675 | 2023-06-20 | Buy |
SUBSTANCE P Chemical Properties,Uses,Production
Uses
Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.
Definition
ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).
General Description
Substance P is a polypeptide consisting of 11 amino acidresidues. It has been implicated in the transmission of“painful” sensory information through the spinal cord tohigher centers in the central nervous system. Substance Pis localized in the primary afferent sensory fibers. Other pharmacologicaleffects are vasodilatation, stimulation of smoothmuscles, stimulation of salivary secretion, and diuresis. In addition,this neuropeptide contributes to some inflammatory responses.Approximately 50% of the known neuropeptides aresynthesized as biologically inactive glycine extended precursorsthat require a carboxy-terminal posttranslational amidationfor biological activity. Amidation enzymes are responsiblefor the conversion of the carboxyl group of the neuropeptide tothe corresponding amide group and include the two amidatingenzymes peptidylglycine α-monooxygenase (PAM) and peptidylamidoglycolatelyase (PGL), which work sequentially toproduce the inflammatory neuropeptide Substance P from aninactive precursor peptide. Much research is being performedto exploit this mechanism of inflammation.
storage
-20°C
SUBSTANCE P Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 14764 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 999 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29831 | 58 |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from SUBSTANCE P manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-10-11 | SUBSTANCE P
33507-63-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
2020-02-17 | SUBSTANCE P
33507-63-0
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
- SUBSTANCE P
33507-63-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
- SUBSTANCE P
33507-63-0
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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