ChemicalBook >> CAS DataBase List >>5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE structure

CAS No.: 256414-75-2

Chemical Name:: 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

Synonyms: SW2871;SEW 2871;BUTTPARK 82\12-95;S1P? Receptor Agonist, SEW2871;SPHINGOSINE-1-PHOSPATE, RECEPTOR S1P1 AGONIST;S1P Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem;5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE;5-[4-Phenyl-5-(trifluoromethyl)thien-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole;1,2,4-Oxadiazole, 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-;5-[4-PHENYL-5-(TRIFLUOROMETHYL)THIOPHEN-2-YL]-3-[3-(TRIFLUOROMETHYL)PHENYL]1,2,4-OXADIAZOLE

CBNumber:: CB4131568

Molecular Formula:: C20H10F6N2OS

Molecular Weight:: 440.36

MDL Number:: MFCD00096600

MOL File:: 256414-75-2.mol

Last updated:2023-06-30 15:45:59

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5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Properties

Melting point	94.5-95.3 °C
Boiling point	490.3±55.0 °C(Predicted)
Density	1.415±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 17 mg/mL
form	solid
pka	-3.48±0.43(Predicted)
color	white
InChIKey	OYMNPJXKQVTQTR-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H300

Precautionary statements

P264-P270-P301+P310-P321-P330-P405-P501

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1/PG 3

WGK Germany

HS Code

2934999090

NFPA 704

	1
2		0

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S3944	SEW2871 ≥98% (HPLC), solid	256414-75-2	1mg	$112.4	2024-03-01	Buy
Cayman Chemical	10006440	SEW2871 ≥98%	256414-75-2	5mg	$32	2024-03-01	Buy
Cayman Chemical	10006440	SEW2871 ≥98%	256414-75-2	10mg	$61	2024-03-01	Buy
Sigma-Aldrich	S3944	SEW2871 ≥98% (HPLC), solid	256414-75-2	5mg	$428	2024-03-01	Buy
Cayman Chemical	10006440	SEW2871 ≥98%	256414-75-2	25mg	$139	2024-03-01	Buy

Product number	Packaging	Price	Buy
S3944	1mg	$112.4	Buy
10006440	5mg	$32	Buy
10006440	10mg	$61	Buy
S3944	5mg	$428	Buy
10006440	25mg	$139	Buy

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Chemical Properties,Uses,Production

Description

Sphingosine-1-phosphate receptor 1 (S1P₁) is one of five high affinity G protein-coupled S1P receptors which mediate a variety of effects including lymphocyte recirculation in the blood. Non-selective S1P receptor agonists, such as FTY720, produce clinical immunosuppression useful for preventing transplant rejection and treating autoimmune diseases. However, they also cause bradycardia by activating S1P₃, the receptor responsible for regulation of heart rate. SEW2871 is a selective S1P₁ receptor agonist in both human and mouse that is not active at the S1P_2-5 receptors. SEW2871, therefore, suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia.

Uses

SEW2871 was used to mimic the effects of sphingosine-1 phosphate in HUVECs to study the innate immunity rendered by long pentraxin 3.

Uses

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE is used as medicament for treating and/or preventing cardiovascular conditions in patients with Fabry disease.

Definition

ChEBI: 5-[4-phenyl-5-(trifluoromethyl)-2-thiophenyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole is an oxadiazole and a ring assembly.

Biological Activity

Novel, potent and selective sphingosine-1-phosphate 1 (S1P 1 ) receptor agonist. Activates S1P 1 receptor with an EC 50 of 13 nM, but does not activate S1P 2 , S1P 3 , S1P 4 or S1P 5 receptors at concentrations up to 10 μ M. Cell-permeable and active in vivo .

Biochem/physiol Actions

SEW2871 is a selective agonist of spingosine-1 phosphate receptor. It exacerbates reperfusion arrhythmias by significantly prolonging the duration of ventricular tachycardia and ventricular fibrillation. SEW2871 modulates inflammatory reactions by influencing lymphocyte homing and cell migration. By the inhibition of proinflammatory molecules, SEW2871 reduces acute renal failure due to ischemia.

storage

Store at RT

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Suppliers

Global( 98)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10828	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
J & K SCIENTIFIC LTD.	76

View Lastest Price from 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-10	5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE 256414-75-2	US $0.01 / KG	1KG	98%; 99%	500g;1kg； 25kg	Career Henan Chemical Co

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE
256414-75-2
US $0.01 / KG
98%; 99%
Career Henan Chemical Co

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Spectrum

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE(256414-75-2)MS

256414-75-2(5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE)Related Search:

Benzotribromide 2,4,6-Trimethylaniline 2-(TRIFLUOROMETHYL)THIOPHENE 5-METHYL-3-PHENYL-1,2,4-OXADIAZOLE 3,5-DIMETHYL-1,2,4-OXADIAZOLE

2,3,5-Trimethylthiophene 3-PHENYLTHIOPHENE 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

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SEW 2871 SPHINGOSINE-1-PHOSPATE, RECEPTOR S1P1 AGONIST SW2871 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE 5-[4-PHENYL-5-(TRIFLUOROMETHYL)THIOPHEN-2-YL]-3-[3-(TRIFLUOROMETHYL)PHENYL]1,2,4-OXADIAZOLE BUTTPARK 82\12-95 SEW-2871, 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole 5-[4-Phenyl-5-(trifluoromethyl)thien-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole S1P? Receptor Agonist, SEW2871 S1P Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem 1,2,4-Oxadiazole, 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 256414-75-2 C20H10F6N2OS Lysophospholipid receptor and related Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds