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2-Iodophenol

CAS No.
533-58-4
Chemical Name:
2-Iodophenol
Synonyms
O-IODOPHENOL;ORTHO-IODOPHENOL;DK807;NSC 9245;o-Jodfenol;2-Jodfenol;2-iodo-pheno;2-IODOPHENOL;o-iodo-pheno;2-lodophenol
CBNumber:
CB4130718
Molecular Formula:
C6H5IO
Molecular Weight:
220.01
MDL Number:
MFCD00013963
MOL File:
533-58-4.mol
MSDS File:
SDS
Last updated:2023-12-24 16:54:11

2-Iodophenol Properties

Melting point 37-40 °C (lit.)
Boiling point 186-187 °C/160 mmHg (lit.)
Density 1.947 g/mL at 25 °C (lit.)
Flash point >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Crystalline Powder or Crystalline Low Melting Mass
pka 8.51(at 25℃)
color White or cream to brown
Specific Gravity 1.947
Water Solubility slightly soluble
Sensitive Light Sensitive
Merck 14,5035
BRN 1855300
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey KQDJTBPASNJQFQ-UHFFFAOYSA-N
CAS DataBase Reference 533-58-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII F27L34A8B9
NIST Chemistry Reference Phenol, 2-iodo-(533-58-4)
EPA Substance Registry System Phenol, 2-iodo- (533-58-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  SL5500000
TSCA  T
HazardClass  IRRITANT, LIGHT SENSITIVE
HS Code  29081000
NFPA 704
1
2 0

2-Iodophenol price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 281409 2-Iodophenol 98% 533-58-4 5g $60.4 2024-03-01 Buy
Sigma-Aldrich 281409 2-Iodophenol 98% 533-58-4 25g $121 2024-03-01 Buy
TCI Chemical I0460 2-Iodophenol >99.0%(GC) 533-58-4 5g $41 2024-03-01 Buy
TCI Chemical I0460 2-Iodophenol >99.0%(GC) 533-58-4 25g $134 2024-03-01 Buy
Alfa Aesar A13599 2-Iodophenol, 98% 533-58-4 5g $34.65 2024-03-01 Buy
Product number Packaging Price Buy
281409 5g $60.4 Buy
281409 25g $121 Buy
I0460 5g $41 Buy
I0460 25g $134 Buy
A13599 5g $34.65 Buy

2-Iodophenol Chemical Properties,Uses,Production

Chemical Properties

colorless needle-like crystals or Pale Yellow Low Melting Solid. Slightly soluble in water, easily soluble in organic solvents such as ethanol and ether.

Uses

2-Iodophenol is used in the synthesis of aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity and 3,3-disubstituted-2,3-dihydrobenzofurans. Coupling with phenylacetylene in the presence of a Pd complex and CuI gives 2-phenylbenzofuran in good yield.

Definition

ChEBI: 2-iodophenol is a 2-halophenol and an iodophenol.

Application

2-Iodophenol is a halophenol with antifungal activity. 2-Iodophenol was used in the synthesis of:
aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity
3,3-disubstituted-2,3-dihydrobenzofurans
1,3,5-substituted benzenes.
2-Iodophenol is also used as additive tracers for resist plasm a etching and suzuki reaction.

Preparation

synthesis of 2-iodophenol: phenol (1a) to react with 0.5 equivalent of iodine and 1 equivalent of hydrogen peroxide in water at room temperature for 24 h, 2,6-diiodophenol (2a) and 2-iodophenol (3) were isolated in yields of 21 and 49%, respectively.
synthesis of 2-iodophenol

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 5281, 1988 DOI: 10.1021/jo00257a014

General Description

Rapid palladium-catalyzed carbonylative cyclization reactions of 2-iodophenol with various alkyne under microwave irradiation using Mo(CO)6 as the CO source has been investigated.

Purification Methods

Crystallise 2-iodophenol from CHCl3 or diethyl ether. The acetate has m 65-66o (from MeOH). [Beilstein 6 H 208, 6 II 198, 6 III 774, 6 IV 1074.]

1008106-86-2
533-58-4
Synthesis of 2-Iodophenol from 2-IODOPHENYLBORONIC ACID
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View Lastest Price from 2-Iodophenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
	2-Iodophenol pictures 2023-12-24 2-Iodophenol
533-58-4
US $100.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
2-Iodophenol pictures 2023-04-28 2-Iodophenol
533-58-4
US $0.00-0.00 / KG 1KG 99% 20 mt Hebei Guanlang Biotechnology Co., Ltd.
2-Iodophenol pictures 2023-04-13 2-Iodophenol
533-58-4
US $30.00-10.00 / kg 10kg 99% 100000kg Hebei Guanlang Biotechnology Co,.LTD
  • 	2-Iodophenol pictures
  • 2-Iodophenol
    533-58-4
  • US $100.00-1.00 / KG
  • 99%
  • Henan Fengda Chemical Co., Ltd
  • 2-Iodophenol pictures
  • 2-Iodophenol
    533-58-4
  • US $0.00-0.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.
  • 2-Iodophenol pictures
  • 2-Iodophenol
    533-58-4
  • US $30.00-10.00 / kg
  • 99%
  • Hebei Guanlang Biotechnology Co,.LTD
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