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Triethyl orthoformate

Triethyl orthoformate Structure
Triethyl orthoformate structure
CAS No.
122-51-0
Chemical Name:
Triethyl orthoformate
Synonyms
TRIETHOXYMETHANE;TEOF;ETHYL ORTHOFORMATE;orthoformate;ORTHOFORMIC ACID TRIETHYL ESTER;ETHONE;iethyl orthoforMate;1,1';AETHON;Formylolate
CBNumber:
CB4126252
Molecular Formula:
C7H16O3
Molecular Weight:
148.2
MDL Number:
MFCD00009230
MOL File:
122-51-0.mol
MSDS File:
SDS
Last updated:2023-09-11 17:45:53
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Triethyl orthoformate Properties

Melting point -76 °C (lit.)
Boiling point 146 °C (lit.)
Density 0.891 g/mL at 25 °C (lit.)
vapor density 5.11 (vs air)
vapor pressure 2.9 mm Hg ( 20 °C)
refractive index n20/D 1.391(lit.)
Flash point 86 °F
storage temp. Flammables area
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Liquid
color Clear colorless
Water Solubility 1.35 g/L
Sensitive Moisture Sensitive
Merck 14,6884
BRN 605384
Stability Moisture Sensitive
InChIKey GKASDNZWUGIAMG-UHFFFAOYSA-N
LogP 1.2 at 20℃
CAS DataBase Reference 122-51-0(CAS DataBase Reference)
FDA UNII 355LRR361Q
NIST Chemistry Reference Ethyl orthoformate(122-51-0)
EPA Substance Registry System Ethyl orthoformate (122-51-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS02
Signal word  Warning
Hazard statements  H226
Precautionary statements  P210
Hazard Codes  Xi
Risk Statements  10-36-36/38
Safety Statements  16-26-37/39-36-45-36/39
RIDADR  UN 2524 3/PG 3
WGK Germany  1
RTECS  RM6475000
F  21
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29159080
Toxicity LD50 orally in rats: 7.06 g/kg (Smyth)
NFPA 704
3
0 0

Triethyl orthoformate price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T60453 Triethyl orthoformate reagent grade, 98% 122-51-0 18L $1040 2024-03-01 Buy
Sigma-Aldrich 304050 Triethyl orthoformate anhydrous, 98% 122-51-0 2l $262.2 2024-03-01 Buy
Sigma-Aldrich 304050 Triethyl orthoformate anhydrous, 98% 122-51-0 1l $297 2024-03-01 Buy
TCI Chemical O0066 Triethyl Orthoformate >98.0%(GC) 122-51-0 25mL $16 2024-03-01 Buy
TCI Chemical O0066 Triethyl Orthoformate >98.0%(GC) 122-51-0 500mL $46 2024-03-01 Buy
Product number Packaging Price Buy
T60453 18L $1040 Buy
304050 2l $262.2 Buy
304050 1l $297 Buy
O0066 25mL $16 Buy
O0066 500mL $46 Buy

Triethyl orthoformate Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid; pungent odor. Highly flammable. Slightly soluble in water; soluble in alcohol, ether; decomposes in water.

Uses

A reagent useful for acetylization and imidic ester formation.

Uses

Labelled Prednisolone 21-Sulfate (P703755). Prednisolone 21-Sulfate is a metabolite of Prednisolone (P703740).

Uses

Triethyl orthoformate is used in Bodroux-Chichibabin aldehyde synthesis to prepare an aldehyde with one carbon higher by reacting with Grignard reagent. It is also used in the electrophilic formylation of activated aromatic species such as phenol.

General Description

A clear, colorless liquid with a pungent odor. Less dense than water. Flash point 86°F. Vapors heavier than air. May irritate skin and eyes. Used to make other chemicals.

Reactivity Profile

Triethyl orthoformate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Hazard

Flammable, moderate fire risk.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Flammable

Safety Profile

Moderately toxic by ingestion. Mddly toxic by inhalation, skin contact, and subcutaneous routes. A skin and eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Purification Methods

Fractionate it first at atmospheric pressure, then in a vacuum. If impure, then shake it with aqueous 2% NaOH, dry it with solid KOH and distil it from sodium through a 20cm Vigreux column (p 11). Alternatively, wash it with H2O, dry it over anhydrous K2CO3, filter and fractionate it through a Widmer column (p 11). [Sah & Ma J Am Chem Soc 54 2964 1932, Ohme & Schmitz Justus Liebigs Ann Chem 716 207 1968, Beilstein 2 IV 25.] IRRITANT and FLAMMABLE.

Triethyl orthoformate synthesis

60-29-7
109-94-4
122-51-0
Synthesis of Triethyl orthoformate from Diethyl ether and Ethyl formate

Triethyl orthoformate Preparation Products And Raw materials

Raw materials

Ethanol Sodium Chloroform Sodium ethoxide Sodium ethylate solution,in ethyl alcohol
Benzoyl chloride

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Preparation Products

5-CARBETHOXYURACIL Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE ETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
Chloromethyltriethoxysilane 4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)- 1-CHLORO-4-ISOCYANOBENZENE 3-(1,3,4-OXADIAZOL-2-YL)PYRIDINE 1-CYCLOHEXYLURACIL
METHYL 5-AMINOISOXAZOLE-4-CARBOXYLATE 2,4-DIAMINOPYRIMIDINE-5-CARBOXYLIC ACID 2-AMINO-3,5-DICYANOPYRIDINE Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate 2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE
4-Methylpyrimidine 3-(2-FLUOROBENZYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE 4-Chloro-7-(trifluoromethyl)quinoline 3-Aminopyrazole-4-carboxylic acid
ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 4,5-Dicyanoimidazole ETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE Ethoxylated
1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97% ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 4-AMINO-2-(ETHYLTHIO)-5-(HYDROXYMETHYL)PYRIMIDINE ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE N-FORMYLGLYCINE ETHYL ESTER
1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONE 4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 2-HYDROXY-4-METHYLPYRIMIDINE-5-CARBOXYLIC ACID 4-Acetylphenylboronic acid 2-Formylfuran-5-boronic acid
Diethoxymethyl acetate Estazolam 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID 5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE

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Triethyl orthoformate Suppliers

Global( 513)Suppliers
Supplier Tel Email Country ProdList Advantage
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17367 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671 sales@tnjchem.com China 34572 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12453 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Springchem New Material Technology Co.,Limited 		+86-021-62885108 +8613917661608 info@spring-chem.com China 2068 57
Hangzhou Bayee Chemical Co., Ltd. 		0086-571-86990109 rachelhoo@bayeechem.com China 104 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
Supplier Advantage
Xiamen AmoyChem Co., Ltd
58
SIMAGCHEM CORP
58
Hefei TNJ Chemical Industry Co.,Ltd.
58
Hebei Mojin Biotechnology Co., Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Springchem New Material Technology Co.,Limited 		57
Hangzhou Bayee Chemical Co., Ltd. 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55

Related articles

View Lastest Price from Triethyl orthoformate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Triethyl orthoformate pictures 2024-04-17 Triethyl orthoformate
122-51-0
 US $0.00 / KG 1KG 99.5% 1000mt/year Jinan Finer Chemical Co., Ltd
Triethyl Orthoformate pictures 2024-04-10 Triethyl Orthoformate
122-51-0
 US $0.00 / Kg/Drum 180KG 99.4 1000kg Ningxia Jinhua Chemical Co.,Ltd
Triethyl Orthoformate ( TEOF ) pictures 2024-04-09 Triethyl Orthoformate ( TEOF )
122-51-0
 US $606.00 / T 1T 99% 600T Shandong Luning Pharmaceutical Co., Ltd.

Triethyl orthoformate Spectrum

Triethyl orthoformate(122-51-0)MSTriethyl orthoformate(122-51-0)1HNMRTriethyl orthoformate(122-51-0)13CNMRTriethyl orthoformate(122-51-0)IR1Triethyl orthoformate(122-51-0)Raman

122-51-0(Triethyl orthoformate)Related Search:

Ethyl acetate Benzocaine Ethyl formate Ethanol Triethyl phosphate
2-Ethoxyethanol Ethylparaben Trinexapac-ethyl ISOXADIFEN-ETHYL Urethane
Triethylamine Diethyl azodicarboxylate 2,2,2-Trichloroethyl chloroformate Diethyl phthalate Triisopropyl orthoformate
Trimethoxymethane Trimethyl orthoacetate Trimethyl orthobenzoate

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1,1’,1’’-[methylidynetris(oxy)]tris-Ethane Ethane, 1,1',1''-[methylidynetris(oxy)]tris- Ethane,1,1’,1’’-[methylidynetris(oxy)]tris- Ethyl formate(ortho) 1,1’,1’’-[methylidynetris(oxy)]tris-ethan triethoxy-methan Triethyl ester of Orthoformic acid Triethylester kyseliny orthomravenci triethylesterkyselinyorthomravenci ETHYL-O-FORMATE 1,1,1-TRIETHOXYMETHANE AETHON AKOS BBS-00004276 Triethyl OrthofroMate(TEOF) Ethyl Orthoformate Orthoformic Acid Triethyl Ester Triethoxymethane 1,1' Triethyl orthoforMate, 98%, anhydrous, AcroSeal L-GlutaMine-α-Ketoglutarate(2:1 Triethoxymethane, 1,1',1''-[Methanetriyltris(oxy)]triethane Triethyl orthoformate 98% Triethyl orthoforMate, SuperDry, J&KSeal Triethyl orthoforMate, 98%, SpcDry, Water≤50 ppM (by K.F.), SpcSeal Ethylester kyseliny orthomravenci ethylesterkyselinyorthomravenci Methane, triethoxy- ortho-formic Orthoformic acid ethyl ester orthoformicacid,ethylester Orthomravencan ethylnaty orthomravencanethylnaty Triethoxmethane TRIETHYL-O-FORMATE TRIETHYL ORTHOFORMATE 1-(Diethoxymethoxy)ethane 1,1',1'-(Methylidynetris(oxy))tris(ethane) 1,1’,1’-(methylidynetris(oxy))tris(ethane) TRIETHYL ORTHOFORMATE ANHYDROUS 98% 16457-25GTRIETHYL ORTHOFORMATE TRIETHYL ORTHOFORMATE, ANHYDROUS, 98% TriethylOrthoFormateForSynthesis Troiethylorthoformate TriethylOrthoFormate(Teof) EthylOrthoformate,Certified Orthoformic ester Triethyl orthoformate, 99+% TRIETHYLORTHOFORMATE(ETHONE) ETHYLFORMIAT-ORTHO ortho-Ameisensuretriethylester TRIETHYLORTHOBUTYRATE Triethyl orthoformate, 99+% GC Formic acid anion Formylolate Ethyl orthofromate Triethyl orthofromate Triethyl orthoformate,98% Triethyl orthoformate,1,1,1-Triethoxymethane Triethyl orthoformate, anhydrous, AcroSeal, 98% Triethyl Ortho-ForMiate (TEOF)