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Amlodipine Besylate

Description References
Amlodipine Besylate
Amlodipine Besylate structure
CAS No.
111470-99-6
Chemical Name:
Amlodipine Besylate
Synonyms
Amlor;Vazkor;Amcard;Lowrac;Norvas;NORVASC;Amdepin;Amdipin;Amlodin;Amlopin
CBNumber:
CB4127875
Molecular Formula:
C26H31ClN2O8S
Formula Weight:
567.05094
MOL File:
111470-99-6.mol

Amlodipine Besylate Properties

Melting point:
199-201°C
storage temp. 
Store at RT
solubility 
DMSO: 20 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in DMSO (20 mg/mL), water (10 mM), chloroform, ethanol (14 mg/mL), and methanol.
Merck 
14,491
InChIKey
ZPBWCRDSRKPIDG-UHFFFAOYSA-N
CAS DataBase Reference
111470-99-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36
WGK Germany  3
RTECS  US7967700
HS Code  29333990
Hazardous Substances Data 111470-99-6(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

Amlodipine Besylate price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A5605 Amlodipine besylate ≥98% (HPLC) 111470-99-6 10mg $143 2018-11-13 Buy
Sigma-Aldrich 1029501 Amlodipine besylate United States Pharmacopeia (USP) Reference Standard 111470-99-6 350mg $348 2018-11-13 Buy
TCI Chemical A2353 Amlodipine Besylate >98.0%(HPLC)(N) 111470-99-6 1g $70 2018-11-22 Buy
TCI Chemical A2353 Amlodipine Besylate >98.0%(HPLC)(N) 111470-99-6 5g $234 2018-11-22 Buy
Alfa Aesar J62164 Amlodipine besylate, 98+% 111470-99-6 1g $101 2018-11-13 Buy

Amlodipine Besylate Chemical Properties,Uses,Production

Description

Amlodipine (generic name Amlodipine Besylate) is a class of calcium channel blockers. One of the amlodipine product on the market is Norvasc®.
Amlodipine functionalizes by the dilation of blood vessels and the improvement of blood flow, which lead to lowered blood pressure. Thereby, it is used to treat high bold pressure (hypertension). Lowering high blood pressure also reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions, and kidney problems. Amlodipine is also used to prevent certain types of chest pains (angina), which may help to increase the ability to exercise and decrease the frequency of angina attacks. Amlodipine can be used to treat coronary artery disease (CAD) including chronic stable angina, vasospastic angina, and angiographically documented CAD.

References

[1] http://www.webmd.com/drugs/2/drug-5891/amlodipine-oral/details
[2] https://www.drugs.com/amlodipine.html
[3] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4b30c56-7403-4f69-9a8e-3d82a37e8bc5#section-1

Description

Anilodipine besylate is a new, once-daily, dihydropyridine calcium antagonist useful in the treatment of hypertension and angina.

Chemical Properties

White Crystalline Solid

Originator

Pfizer (USA)

Uses

A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive

Uses

Angiotensin II inhibitor prodrug, antihypertensive

Uses

Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.

Definition

ChEBI: The benzenesulfonate salt of amlodipine.

brand name

Norvasc (Pfizer);Istin.

Biological Activity

L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M).

Amlodipine Besylate Preparation Products And Raw materials

Raw materials

Preparation Products


Amlodipine Besylate Suppliers

Global( 329)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1374 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2548 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1664 55
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 215 58

View Lastest Price from Amlodipine Besylate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Amlodipine Besylate
111470-99-6
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2018-03-14 Amlodipine besilate 111470-99-6
111470-99-6
US $20.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.
2018-05-24 Amlodipine Besylate
111470-99-6
US $1.00 / G 1G 99.5% 1000000 Meihua Biological Technology Co.,Ltd

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