ChemicalBook >> CAS DataBase List >>3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one structure

CAS No.: 130049-82-0

Chemical Name:: 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Synonyms: 3-(2-CHLOROETHYL)-9-HYDROXY-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE;3-(2-ChL;Paliperidone-8;Paliperidone Int 1;Paliperidone USP RC C;3-(2-Chloroethyl)-6,7;Paliperidone IMpurity N;Paliperidone Impurity 55;Paliperidone Impurities105;Paliperidone Intermediate 1

CBNumber:: CB41175684

Molecular Formula:: C11H15ClN2O2

Molecular Weight:: 242.7

MDL Number:: MFCD09835552

MOL File:: 130049-82-0.mol

Last updated:2024-01-09 10:39:30

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3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Properties

Melting point	100-102°C
Boiling point	389.3±52.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Methanol (Slightly)
form	Solid
pka	12.97±0.60(Predicted)
color	Pale Orange to Yellow
InChI	InChI=1S/C11H15ClN2O2/c1-7-8(4-5-12)11(16)14-6-2-3-9(15)10(14)13-7/h9,15H,2-6H2,1H3
InChIKey	JKVUGXRJSYRXFN-UHFFFAOYSA-N
SMILES	C12C(O)CCCN1C(=O)C(CCCl)=C(C)N=2
CAS DataBase Reference	130049-82-0(CAS DataBase Reference)
FDA UNII	4M62IXL9X4

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H332-H302
Precautionary statements	P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312
HS Code	2934990002

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C366270	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one	130049-82-0	25mg	$350	2021-12-16	Buy
Biosynth Carbosynth	FC20232	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one	130049-82-0	100mg	$380	2021-12-16	Buy
ChemScene	CS-B0009	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one	130049-82-0	100g	$451	2021-12-16	Buy
Biosynth Carbosynth	FC20232	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one	130049-82-0	25mg	$150	2021-12-16	Buy
AK Scientific	B784	3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one	130049-82-0	5g	$161	2021-12-16	Buy

Product number	Packaging	Price	Buy
C366270	25mg	$350	Buy
FC20232	100mg	$380	Buy
CS-B0009	100g	$451	Buy
FC20232	25mg	$150	Buy
B784	5g	$161	Buy

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Chemical Properties,Uses,Production

Chemical Properties

Pale-Yellow Solid

Uses

Paliperidone USP Related Compound C

Synthesis

A suspension of methanol and 3-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2a]pyrimidin-4-one Hydrochloride in a reactor was heated to 50–55 ℃ to achieve dissolution. Charcoal was then added to the solution, and heating was continued. The contents were filtered, and the charcoal cake was washed with methanol. The combined filtrate, the catalyst (10% Pd/C, 50% wet), and dichloromethane were added to a hydrogenation reactor, and the mixture was hydrogenated. The hydrogen pressure was then reduced to 28–43 psi until the completion of the reaction by HPLC. Then, the catalyst was filtered off and washed with methanol. The combined filtrate was evaporated at a temperature below 50 ℃ under reduced pressure to give a dark grayish oil (crude production 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one).

References

[1] Pavankumar V. Solanki . “Preparation of 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, a Key Intermediate for the Synthesis of Paliperidone.” Organic Preparations and Procedures International 48 3 (2016): Pages 296-302.

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one synthesis

Synthesis of 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one from 3-(2-Chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone)

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Preparation Products And Raw materials

Raw materials

4H-Pyrido[1,2-a]pyrimidin-4-one, 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-(phenylmethoxy)- 3-(2-Chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone) 9-Benxyloxy-3-(2-Chloro ethyl)-2-methyl pyrido[1,2-a]pyrimidine-4-one 3-Ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one Paliperidone Impurity 12

3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride 2-Amino-3-benzyloxypyridine 2-Amino-3-hydroxypyridine 2-Acetylbutyrolactone

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Preparation Products

Paliperidone Palmitate

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Suppliers

Global( 321)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12452	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9353	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Fluoropharm Co., Ltd.	+86-0571-85586753; +8613336034509	sales@fluoropharm.com	China	1290	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58

Supplier	Advantage
LEAPCHEM CO., LTD.	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Fluoropharm Co., Ltd.	60
Shanghai Zheyan Biotech Co., Ltd.	58

View Lastest Price from 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-11-21	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 130049-82-0	US $0.00 / kg	1kg	0.99	20 tons	Hebei Yanxi Chemical Co., Ltd.
2023-09-19	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 130049-82-0	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-09-06	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 130049-82-0	US $30.00-10.00 / KG	50KG	99%	500000kg	Hebei Guanlang Biotechnology Co., Ltd.

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
130049-82-0
US $0.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
130049-82-0
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
130049-82-0
US $30.00-10.00 / KG
99%
Hebei Guanlang Biotechnology Co., Ltd.

130049-82-0(3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one)Related Search:

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3-(2-Chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone) Paliperidone impurity 1 Paliperidone iMpurity I

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3-(2-Chloroethyl)-2-methyl-9-hydroxy-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-α]pyrimidin-4-one 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one ,98% Paliperidone Intermediate 1 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one 9-tetrahydro-9-hydroxy-2-Methyl- 9-Hydroxy-3-(2-chloroethyl)-2-Methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyriMidin-4-one 3-(2-chloroethyl)-9-hydroxy-2-Methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyriMidin-4-one 4H-Pyrido[1,2-a]pyriMidin-4-one,3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl- 3-(2-CHLOROEETHYL)-6,7,8,9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDO (1,2-A) PYRIMIDIN-4-ONE Paliperidone Chloro IMpurity (USP RelatedCoMpound C) Paliperidone USP RC C Paliperidone IMpurity N Paliperidone Related CoMpound C Paliperidone Int 1 Paliperidone Related Compound C (20 mg) (3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-alpha]pyrimidin-4-one) -(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-(2-Chloroethyl)-9-hydroxy-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Paliperidone Related Compound C (3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-alpha]pyrimidin-4-one) 3-(2-Chloroethyl)-6,7 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-p Paliperidone Impurity 9(Paliperidone USP RC C) Paliperidone USP Related Compound C Paliperidone-8 3-(2-chloroethyl)-9-hydroxy-2-methyl- )-6,7,8,9-tetrahydro-9-hydroxy-2-methyL 3-(2-ChL -4H-pyrido[1,2-a]pyrimidine-4-one 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrimidin-4-one 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one ISO 9001：2015 REACH Paliperidone Related Compound C (Paliperidone Chloroethyl Impurity) Paliperidone Impurities105 "3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a] pyrimidine-4-one" 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 130049-82-0 Paliperidone Related Compound C (3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[ (1491831) 3-(2-CHLOROETHYL)-9-HYDROXY-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE Paliperidone Impurity 55 3-(2-Chloroethy)-6,7,8,9- Tetrahydro-2-methyl-4H- pyrido-(1,2-a) pyrimidine-4- one, Hydrochloride 130049-82-0 C11H15O2N2Cl Heterocyclic Compounds Bases & Related Reagents Heterocycles Nucleotides