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Triethyl orthoformate

Triethyl orthoformate
Triethyl orthoformate structure
CAS No.
122-51-0
Chemical Name:
Triethyl orthoformate
Synonyms
TEOF;ETHONE;AETHON;Formylolate;ortho-formic;ETHYL-O-FORMATE;Triethoxmethane;triethoxy-methan;TRIETHOXYMETHANE;AKOS BBS-00004276
CBNumber:
CB4126252
Molecular Formula:
C7H16O3
Formula Weight:
148.2
MOL File:
122-51-0.mol

Triethyl orthoformate Properties

Melting point:
−76 °C(lit.)
Boiling point:
146 °C(lit.)
Density 
0.891 g/mL at 25 °C(lit.)
vapor density 
5.11 (vs air)
vapor pressure 
2.9 mm Hg ( 20 °C)
refractive index 
n20/D 1.391(lit.)
Flash point:
86 °F
storage temp. 
Flammables area
form 
Liquid
color 
Clear colorless
Water Solubility 
1.35 g/L
Sensitive 
Moisture Sensitive
Merck 
14,6884
BRN 
605384
InChIKey
GKASDNZWUGIAMG-UHFFFAOYSA-N
CAS DataBase Reference
122-51-0(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl orthoformate(122-51-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  Xi
Risk Statements  10-36-36/38
Safety Statements  16-26-37/39-36-45-36/39
RIDADR  UN 2524 3/PG 3
WGK Germany  1
RTECS  RM6475000
21
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29159080
Toxicity LD50 orally in rats: 7.06 g/kg (Smyth)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.

NFPA 704

Diamond Hazard Value Description
3
0 0
Health   0 Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials
Flammability   3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
Special  

(NFPA, 2010)

Triethyl orthoformate price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 304050 Triethyl orthoformate anhydrous, 98% 122-51-0 1l $223 2018-11-13 Buy
Sigma-Aldrich 304050 Triethyl orthoformate anhydrous, 98% 122-51-0 2l $323 2018-11-13 Buy
TCI Chemical O0066 Triethyl Orthoformate >98.0%(GC) 122-51-0 25mL $14 2018-11-22 Buy
TCI Chemical O0066 Triethyl Orthoformate >98.0%(GC) 122-51-0 500mL $28 2018-11-22 Buy
Alfa Aesar A13587 Triethyl orthoformate, 98% 122-51-0 500ml $35.2 2018-11-13 Buy

Triethyl orthoformate Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid; pungent odor. Highly flammable. Slightly soluble in water; soluble in alcohol, ether; decomposes in water.

Uses

Labelled Prednisolone 21-Sulfate (P703755). Prednisolone 21-Sulfate is a metabolite of Prednisolone (P703740).

Uses

A reagent useful for acetylization and imidic ester formation.

General Description

A clear, colorless liquid with a pungent odor. Less dense than water. Flash point 86°F. Vapors heavier than air. May irritate skin and eyes. Used to make other chemicals.

Reactivity Profile

Triethyl orthoformate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Hazard

Flammable, moderate fire risk.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Moderately toxic by ingestion. Mddly toxic by inhalation, skin contact, and subcutaneous routes. A skin and eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Purification Methods

Fractionate it first at atmospheric pressure, then in a vacuum. If impure, then shake it with aqueous 2% NaOH, dry it with solid KOH and distil it from sodium through a 20cm Vigreux column (p 11). Alternatively, wash it with H2O, dry it over anhydrous K2CO3, filter and fractionate it through a Widmer column (p 11). [Sah & Ma J Am Chem Soc 54 2964 1932, Ohme & Schmitz Justus Liebigs Ann Chem 716 207 1968, Beilstein 2 IV 25.] IRRITANT and FLAMMABLE.

Triethyl orthoformate Preparation Products And Raw materials

Raw materials

Preparation Products

5-CARBETHOXYURACIL ETHYL 2-HYDROXY-4-METHYL-5-PYRIMIDINECARBOXYLATE 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE ETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER Chloromethyltriethoxysilane 4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)- 1-CHLORO-4-ISOCYANOBENZENE 3-(1,3,4-OXADIAZOL-2-YL)PYRIDINE 1-CYCLOHEXYLURACIL METHYL 5-AMINOISOXAZOLE-4-CARBOXYLATE 2,4-DIAMINOPYRIMIDINE-5-CARBOXYLIC ACID 2-AMINO-3,5-DICYANOPYRIDINE Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate 2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE 4-Methylpyrimidine 3-(2-FLUOROBENZYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE 4-Chloro-7-(trifluoromethyl)quinoline 3-Aminopyrazole-4-carboxylic acid ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 4,5-Dicyanoimidazole ETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE 1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97% ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 4-AMINO-2-(ETHYLTHIO)-5-(HYDROXYMETHYL)PYRIMIDINE ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE N-FORMYLGLYCINE ETHYL ESTER 1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONE 4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 2-HYDROXY-4-METHYLPYRIMIDINE-5-CARBOXYLIC ACID 4-Acetylphenylboronic acid 2-Formylfuran-5-boronic acid Diethoxymethyl acetate Estazolam 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID 5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE

Triethyl orthoformate Suppliers

Global( 311)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Yancheng Green Chemicals Co.,Ltd
86-515-87883661
86-515-87883652 sales@greenchem-china.com CHINA 349 58
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1730 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Hangzhou Bayee Chemical Co., Ltd.
0086-571-86990109; 0086-18605816692
0086-571-85775919 rachelhoo@bayeechem.com China 98 55
Springchem New Material Technology Co.,Limited
86-21-51752791
86-21-51752789 info@spring-chem.com China 890 57
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
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0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Chemwill Asia Co.,Ltd.
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View Lastest Price from Triethyl orthoformate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-18 Triethyl orthoformate
122-51-0
US $1.00 / kg 1kg 99% Customized career henan chemical co

Triethyl orthoformate Spectrum


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