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Omeprazole magnesium

CAS No.
95382-33-5
Chemical Name:
Omeprazole magnesium
Synonyms
Prilosec otc;OMeprazole Mg;Unii-426qfe7xlk;Omeprazole magnesium;Omeprazole magnesium CRS;OMeprazole MagnesiuM, EP;Omeprazole magnesium [usan];Omeprazole Magnesium (10 mg);Omeprazole Magnesium (1478549);Omeprazole magnesium,95382-33-5
CBNumber:
CB41230459
Molecular Formula:
C34H36MgN6O6S2
Molecular Weight:
713.12
MDL Number:
MFCD06798050
MOL File:
95382-33-5.mol
MSDS File:
SDS
Last updated:2024-03-16 07:03:48

Omeprazole magnesium Properties

Melting point >170°C (dec.)
storage temp. Inert atmosphere,Room Temperature
solubility Very slightly soluble in water, sparingly soluble in methanol, practically insoluble in heptane.
color White to Off-White
FDA UNII 426QFE7XLK

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
HS Code  2933399090

Omeprazole magnesium price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001043 Omeprazole magnesium European Pharmacopoeia (EP) Reference Standard 95382-33-5 y0001043 $220 2024-03-01 Buy
Sigma-Aldrich 1478549 Omeprazole magnesium 95382-33-5 10mg $394 2024-03-01 Buy
TRC O635065 Omeprazole magnesium 95382-33-5 100mg $305 2021-12-16 Buy
American Custom Chemicals Corporation API0003684 OMEPRAZOLE MAGNESIUM 95.00% 95382-33-5 50MG $224.7 2021-12-16 Buy
Crysdot CD11004379 Omeprazole magnesium 95+% 95382-33-5 25g $40 2021-12-16 Buy
Product number Packaging Price Buy
Y0001043 y0001043 $220 Buy
1478549 10mg $394 Buy
O635065 100mg $305 Buy
API0003684 50MG $224.7 Buy
CD11004379 25g $40 Buy

Omeprazole magnesium Chemical Properties,Uses,Production

Overview

omeprazole magnesium salt is insoluble in water, and it is in crystalline particle form. It has a good stability and can be stored at room temperature for more than 5 years without color change and content decrease. It can be prepared into a tablet. In addition, tablets made of magnesium salts have the characteristics of sustained-release preparations. Omeprazole magnesium which is insoluble in water will go through a slower release and absorption process in the intestinal tract. Modified with magnesium on the omeprazole, the chemical structure is changed to provide patients new drugs with a more secure, better quality, better effect.
Omeprazole magnesium
Figure 1: Omeprazole magnesium

Uses

Omeprazole can inhibit the secretion of gastric acid, clinically used for treatment of heartburn and acid reflux caused by too much gastric acid. In addition, omeprazole magnesium enteric-coated tablets is used for the treatment of duodenal ulcer, gastric ulcer and reflux esophagitis: combined with antibiotics for the treatment of duodenal ulcer with helicobacter pylori infection ; treatment of non-steroidal anti-inflammatory drug-related peptic ulcer and gastroduodenal erosion; used to prevent non-steroidal anti-inflammatory drug-induced peptic ulcer, gastroduodenal erosion or indigestion symptoms; also for the long-term treatment of  chronic relapsing peptic ulcer and reflux esophagitis; symptomatic treatment of heartburn and regurgitation caused by gastro-oesophageal reflux disease; symptomatic treatment of ulcer-like symptoms and acid-related dyspepsia; treatment of Zollinger-Ellison syndrome.

Pharmacokinetics

Absorption: omeprazole is absorbed in the small intestine and is usually completely absorbed within 3-6 hours. The bioavailability is about 60% after repeated administration. The intake of food when administration had no effect on its bioavailability. The plasma protein binding rate of omeprazole is 95%, and the apparent volume of distribution is 0.3L/kg.
Metabolism: omeprazole is mainly completely metabolized in the liver, mainly by the catalytic metabolism of CYP2C19 and CYP3A4 enzyme. The metabolites are sulfone, sulfide and hydroxy omeprazole, and these products have no significant effect on gastric acid secretion. Total plasma clearance rate is 0.3-0.6 L/min. Omeprazole can inhibits the catalytic metabolic effects of CYP2C19 of itself, so that the bioavailability of omeprazole is increased by about 50% over single doses in multi-dose therapy.
Excretion: omeprazole plasma elimination half-life is about 40 minutes (30-90 minutes). Approximately 80% of the metabolites are excreted in the urine and the rest is excreted in the feces.
Factors of patient: omeprazole bioavailability did not change significantly in elderly patients or patients with renal dysfunction; while increased in patients with liver dysfunction, but the clearance rate of these patients were significantly decreased.
Dosage: must swallow the whole piece, at least with a cup of liquid delivery service. The tablet cannot be chewed or crushed; it can be dispersed in water or slightly acidic liquid (such as: fruit juice), the dispersion must be taken within 30 minutes.

Determination of acetic acid residues in raw material

Glacial acetic acid is both reactant and the subject to adjust the pH value in the process of producing omeprazole magnesium. The presence of acidic substances will have an impact on the stability of omeprazole magnesium. The product is easy to degrade in the acidic conditions. In order to increase product stability, a stable and economical method is needed for the strict control of glacial acetic acid residue in the drug substance of omeprazole magnesium. Applying HPLC acetic acid residue control, glacial acetic acid can be completely separated from the components of omeprazole magnesium which can be detected. The accuracy is high, and the detection cost is low.

Determination of sulfate in raw material

Ion chromatography has been applied to the determination of the content of sulfate in omeprazole magnesium sulfate. The method is accurate and reliable for the determination of sulfate in the range of 0.1-40.0μg/mL. It can be used for the determination of sulfate impurity in omeprazole magnesium raw material.

References

[1]http://baike.baidu.com/link?url=2Wq3pYyqcEf4HL3-VGyZaI12nJFX0csqTc0dP1RKUNdiKq_iscQm3FcSW0gYtSx9ghrst5RRZmM3ddMVM66-VHcT4U9GIv32MC6KnFLJN2NLrEHr6NFIbmjdsaHtbgC7XnYaYi-qJmnReX1n1ARm5TXSuKLse_fgqTPoS_ygo9e
[2] Li Juping, Liu Xiaoping, Jin Yongliang. Determination of acetic acid residues in omeprazole magnesium powder by HPLC [J]. Pharmaceutical Research, 2015 (9): 514-516.
[3] Zhao Changjun, Gao Xinzhen. Determination of sulfate in omeprazole magnesium powder by ion chromatography [J] North Pharmaceutical Journal, 2016, 13 (10): 1-2.

Chemical Properties

White or almost white, hygroscopic powder.

Uses

Anti Ulceratives

Uses

Omeprazole Magnesium is an inhibitor of gastric secretion. Used as an anttiulcerative.

brand name

Prilosec (AstraZeneca).

Omeprazole magnesium Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 94)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma Audley
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Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
Hubei Jusheng Technology Co.,Ltd.
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CONIER CHEM AND PHARMA LIMITED
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Longyan Tianhua Biological Technology Co., Ltd
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Career Henan Chemica Co
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AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894 shawn@hirisunpharm.com CHINA 9923 58

View Lastest Price from Omeprazole magnesium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Omeprazole magnesium pictures 2024-03-16 Omeprazole magnesium
95382-33-5
US $35.00-25.00 / kg 1kg 99.8% 200tons/year Sigma Audley
Omeprazole magnesium pictures 2022-12-29 Omeprazole magnesium
95382-33-5
US $1.00 / g 10g 99.5% 1000kg Guangzhou Biocar Biotechnology Co.,Ltd.
Omeprazole magnesium pictures 2020-11-16 Omeprazole magnesium
95382-33-5
US $6.00 / Kg/Bag 25Kg/Bag 99% 20 Tons Longyan Tianhua Biological Technology Co., Ltd
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole magnesium salt (2:1) Omeprazole magnesium Omeprazole magnesium [usan] Prilosec otc Unii-426qfe7xlk OMeprazole MagnesiuM, EP Omeprazole Magnesium (10 mg) OMeprazole Mg Magnesium,bis[6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl-kO]-1H-benzimidazolato-kN3]-, (T-4)- Omeprazole magnesium CRS Omeprazole magnesium,95382-33-5 Omeprazole Magnesium (1478549) Benzene,1-(3-bromopropyl)-5-chloro- 95382-33-5 C34H38MgN6O6S2 C34H36MgN6O6S2