Epothilone D
- CAS No.
- 189453-10-9
- Chemical Name:
- Epothilone D
- Synonyms
- Epo D;KOS 862;CS-1161;Ebomycin;NSC 703147;Epothilone D;12,13-Deoxyepo;Desoxyepothilone B;13-Desoxyepothilone B;Epothilone D (KOS-862)
- CBNumber:
- CB41214330
- Molecular Formula:
- C27H41NO5S
- Molecular Weight:
- 491.68
- MDL Number:
- MFCD27976357
- MOL File:
- 189453-10-9.mol
- MSDS File:
- SDS
| Melting point | 63-66°C |
|---|---|
| alpha | D22 -61.3° (c = 2.5 in methanol) |
| Boiling point | 663.7±55.0 °C(Predicted) |
| Density | 1.084±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 13.47±0.70(Predicted) |
| color | white to off-white |
| NCI Dictionary of Cancer Terms | epothilone D; KOS-862 |
| FDA UNII | T0358E0YUF |
| NCI Drug Dictionary | epothilone D |
Epothilone D price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18765 | Epothilone D ≥99% | 189453-10-9 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 18765 | Epothilone D ≥99% | 189453-10-9 | 5mg | $179 | 2024-03-01 | Buy |
| Cayman Chemical | 18765 | Epothilone D ≥99% | 189453-10-9 | 10mg | $317 | 2024-03-01 | Buy |
| Cayman Chemical | 18765 | Epothilone D ≥99% | 189453-10-9 | 25mg | $692 | 2024-03-01 | Buy |
| Usbiological | E3428-75C | Epothilone D | 189453-10-9 | 100ug | $496 | 2021-12-16 | Buy |
Epothilone D Chemical Properties,Uses,Production
Description
Epothilones are microtubule-stabilizing agents with potential anti-neoplastic actions. They are natural macrolides that have high potency in both taxane-sensitive and taxane-resistant models. Epothilone D is a desoxy form of epothilone B (Item No. 10924) that inhibits the growth of a variety of cancer cells both in vitro (IC50 values range from 0.97 to 21 nM) and in mice. Epothilone D is brain penetrant and reduces neurodegeneration in aged tau transgenic mice. Effects include improved axonal transport, decreased tau neuropathology, and reduced hippocampal neuron loss. Epothilone D also rescues microtubule defects and attenuates nigrostriatal degeneration in a mouse model of Parkinson’s disease.
Chemical Properties
White Foam
Uses
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
Uses
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells'' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
Definition
ChEBI: An epithilone that is epithilone C in which the hydrogen at position 13 of the oxacyclohexadec-13-ene-2,6-dione macrocycle has been replaced by a methyl group.
in vitro
epothilone d is a more potent microtubule stabilizer in vitro than epothilone a or b. in vitro, epothilone d showed potent cytotoxicity in a panel of human tumor cell lines, with similar potency to paclitaxel. it also showed definite advantage over paclitaxel in drug-resistant cell lines, and retained its cytotoxicity against a multidrug resistant cell line over-expressing p-glycoprotein [1].
in vivo
in vivo, antitumor efficacy of epothilone d has been observed in both paclitaxel sensitive and resistant xenografts, as well as certain multidrug resistant xenografts including a doxorubinresistant ccrf-cem leukemic cell xenograft [1].
target
Tubulin
IC 50
2.9 nm for mcf-7 cell line; 2.7 nm for kb-31 cell line; 9.5 nm for ccrf-cem cell line
References
[1] konner j, grisham rn, park j, o'connor oa, cropp g, johnson r, hannah al, hensley ml, sabbatini p, mironov s, danishefsky s, hyman d, spriggs dr, dupont j, aghajanian c. phase i clinical, pharmacokinetic, and pharmacodynamic study of kos-862 (epothilone d) in patients with advanced solid tumors and lymphoma. invest new drugs. 2012 dec;30(6):2294-302. doi: 10.1007/s10637-011-9765-7.
Epothilone D Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5601 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
View Lastest Price from Epothilone D manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-03 | Epothilone D USP/EP/BP
189453-10-9
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-05-03 | Epothilone D
189453-10-9
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 800 ton | Shaanxi Dideu Medichem Co. Ltd | |
|
|
2020-05-03 | Epothilone D
189453-10-9
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 800 ton | Shaanxi Dideu Medichem Co. Ltd |
-
- Epothilone D USP/EP/BP
189453-10-9
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Epothilone D
189453-10-9
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Epothilone D
189453-10-9
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
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