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marcfortine A

CAS No.
75731-43-0
Chemical Name:
marcfortine A
Synonyms
UK 111866;marcfortine A;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2'(3'H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione, 6',7',8',9',10',10'a-hexahydro-1',1',4,4,12'-pentamethyl-, (2'R,3'aS,9'aS,10'aS)-
CBNumber:
CB41323193
Molecular Formula:
C28H35N3O4
Molecular Weight:
477.602
MDL Number:
MOL File:
75731-43-0.mol
Last updated:2023-05-21 10:59:17

marcfortine A Properties

Melting point 245 °C
Boiling point 660.6±55.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Methanol: soluble
form A solid
pka 12.05±0.60(Predicted)

marcfortine A price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23486 Marcfortine A ≥99% 75731-43-0 1mg $340 2024-03-01 Buy
Cayman Chemical 23486 Marcfortine A ≥99% 75731-43-0 5mg $1523 2024-03-01 Buy
Usbiological M2374-75 Marcfortine A 75731-43-0 1mg $588 2021-12-16 Buy
TRC M197305 MarcfortineA 75731-43-0 2.5mg $625 2021-12-16 Buy
Product number Packaging Price Buy
23486 1mg $340 Buy
23486 5mg $1523 Buy
M2374-75 1mg $588 Buy
M197305 2.5mg $625 Buy

marcfortine A Chemical Properties,Uses,Production

Description

Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.

Uses

Marcfortine A is an indole alkaloid isolated from Aspergillus and Pencillium species.

Uses

Marcfortine A is an indole alkaloid, isolated from Aspergillus and Pencillium species, with potent nematocidal activity. The marcfortines are structurally related to paraherquamides and are thought to act by blocking cholinergic neuromuscular transmission.

marcfortine A Preparation Products And Raw materials

Raw materials

Preparation Products

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marcfortine A UK 111866 Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2'(3'H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione, 6',7',8',9',10',10'a-hexahydro-1',1',4,4,12'-pentamethyl-, (2'R,3'aS,9'aS,10'aS)- 75731-43-0