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Zopolrestat

CAS No.
110703-94-1
Chemical Name:
Zopolrestat
Synonyms
Xedia;Alond;CP-73850;Zopalrestat;Zopolrestatum;Zopolrestat, CP-73850;Zopolrestat >=98% (HPLC);BCSVCWVQNOXFGL-UHFFFAOYSA-N;3-[(5-Trifluoromethyl-2-benzothiazolyl)methyl]-3,4-dihydro-4-oxophthalazine-1-acetic acid;3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic acid
CBNumber:
CB41180112
Molecular Formula:
C19H12F3N3O3S
Molecular Weight:
419.38
MDL Number:
MFCD00865476
MOL File:
110703-94-1.mol
MSDS File:
SDS
Last updated:2023-09-04 15:50:00

Zopolrestat Properties

Melting point 197-198℃
Density 1.58
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
form powder
pka pKa (dioxane/water): 5.46 (1:1); 6.38 (2:1)
color off-white to light brown
FDA UNII 1PV3S9WP3D

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H413
Precautionary statements  P273-P301+P310+P330
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
NFPA 704
0
2 0

Zopolrestat price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Z4527 Zopolrestat ≥98% (HPLC) 110703-94-1 10mg $122 2024-03-01 Buy
Sigma-Aldrich Z4527 Zopolrestat ≥98% (HPLC) 110703-94-1 50mg $475 2024-03-01 Buy
Cayman Chemical 29185 Zopolrestat 110703-94-1 1mg $32 2024-03-01 Buy
Cayman Chemical 29185 Zopolrestat 110703-94-1 5mg $116 2024-03-01 Buy
Cayman Chemical 29185 Zopolrestat 110703-94-1 10mg $214 2024-03-01 Buy
Product number Packaging Price Buy
Z4527 10mg $122 Buy
Z4527 50mg $475 Buy
29185 1mg $32 Buy
29185 5mg $116 Buy
29185 10mg $214 Buy

Zopolrestat Chemical Properties,Uses,Production

Originator

Alond,Pfizer

Uses

Antidiabetic; inhibitor (aldose reductase).

Manufacturing Process

A mixture of 2-methyl-5-trifluoromethylbenzothiazole (1 mole-equivalent), N- bromosuccinimide (1 mole-equivalent), carbon tetrachloride (700 ml) and a catalytic amount of benzoyl peroxide (0.2 g) was refluxed under irradiation by an UV lamp for 14 hours. The reaction mixture was cooled to room temperature, filtered to remove the precipitated succinimide and the filtrate was evaporated to dryness. The resulting solid was chromatographed over silica gel to obtain the 2-bromomethyl-5-trifluoromethyl-benzothiazole. To a mixture of ethyl 4-oxo-3H-phthalazin-1-ylacetate (1 mole-equivalent) and sodium hydride (50% w/w dispersion in mineral oil) in dimethylformamide (150 ml) was added 2-bromomethyl-5-trifluoromethylbenzothiazole (1 mole- equivalent) and the resulting mixture stirred at room temperature for 1 hour. This reaction mixture was poured over ice-water (500 ml); sufficient 10% HCl was added to adjust the pH to about 4.0 and the precipitated crude solid was collected. This was chromatographed over silica gel to obtain the ethyl[4-oxo- 3-(5-trifluoromethylbenzothiazol-2-yl)-3,4-dihydro-phthalazin-1-yl]acetate; MP: 134°-136°C. A solution of methyl or ethyl [4-oxo-3-(5-trifluoromethylbenzothiazol-2-yl)- 3,4-dihydrophthalazin-1-yl]acetate (1 mole-equivalent) in methanol (50 ml)

Therapeutic Function

Aldose reductase inhibitor

Zopolrestat Preparation Products And Raw materials

Zopolrestat Suppliers

Global( 23)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Alfa Chemistry
+1-5166625404 Info@alfa-chemistry.com United States 21317 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123 sj_scrc@sinopharm.com China 9823 79
Shanghai Hekang Biotechnology Co., Ltd. 18939837085 youchemicals@gmail.com China 1813 55
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44894 58
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 61788 58

Zopolrestat Spectrum

3-[(5-Trifluoromethyl-2-benzothiazolyl)methyl]-3,4-dihydro-4-oxophthalazine-1-acetic acid CP-73850 Zopalrestat Zopolrestat, CP-73850 3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic acid Alond Xedia Zopolrestatum Zopolrestat >=98% (HPLC) 1-Phthalazineacetic acid, 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]- BCSVCWVQNOXFGL-UHFFFAOYSA-N diabetic,potent,glyceraldehyde,glucose,aldose,rats,inhibit,Aldose Reductase,Zopolrestat,Inhibitor,oral 2-(4-Oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrophthalazin-1-yl)acetic acid 110703-94-1