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ChemicalBook >> CAS DataBase List >>(R)-N-Boc-(3-Pyridyl)alanine

(R)-N-Boc-(3-Pyridyl)alanine

(R)-N-Boc-(3-Pyridyl)alanine Structure
(R)-N-Boc-(3-Pyridyl)alanine structure
CAS No.
98266-33-2
Chemical Name:
(R)-N-Boc-(3-Pyridyl)alanine
Synonyms
BOC-3-(3-PYRIDYL)-D-ALANINE;Boc-DPal;Boc-3-D-Pal-OH;BOC-D-3-PAL-OH;BOC-D-3-PYRIDYLALA;RARECHEM AK ML 0091;BOC-3'-PYRIDYL-D-ALA;BOC-D-ALA(3-PYRI)-OH;BOC-D-3-PYRIDYLALANINE;BOC-D-ALA(3-PYRIDYL)-OH
CBNumber:
CB4133335
Molecular Formula:
C13H18N2O4
Molecular Weight:
266.29
MDL Number:
MFCD00076901
MOL File:
98266-33-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-21 10:31:43
Product description Number Pack Size Price
Boc-D-3-pyridylalanine M781 250mg $10
Boc-3-(3'-pyridyl)-D-alanine ≥ 98% (HPLC) 02685 1G $20
Boc-D-3-pyridylalanine 95% 041433 1g $24
Boc-3-(3'-pyridyl)-D-alanine,98%(HPLC) 98%(HPLC) 02685 5G $72.8
Boc-D-3-pyridylalanine 95% 041433 5g $74
More product size
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(R)-N-Boc-(3-Pyridyl)alanine Properties

Melting point 136.8 °C
Boiling point 409.5°C (rough estimate)
Density 1.1738 (rough estimate)
refractive index 1.6450 (estimate)
storage temp. Inert atmosphere,2-8°C
pka 3.43±0.10(Predicted)
form Solid
color White to off-white
optical activity -16.6551°(C=1.0051g/100ml ETOH)
CAS DataBase Reference 98266-33-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P280-P261-P280g-P302+P352a-P321-P333+P313-P501a
Hazard Codes  Xi
Risk Statements  43
Safety Statements  36/37
WGK Germany  3
HazardClass  IRRITANT
HS Code  29333990
NFPA 704
1
0 0

(R)-N-Boc-(3-Pyridyl)alanine price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific M781 Boc-D-3-pyridylalanine 98266-33-2 250mg $10 2021-12-16 Buy
Chem-Impex 02685 Boc-3-(3'-pyridyl)-D-alanine ≥ 98% (HPLC) 98266-33-2 1G $20 2021-12-16 Buy
Matrix Scientific 041433 Boc-D-3-pyridylalanine 95% 98266-33-2 1g $24 2021-12-16 Buy
Chem-Impex 02685 Boc-3-(3'-pyridyl)-D-alanine,98%(HPLC) 98%(HPLC) 98266-33-2 5G $72.8 2021-12-16 Buy
Matrix Scientific 041433 Boc-D-3-pyridylalanine 95% 98266-33-2 5g $74 2021-12-16 Buy
Product number Packaging Price Buy
M781 250mg $10 Buy
02685 1G $20 Buy
041433 1g $24 Buy
02685 5G $72.8 Buy
041433 5g $74 Buy

(R)-N-Boc-(3-Pyridyl)alanine Chemical Properties,Uses,Production

Chemical Properties

off-white powder

Uses

Boc-D-3-pyridylalanine, is an alanine derivative, used in various chemical synthesis and peptide chemistry.

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

3-(3-Pyridyl)-D-alanine

70702-47-5

(R)-N-Boc-(3-Pyridyl)alanine

98266-33-2

To a suspension of methanol (3.0 mL) containing 3-(3-pyridyl)-D-alanine nickel(II) complex (100.0 mg, 0.130 mmol) was added 1N hydrochloric acid (0.65 mL, 0.648 mmol). The mixture was stirred at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure and the residue was subjected to liquid-liquid separation with dichloromethane (10 mL) and water (10 mL). The aqueous layer was separated and the solvent was removed by evaporation. The resulting solid was dissolved in 8% ammonia (5 mL) and the solution was purified by passing through a cation exchange resin column (SK-1B, 40 mL, eluent: water followed by 4% ammonia) to afford 3-(3-pyridinyl)-D-alanine (17.7 mg, Yield: 81.9%, 97.3% ee) as a white solid.The conditions for HPLC analysis were as follows: column: CROWNPAK CR( +) (5 μm, 150×4.0 mm I.D.); eluent: aqueous perchloric acid (pH 1.0); flow rate: 0.4 mL/min; temperature: 30 ℃; detector: UV 254 nm; retention time (min) and enantiomeric excess ratio as shown in Table 9. The organic layer was washed with 2% ammonia (10 mL, twice), water (10 mL, twice) and saturated brine (10 mL, twice), dried over sodium sulfate and evaporated to remove the solvent to obtain the chiral auxiliary (S-isomer) (63.8 mg, chemical purity: 98.6%, yield: 86.9%). 3-(3-Pyridyl)-D-alanine (16.3 mg, 0.098 mmol) was dissolved in water (1 mL) and acetone (0.5 mL), and acetone (0.25 mL) solution of di-tert-butyl dicarbonate (Boc)2O (34.3 mg, 0.157 mmol) and acetone ( 0.25 mL) solution of triethylamine (15.9 mg, 0.157 mmol) were added. 0.25mL) solution. The mixture was stirred at room temperature for 3.5 hours. After the reaction mixture was concentrated under reduced pressure to a volume ≤ 1 mL, 2-butanol (10 mL) was added. The pH of the aqueous layer was adjusted to 2-3 with 1N hydrochloric acid and the aqueous layer was extracted with 2-butanol (10 mL, 3 times). The organic layer was washed with saturated brine (10 mL, twice), dried over magnesium sulfate and evaporated to remove the solvent to give Boc-3-(3-pyridinyl)-D-alanine (20.5 mg, Yield: 78.5%, Chemical purity: 97.1%) as a colorless solid.

References

[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 10, p. 1846 - 1851
[2] Patent: US2016/102045, 2016, A1. Location in patent: Paragraph 0325-0332
[3] Patent: KR2015/133268, 2015, A. Location in patent: Paragraph 0535; 0537; 0549
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 26, p. 7592 - 7595
[5] Patent: WO2018/167468, 2018, A1. Location in patent: Page/Page column 71

(R)-N-Boc-(3-Pyridyl)alanine Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 3-(3-Pyridyl)-D-alanine Acetone Water Triethylamine

Preparation Products

Antide

(R)-N-Boc-(3-Pyridyl)alanine Suppliers

Global( 192)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
GenicBio Limited 		+86-21-37621270 service@genicbio.com CHINA 991 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29794 58
GL Biochem(Binhai) Ltd. 		+86-021-61263370 +8615301650015 wuqiuyan@glschina.com China 2975 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 18895 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
GenicBio Limited 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
GL Biochem(Binhai) Ltd. 		58
Dideu Industries Group Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Nextpeptide Inc 		58

View Lastest Price from (R)-N-Boc-(3-Pyridyl)alanine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-3-(3-pyridyl)-D-Ala-OH pictures 2026-04-20 Boc-3-(3-pyridyl)-D-Ala-OH
98266-33-2
 US $41.00-30.00 / mg 10g TargetMol Chemicals Inc.
(R)-N-Boc-(3-Pyridyl)alanine pictures 2020-01-05 (R)-N-Boc-(3-Pyridyl)alanine
98266-33-2
 US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co

(R)-N-Boc-(3-Pyridyl)alanine Spectrum

(R)-N-Boc-(3-Pyridyl)alanine(98266-33-2)1HNMR

98266-33-2((R)-N-Boc-(3-Pyridyl)alanine)Related Search:

(R)-N-BOC-(2-PYRIDYL)ALANINE Phenprobamate EC 2.6.1.2 D-Alanine L-Alanine
FMOC-D-3-Fluorophe FMOC-D-3-CYANOPHENYLALANINE Fmoc-3-chloro-D-phenylalanine (R)-N-BOC-3-THIENYLALANINE FMOC-D-3-Trifluoromethylphe
FMOC-D-3-NITROPHENYLALANINE FMOC-D-3-CARBAMOYLPHE FMOC-D-3-METHYLPHENYLALANINE BOC-D-2-NITROPHENYLALANINE BOC-D-2-Fluorophe
DI-TERT-BUTYL ETHER (S)-N-BOC-(2-PYRIDYL)ALANINE (S)-N-BOC-(4-PYRIDYL)ALANINE

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(R)-N-BOC-(3-Pyridyl)alanine, 98% ee (R)-N-BOC-(3-Pyridyl)alanineN-tert-Butoxycarbonyl-3-pyridyl-D-alanine N-Boc-2-(3-pyridyl)-D-alanine, 95% 3-Pyridinepropanoicacid, a-[[(1,1-diMethylethoxy)carbonyl]aMino]-,(aR)- Boc-3-D-Pal-OH BOC-(R)-2-AMINO-3-(3'-PYRIDYL)PROPANOIC ACID BOC-3-(3'-PYRIDYL)-D-ALANINE BOC-3-(3-PYRIDYL)-D-ALA-OH BOC-3'-PYRIDYL-D-ALA BOC-BETA-(3-PYRIDYL)-D-ALANINE BOC-BETA-(3-PYRIDYL)-D-ALA-OH BOC-D-ALA-BETA-(3-PYRIDYL)-OH BOC-D-ALA(3'-PYRIDYL)-OH BOC-D-ALA(3-PYRIDYL)-OH BOC-D-ALA(3-PYRI)-OH BOC-D-3-PAL-OH BOC-D-3-PYRIDYLALA BOC-D-3-PYRIDYLALANINE (R)-N-BOC-(3-PYRIDYL)ALANINE RARECHEM AK ML 0091 (R)-2-TERT-BUTOXYCARBONYLAMINO-3-PYRIDIN-3-YL-PROPIONIC ACID N-TERT-BUTOXYCARBONYL-3-PYRIDYL-D-ALANINE N-ALPHA-T-BOC-BETA-(3-PYRIDYL)-D-ALANINE N-ALPHA-T-BUTOXYCARBONYL-3-(3-PYRIDYL)-D-ALANINE Boc-3-(3'-pyridyl)-D-alanine≥ 98% (HPLC) Boc-D-3-(3-pyridyl)-alanine BOC-(3-PYRIDYL)-D-ALA-OH BOC-D-3-PYRIDYLALANINE 98% N-tert-Butoxycarbonyl-D-3-(3-Pyridyl) Alanine 3-Pyridin-3-yl-D-alanine, N-BOC protected (R)-2-(tert-butoxycarbonylamino)-3-(pyridin-3-yl)propanoic acid N-BOC-(3-PYRIDYL)ALANINE (2R)-2-{[(tert-butoxy)carbonyl]aMino}-3-(pyridin-3-yl)propanoic acid Boc-b-(3-pyridyl)-D-Ala-OH (R)-N-BOC-(3-PYRIDYL)ALANINE, 95%, 98% EE (R)-N-Boc-(3-Pyridyl)alanine USP/EP/BP (Tert-Butoxy)Carbonyl D-3-Pal-OH Boc-DPal (2R)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-3-(3-pyridinyl)propanoate (αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-pyridinepropanoic acid 3-Pyridinepropanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αR)- BOC-3-(3-PYRIDYL)-D-ALANINE N-(tert-butoxycarbonyl)-3-(3-pyridyl)-D-alanine 98266-33-2 Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Alanine Derivatives Phenylalanine analogs and other aromatic alpha amino acids Pyridine series Amino Acid Derivatives Unusual Amino Acids a-amino Amino Acids