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PA 824

PA 824 structure

CAS No.: 187235-37-6

Chemical Name:: PA 824

Synonyms: PRETOMANID;PA 824;CS-930;EOS-60675;Pretomani;(S)-PA 824;PA-824, >=98%;2H4]-Pretomanid;Pretomanid（PA-824）;PA-824(Pretomanid)

CBNumber:: CB41348280

Molecular Formula:: C14H12F3N3O5

Molecular Weight:: 359.26

MDL Number:: MFCD06809939

MOL File:: 187235-37-6.mol

MSDS File:: SDS

Last updated:2024-01-05 13:31:10

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PA 824 Properties

Melting point	149-150℃
Boiling point	462.3±55.0 °C(Predicted)
Density	1.58
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	-0.67±0.40(Predicted)
form	powder
color	white to brown
optical activity	[α]/D -40 to -48°, c = 1 in methanol
FDA UNII	2XOI31YC4N
ATC code	J04AK08

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P280-P304+P340+P312-P305+P351+P338-P337+P313

HS Code

2933992000

NFPA 704

	0
2		0

PA 824 price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1290	PA-824 ≥98% (HPLC)	187235-37-6	10MG	$244	2024-03-01	Buy
Sigma-Aldrich	SML1290	PA-824 ≥98% (HPLC)	187235-37-6	50MG	$587.4	2024-03-01	Buy
TCI Chemical	P2718	PA-824	187235-37-6	25MG	$270	2024-03-01	Buy
TCI Chemical	P2718	PA-824	187235-37-6	100MG	$747	2024-03-01	Buy
Cayman Chemical	13142	PA-824 ≥98%	187235-37-6	1mg	$37	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1290	10MG	$244	Buy
SML1290	50MG	$587.4	Buy
P2718	25MG	$270	Buy
P2718	100MG	$747	Buy
13142	1mg	$37	Buy

PA 824 Chemical Properties,Uses,Production

Uses

A novel anti-tuberculosis drug.

Biological Activity

pa-824, a bicyclic nitroimidazoles, is an anti-tuberculosis (tb) agent that exerts potent in vitro activity against mycobacterium tuberculosis with the minimal inhibition concentration (mic) ranging from 0.015 μg/ml to 0.25 μg/ml and remains actively against a wide range of isolates that are resistant to commonly used anti-tb agents leading to its successful application in the treatment of tb [1].pa-824 has been found to exhibit bactericidal activity against replicating bacilli and non-replicating bacilli under hypoxic or prolonged culture conditions in a dose dependent fashion through two possible mechanisms, which include pa-824 induced inhibition of ketomycolate synthesis and pa-824 mediated donation of nitric oxide during enzymatic nitro-reduction [1].

Biochem/physiol Actions

PA-824 is an anti-tuberculosis drug.

References

[1] ahmad z, peloquin ca, singh rp, derendorf h, tyagi s, ginsberg a, grosset jh, nuermberger el. pa-824 exhibits time-dependent activity in a murine model of tuberculosis. antimicrob agents chemother. 2011 jan;55(1):239-45. doi: 10.1128/aac.00849-10. epub 2010 oct 11.

PA 824 Preparation Products And Raw materials

Raw materials

Preparation Products

PA 824 Suppliers

Global( 181)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Biochempartner	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Shenzhen Excellent Biotech Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
AFINE CHEMICALS LIMITED	58

The Synthesis method and Pharmacokinetics of Pretomanid (PA 824)
Pretomanid (also known as PA 824) is a nitroimidazooxazine antimycobacterial drug with a complex mechanism of action.
Jan 5，2024

View Lastest Price from PA 824 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-12	PA 824 187235-37-6	US $1.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

PA 824
187235-37-6
US $1.00 / KG
99%
Career Henan Chemical Co

PA 824 Spectrum

PA 824(187235-37-6)¹HNMR

187235-37-6(PA 824)Related Search:

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CZC24832 Ribociclib Erlotinib hydrochloride Olaparib

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PA 824 (S)-PA 824 (6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine (S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine 5H-IMidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoroMethoxy)phenyl]Methoxy]-, (6S)- (S)-6-(4-(trifluoromethoxy)benzyloxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine PA-824 PA-824, >=98% (6S)-2-Nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine EOS-60675 2-NITRO-6(S)-[4-(TRIFLUOROMETHOXY)BENZYLOXY]-6,7-DIHYDRO-5H-IMIDAZO[2,1-B][1,3]OXAZINE (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 98+% Pretomanid（PA-824） CS-930 PA-824(Pretomanid) PA-824;PA824;PA 824 PRETOMANID;(S)-PA 824 (S)-PA 824 (Pretomanid) (6S)-2-nitro-6-{[4-(trifluoromethoxy)phenyl]metho xy}-5H,6H,7H-imidazo[2,1-b][1,3]oxazine Pretomanid-D5Q: What is Pretomanid-D5 Q: What is the CAS Number of Pretomanid-D5 PRETOMANID 187235-37-6 PA 824 2H4]-Pretomanid Pretomani 187235-37-6 C14H12F3N3O5 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Inhibitors