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Triethyl orthoformate

Triethyl orthoformate
Triethyl orthoformate structure
CAS No.
122-51-0
Chemical Name:
Triethyl orthoformate
Synonyms
1,1';TEOF;ETHONE;AETHON;Formylolate;orthoformate;ortho-formic;ETHYL-O-FORMATE;Triethoxmethane;triethoxy-methan
CBNumber:
CB4126252
Molecular Formula:
C7H16O3
Formula Weight:
148.2
MOL File:
122-51-0.mol

Triethyl orthoformate Properties

Melting point:
-76 °C (lit.)
Boiling point:
146 °C (lit.)
Density 
0.891 g/mL at 25 °C (lit.)
vapor density 
5.11 (vs air)
vapor pressure 
2.9 mm Hg ( 20 °C)
refractive index 
n20/D 1.391(lit.)
Flash point:
86 °F
storage temp. 
Flammables area
form 
Liquid
color 
Clear colorless
Water Solubility 
1.35 g/L
Sensitive 
Moisture Sensitive
Merck 
14,6884
BRN 
605384
InChIKey
GKASDNZWUGIAMG-UHFFFAOYSA-N
CAS DataBase Reference
122-51-0(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl orthoformate(122-51-0)
EPA Substance Registry System
Ethyl orthoformate (122-51-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H226
Precautionary statements  P210-P403+P235-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  10-36-36/38
Safety Statements  16-26-37/39-36-45-36/39
RIDADR  UN 2524 3/PG 3
WGK Germany  1
RTECS  RM6475000
21
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29159080
Toxicity LD50 orally in rats: 7.06 g/kg (Smyth)
NFPA 704
3
0 0

Triethyl orthoformate price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 304050 Triethyl orthoformate anhydrous, 98% 122-51-0 1l $243 2021-12-16 Buy
Sigma-Aldrich 304050 Triethyl orthoformate anhydrous, 98% 122-51-0 2l $352 2021-12-16 Buy
Sigma-Aldrich T60453 Triethyl orthoformate reagent grade, 98% 122-51-0 18 L $880 2021-12-16 Buy
TCI Chemical O0066 Triethyl Orthoformate >98.0%(GC) 122-51-0 25mL $16 2021-12-16 Buy
TCI Chemical O0066 Triethyl Orthoformate >98.0%(GC) 122-51-0 500mL $42 2021-12-16 Buy

Triethyl orthoformate Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid; pungent odor. Highly flammable. Slightly soluble in water; soluble in alcohol, ether; decomposes in water.

Uses

Labelled Prednisolone 21-Sulfate (P703755). Prednisolone 21-Sulfate is a metabolite of Prednisolone (P703740).

Uses

A reagent useful for acetylization and imidic ester formation.

Uses

Triethyl orthoformate is used in Bodroux-Chichibabin aldehyde synthesis to prepare an aldehyde with one carbon higher by reacting with Grignard reagent. It is also used in the electrophilic formylation of activated aromatic species such as phenol.

General Description

A clear, colorless liquid with a pungent odor. Less dense than water. Flash point 86°F. Vapors heavier than air. May irritate skin and eyes. Used to make other chemicals.

Reactivity Profile

Triethyl orthoformate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Hazard

Flammable, moderate fire risk.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Moderately toxic by ingestion. Mddly toxic by inhalation, skin contact, and subcutaneous routes. A skin and eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Purification Methods

Fractionate it first at atmospheric pressure, then in a vacuum. If impure, then shake it with aqueous 2% NaOH, dry it with solid KOH and distil it from sodium through a 20cm Vigreux column (p 11). Alternatively, wash it with H2O, dry it over anhydrous K2CO3, filter and fractionate it through a Widmer column (p 11). [Sah & Ma J Am Chem Soc 54 2964 1932, Ohme & Schmitz Justus Liebigs Ann Chem 716 207 1968, Beilstein 2 IV 25.] IRRITANT and FLAMMABLE.

Triethyl orthoformate Preparation Products And Raw materials

Raw materials

Preparation Products

5-CARBETHOXYURACIL Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE ETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER Chloromethyltriethoxysilane 4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)- 1-CHLORO-4-ISOCYANOBENZENE 3-(1,3,4-OXADIAZOL-2-YL)PYRIDINE 1-CYCLOHEXYLURACIL METHYL 5-AMINOISOXAZOLE-4-CARBOXYLATE 2,4-DIAMINOPYRIMIDINE-5-CARBOXYLIC ACID 2-AMINO-3,5-DICYANOPYRIDINE Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate 2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE 4-Methylpyrimidine 3-(2-FLUOROBENZYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE 4-Chloro-7-(trifluoromethyl)quinoline 3-Aminopyrazole-4-carboxylic acid ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 4,5-Dicyanoimidazole ETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE Ethoxylated 1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97% ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 4-AMINO-2-(ETHYLTHIO)-5-(HYDROXYMETHYL)PYRIMIDINE ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE N-FORMYLGLYCINE ETHYL ESTER 1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONE 4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 2-HYDROXY-4-METHYLPYRIMIDINE-5-CARBOXYLIC ACID 4-Acetylphenylboronic acid 2-Formylfuran-5-boronic acid Diethoxymethyl acetate Estazolam 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID 5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE

Triethyl orthoformate Suppliers

Global( 418)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17384 58
Springchem New Material Technology Co.,Limited
+8613917661608 +86-021-62885108
info@spring-chem.com China 2064 57
Hangzhou Bayee Chemical Co., Ltd.
0086-571-86990109
0086-571-85775919 rachelhoo@bayeechem.com China 105 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9143 55
Tianjin Zhongxin Chemtech Co., Ltd.
+8618622897568 +86-022-66880623
022-66880086 sales@tjzxchem.com China 543 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58

View Lastest Price from Triethyl orthoformate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-23 Triethyl Orthoformate ( TEOF )
122-51-0
US $606.00 / T 1T 99% 600T Shandong Luning Pharmaceutical Co., Ltd.
2022-01-21 Triethyl orthoformate
122-51-0
US $10.00 / KG/Tin 1KG 99% 5000tons per month Wuhan Mulei New Material Technology Co. Ltd
2021-12-01 Triethyl orthoformate
122-51-0
US $5.70 / Kg/Drum 10g 99% 10000kg Hebei Crovell Biotech Co Ltd

Triethyl orthoformate Spectrum


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