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POLY-L-PROLINE

POLY-L-PROLINE
POLY-L-PROLINE structure
CAS No.
25191-13-3
Chemical Name:
POLY-L-PROLINE
Synonyms
Poly(Pro);polyproline;POLY-L-PROLINE;poly-L-proline mol wt 1000-10000;poly-L-proline mol wt 10000-30000;poly-L-proline mol wt greater than*30000
CBNumber:
CB4125114
Molecular Formula:
C5H9NO2
Formula Weight:
115.13046
MOL File:
25191-13-3.mol

POLY-L-PROLINE Properties

storage temp. 
−20°C

SAFETY

WGK Germany  3

POLY-L-PROLINE price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P2254 Poly-L-proline mol wt 1,000-10,000 25191-13-3 50mg $135 2018-11-20 Buy
Sigma-Aldrich P2254 Poly-L-proline mol wt 1,000-10,000 25191-13-3 1g $1320 2018-11-20 Buy
Sigma-Aldrich P2254 Poly-L-proline mol wt 1,000-10,000 25191-13-3 100mg $226 2018-11-20 Buy
Sigma-Aldrich P3886 Poly-L-proline mol wt >30,000 25191-13-3 500mg $667 2018-11-20 Buy
Sigma-Aldrich P2254 Poly-L-proline mol wt 1,000-10,000 25191-13-3 500mg $853 2018-11-20 Buy

POLY-L-PROLINE Chemical Properties,Uses,Production

Enzyme inhibitor

This indefinite L-proline homopolymer (CAS 25191-13-3) of indefinite length, is frequently used in structural and conformational investigations, adopting one of two major conformations: Poly (L-Pro) I helix (with f and y angles of –83° and 158°, respectively, with peptide bonds that are all cis) and poly (L-Pro) II helix (with f and y angles of –78° and 149°, and containing peptide bonds that are all trans). Collagen strands adopt a conformation similar to that of poly (L-Pro) II helix. Proline-rich regions in other proteins also have secondary structures similar to poly (L-Pro) II. Poly (L-proline) also binds tightly (Ki = 10 μM) to the actin regulatory protein profilin, which within all eukaryotic cells interacts with corresponding Actin-Based Motility-2 sequences (e.g., Xaa-Pro-Pro-Pro- Pro-Pro sequences) found as multiple registers within the actin-filament end-tracking Ena/VASP proteins, WASP, N-WASP, and formins. When microinjected into cells at 10-30 μM final concentrations, poly (L-proline) and analogous GPPPPPGPPPPPGPPPPP sequences in VASP immediately disperse profilin·Actin·ATP from active polymerization sites in lamellipodia and filopodia, thereby arresting all actin-based motility. See also GPPPPPGPPPPPGPPPPP Target (s) : actin-based motility ; procollagen-proline 3-dioxygenase; and procollagen-proline 4- dioxygenase, or prolyl hydroxylase.

POLY-L-PROLINE Preparation Products And Raw materials

Raw materials

Preparation Products


POLY-L-PROLINE Suppliers

Global( 15)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202,021-54308259
+86-21-54291107 info@hanhonggroup.com China 43266 64

25191-13-3(POLY-L-PROLINE)Related Search:


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  • poly-L-proline mol wt greater than*30000
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