kobusine
- CAS No.
- 27530-78-5
- Chemical Name:
- kobusine
- Synonyms
- kobusine;Hetisan-11β,15β-diol;Hetisan-11,15-diol, (11β,15β)-
- CBNumber:
- CB41376856
- Molecular Formula:
- C20H27NO2
- Molecular Weight:
- 313.43
- MDL Number:
- MFCD01723543
- MOL File:
- 27530-78-5.mol
kobusine Chemical Properties,Uses,Production
Description
Obtained by Suginome and Shimanouti from the precipitation liquors of crude jesaconitine from Aconitum sachalinense, Fr. Schmidt, this alkaloid crystallizes from Me2CO in the rhombic-bisphenoidal system and has (a:b:c = 1.0736: I: 0.9811). It furnishes crystalline salts: the hydrobromide crystallizes as the mono_x0002_hydrate, m.p. 288°C (dec.); [α]22D + 40.68° (H20); hydrochloride (1.5 H20) has m.p. 300°C (dec.);[α]21Dl + 41.4° (H20); perchlorate, m.p. 185-7°C (dec.) although a value of 220°C has also been recorded for this salt; platinichloride, m.p. 262°C (dec.); picrate, m.p. 282-4°C (dec.) and methiodide, m.p. 287°C (dec.). The alkaloid forms a diacetyl derivative, m.p. 139-140°C and catalytic reduction followed by acetylation yields a triacetyltetrahydrokobusine, m.p. 183-4°C (dec.). The alkaloid cannot be hydrolyzed and is non-toxic.
References
Suginome, Shimanouti., Annalen, 545, 220 (1940)
Okamoto., Chern. Pharm. Bull. (Tokyo), 7,44 (1959)
Natsume., ibid, 7,539 (1959)
kobusine Preparation Products And Raw materials
Raw materials
Preparation Products
kobusine Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Supplier | Advantage |
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TargetMol Chemicals Inc. | 58 |