Tetraethylammonium Chloride
- CAS No.
- 56-34-8
- Chemical Name:
- Tetraethylammonium Chloride
- Synonyms
- teac;Tetraethylammonium;TEA CHLORIDE;ETAMON CHLORIDE;SKL1479;N2,2,2,2Cl;ammonium chL;Ethamon chloride;Tetraethylammonium choride;tetraethyl-ammoniuchloride
- CBNumber:
- CB4136114
- Molecular Formula:
- C8H20ClN
- Molecular Weight:
- 165.7
- MDL Number:
- MFCD00011828
- MOL File:
- 56-34-8.mol
- MSDS File:
- SDS
| Melting point | 39°C |
|---|---|
| Boiling point | 273.32°C (rough estimate) |
| Density | 1.08 |
| refractive index | 1.5480 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| color | white to light yellow |
| PH | 4.0 to 7.0(50g/L, 25℃) |
| Water Solubility | Soluble in water, ethanol, chloroform, or acetone |
| λmax |
λ: 260 nm Amax: 0.03 λ: 280 nm Amax: 0.03 |
| Sensitive | Hygroscopic |
| Merck | 14,9200 |
| BRN | 3563247 |
| Stability | Stable. Incompatible with strong oxidizing agents. Protect from moisture. |
| InChIKey | YMBCJWGVCUEGHA-UHFFFAOYSA-M |
| CAS DataBase Reference | 56-34-8(CAS DataBase Reference) |
| FDA UNII | 8B82Z83XNN |
| EPA Substance Registry System | Tetraethylammonium chloride (56-34-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BS6125000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29239000 | |||||||||
| Toxicity | LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.) | |||||||||
| NFPA 704 |
|
Tetraethylammonium Chloride price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 113042 | Tetraethylammonium chloride hydrate | 56-34-8 | 25g | $58.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 113042 | Tetraethylammonium chloride hydrate | 56-34-8 | 100g | $187 | 2024-03-01 | Buy |
| TCI Chemical | T0095 | Tetraethylammonium Chloride >98.0%(T) | 56-34-8 | 25g | $47 | 2024-03-01 | Buy |
| TCI Chemical | T0095 | Tetraethylammonium Chloride >98.0%(T) | 56-34-8 | 100g | $107 | 2024-03-01 | Buy |
| Alfa Aesar | J62507 | Tetraethylammonium chloride | 56-34-8 | 25g | $31.5 | 2024-03-01 | Buy |
Tetraethylammonium Chloride Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Tetraethylammonium chloride (TEAC) has been used:
- used for inhibition of peroxynitrite induced relaxation in rat aorta rings
- as a pharmacological blocker of K+ current and Ca2+ induced K+ current in antennal lobe neurons
- for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties
Uses
Medicine (nerve-blocking agent).
Uses
Tetraethylammonium Chloride can be used as a source of tetraethylammonium ions for various pharmaceutical studies and has the ability to block K+ channels in various tissues. Tetraethylammonium Chloride can also block the transmission of nervous impulses across autonomic ganglions.
Definition
ChEBI: A quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen.
General Description
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Biological Activity
Non-selective K + channel blocker.
Biochem/physiol Actions
Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).
in vitro
tetraethylammonium (tea) is a small ion that is thought to block open k channels by binding either to an internal or to an external site. for this reason, it has been used to probe the ion conduction pathway or pore of k channel mutants and a k channel chimera. tea blocks k+ channels at two sites, which define the inner and outer mouths of the channel pores [1].
in vivo
vasorelaxant effect of taurine can be diminished by tea in rat isolated arteries [2]
storage
Room temperature (desiccate)
Purification Methods
Crystallise the chloride from EtOH by adding diethyl ether, from warm water by adding EtOH and diethyl ether, from dimethylacetamide or from CH2Cl2 by addition of diethyl ether. Dry it over P2O5 in vacuum for several days. It also crystallises from acetone/CH2Cl2/hexane (2:2:1) [Blau & Espenson J Am Chem Soc 108 1962 1986, White & Murray J Am Chem Soc 109 2576 1987]. [Beilstein 4 IV 332.]
References
[1] taglialatela m, vandongen am, drewe ja, joho rh, brown am, kirsch ge. patterns of internal and external tetraethylammonium block in four homologous k+ channels. mol pharmacol. 1991 aug;40(2):299-307.
[2] niu lg, zhang ms, liu y, xue wx, liu db, zhang j, liang yq. vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. eur j pharmacol. 2008 feb 2;580(1-2):169-74. epub 2007 oct 25.
[3] shea pa, dunklee pe, et al. preliminary clinical investigation of tetraethylammonium chloride with particular reference to disorders of the circulatory system. calif med. 1948 sep;69(3):193-6.
Tetraethylammonium Chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7377 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Wuhan Boyuan Import & Export Co., LTD | +8615175982296 | Mike@whby-chem.com | China | 974 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2966 | 58 |
View Lastest Price from Tetraethylammonium Chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-16 | Tetraethylammonium Chloride
56-34-8
|
US $5.00-0.50 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-01-08 | Tetraethylammonium chloride
56-34-8
|
US $15.00 / KG | 1KG | 99% | 5000Tons | Wuhan Boyuan Import & Export Co., LTD | |
 |
2023-08-14 | Tetraethylammonium Chloride
56-34-8
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- Tetraethylammonium Chloride
56-34-8
- US $5.00-0.50 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Tetraethylammonium chloride
56-34-8
- US $15.00 / KG
- 99%
- Wuhan Boyuan Import & Export Co., LTD
-
- Tetraethylammonium Chloride
56-34-8
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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