ChemicalBook >> CAS DataBase List >>(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid

(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid

(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid structure

CAS No.: 193146-26-8

Chemical Name:: (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid

Synonyms: Paclitaxel Impurity 72;[3S-(3R*,6S*,7R*,8R*,12Z,15R*,16E)]-3,7-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-15-hydr;(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid;(3S,6R,7S,8S,12Z,15S,16E)-3,7-bis{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic acid;12,16-Heptadecadienoic acid, 3,7-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-4-thiazolyl)-5-oxo-, (3S,6R,7S,8S,12Z,15S,16E)-

CBNumber:: CB41175341

Molecular Formula:: C39H71NO6SSi2

Molecular Weight:: 738.22

MDL Number:

MOL File:: 193146-26-8.mol

Last updated:2023-07-21 08:27:57

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(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid Properties

Boiling point	732.7±60.0 °C(Predicted)
Density	1.016±0.06 g/cm3(Predicted)
solubility	Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene
pka	4.05±0.10(Predicted)
form	Oil

(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B415725	(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoicAcid	193146-26-8	1mg	$880	2021-12-16	Buy
Biosynth Carbosynth	FB18797	(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic acid	193146-26-8	1mg	$1092	2021-12-16	Buy
American Custom Chemicals Corporation	ORS0001285	(3S,6R,7S,12Z,15S,16E)-3,7-BIS-((TERT-BUTYL(DIMETHYL)SILYL)OXY)-15-HYDROXY-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXOHEPTADECA-12,16-DIENOIC ACID 95.00%	193146-26-8	1MG	$1501.5	2021-12-16	Buy
AK Scientific	4556DN	(3S,6R,7S,15S)-3,7-Bis[[tert-butyl(dimethyl)silyl]oxy]-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoicacid	193146-26-8	1mg	$1524	2021-12-16	Buy
American Custom Chemicals Corporation	ORS0001285	(3S,6R,7S,12Z,15S,16E)-3,7-BIS-((TERT-BUTYL(DIMETHYL)SILYL)OXY)-15-HYDROXY-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXOHEPTADECA-12,16-DIENOIC ACID 95.00%	193146-26-8	0.1MG	$243	2021-12-16	Buy

Product number	Packaging	Price	Buy
B415725	1mg	$880	Buy
FB18797	1mg	$1092	Buy
ORS0001285	1MG	$1501.5	Buy
4556DN	1mg	$1524	Buy
ORS0001285	0.1MG	$243	Buy

(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid Chemical Properties,Uses,Production

Chemical Properties

Oil

Uses

An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.

(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid synthesis

Synthesis of (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid from (3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXO-HEPTADECA-12,16-DIENOIC ACID

(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione

(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid Suppliers

Global( 11)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94838	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-83725681-603		China	4505	50
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	55717	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44894	58
Carbosynth	--	sales@carbosynth.com	United Kingdom	6018	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky（shanghai）International Co.,Ltd.	50
S.Z. PhyStandard Bio-Tech. Co., Ltd.	50
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
Energy Chemical	58
Carbosynth	58

193146-26-8((3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid)Related Search:

(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid 7-Xylosyl-10-deacetyltaxol Paclitaxel Impurity 9 N-Desbenzoyl-N-tert-butoxycarbonyl-N,O-isopropylidene-3a€-p-O-benzyl-6,7-dehydro Paclitaxel 2'-O-(Benzyloxycarbonyl) Taxol

(4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid 6-CHLORO-4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE Epothilone B 4-(BENZYLOXYCARBONYLAMINO-METHYL)-BENZOIC ACID 2'-O-tert-Butyl(diMethyl)silyl-7-O-triethylsilyl-2-debenzoyl-4-desacetyl Paclitaxel

(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester BOC-3-ENDO-AMINOBICYCLO[2.2.1]HEPTANE-2-ENDO-CARBOXYLIC ACID (4S,5R)-2,2-DiMethyl-4-[4-(phenylMethoxy)phenyl]-N-DiMethylethoxycarbonyl-3,5-oxazolidinecarboxylic Acid Ethyl Ester 13-{[(3-N-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(triethylsilyl) Baccatin III Docetaxel-D9

Paclitaxel EP Impurity I 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole DHA-paclitaxel

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(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid [3S-(3R*,6S*,7R*,8R*,12Z,15R*,16E)]-3,7-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-15-hydr (3S,6R,7S,8S,12Z,15S,16E)-3,7-bis{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic acid 12,16-Heptadecadienoic acid, 3,7-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-4-thiazolyl)-5-oxo-, (3S,6R,7S,8S,12Z,15S,16E)- Paclitaxel Impurity 72 193146-26-8 Chiral Reagents