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3-Deazauridine

3-Deazauridine structure

CAS No.: 23205-42-7

Chemical Name:: 3-Deazauridine

Synonyms: NSC-126849;3-deazuridine;3-DEAZAURIDINE;3-DEAZAURIDINE CRYSTALLINE;3Deazauridine,3 Deazauridine;3-Deazauridine,anticancer antiviral;1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone;4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone;4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone;4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone

CBNumber:: CB4125871

Molecular Formula:: C10H13NO6

Molecular Weight:: 243.21

MDL Number:: MFCD00006522

MOL File:: 23205-42-7.mol

Last updated:2023-12-20 10:15:24

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3-Deazauridine Properties

Melting point	233-235°C
Boiling point	569.2±50.0 °C(Predicted)
Density	1.718±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
pka	4.50±1.00(Predicted)
color	White to Pale Beige
InChI	InChI=1/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-3,6,8-10,12-13,15-16H,4H2/t6-,8-,9-,10-/s3
InChIKey	CBOKZNLSFMZJJA-FNMQVXAUNA-N
SMILES	[C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=CC(O)=CC1=O \|&1:0,1,3,5,r\|
LogP	-1.693 (est)
FDA UNII	263CU738ZY
NCI Drug Dictionary	3-deazauridine

SAFETY

Risk and Safety Statements

RTECS	UV1148000

3-Deazauridine price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23125	3-Deazauridine ≥98%	23205-42-7	5mg	$32	2024-03-01	Buy
Cayman Chemical	23125	3-Deazauridine ≥98%	23205-42-7	10mg	$61	2024-03-01	Buy
Cayman Chemical	23125	3-Deazauridine ≥98%	23205-42-7	25mg	$139	2024-03-01	Buy
Cayman Chemical	23125	3-Deazauridine ≥98%	23205-42-7	50mg	$243	2024-03-01	Buy
Usbiological	007578	3-Deazauridine	23205-42-7	100mg	$460	2021-12-16	Buy

Product number	Packaging	Price	Buy
23125	5mg	$32	Buy
23125	10mg	$61	Buy
23125	25mg	$139	Buy
23125	50mg	$243	Buy
007578	100mg	$460	Buy

3-Deazauridine Chemical Properties,Uses,Production

Description

3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase, which is considered to be the primary mode of action of this nucleoside analog. This compound has been shown to possess in vitro activity against leukemia L1210 tumor cells, Ehrlich ascites tumor cells, Escherichia coli, and Streptococcus faecium. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with several antitumor agents, including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine. However, only the cytosine arabinoside/3-Deazauridine combination has been explored clinically[1-2].

Uses

Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.

Definition

ChEBI: 3-Deazauridine is a N-glycosyl compound.

References

[1] W J Moriconi, S Taylor, M Slavik. “3-Deazauridine (NSC 126849): an interesting modulator of biochemical response.” Investigational New Drugs 4 1 (1986): 67–84.
[2] W M Shannon, F M Schabel, G Arnett. “3-Deazauridine: inhibition of ribonucleic acid virus-induced cytopathogenic effects in vitro.” Antimicrobial Agents and Chemotherapy 2 3 (1972): 159–63.

3-Deazauridine Preparation Products And Raw materials

Raw materials

Preparation Products

3-Deazauridine Suppliers

Global( 70)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD	0371-55159968 18137130222	haifeng.zhang@pannacean.com	China	387	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	10027	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
ROSEWA HOLDING GROUP CO.,LIMITED	+86-023-62871537	sales@rosewachem.com	China	2830	58
Zhengzhou Granlen Sciences, ltd.	0371-85513397	info@granlen.com	China	1827	58

Supplier	Advantage
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Career Henan Chemica Co	58
BOC Sciences	58
NewCan Biotech Limited	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
ROSEWA HOLDING GROUP CO.,LIMITED	58
Zhengzhou Granlen Sciences, ltd.	58

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4-HYDROXY-1-BETA-D-RIBOFURANOSYL-2[1H]PYRIDONE 3-DEAZAURIDINE 3-deazuridine 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinon 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinone 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridon 3-DEAZAURIDINE CRYSTALLINE 1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone 4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone 4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone 4-Hydroxy-1-(β-D-ribofuranosyl)-1,2-dihydropyridin-2-one 4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone NSC-126849 4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone 1-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-2-HYDROXYPYRIDIN-4-ONE 2(1H)-Pyridinone, 4-hydroxy-1-β-D-ribofuranosyl- 3-Deazauridine, 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, 3-DAU, NSC 126849 2(1H)-Pyridinone,4-hydroxy-1-b-D-ribofuranosyl- 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxypyridin-2(1H)-one 3-Deazauridine,4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, synthetase inhibitor, anticancer drug, NSC126849, 3D2U 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, NSC126849 3Deazauridine,3 Deazauridine 3-Deazauridine,anticancer antiviral 23205-42-7 232005-42-7 20235-47-2 C10H13NO6 Bases & Related Reagents Heterocycles Intermediates & Fine Chemicals Nucleotides Pharmaceuticals