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6-Chloroguanine

6-Chloroguanine structure

CAS No.: 10310-21-1

Chemical Name:: 6-Chloroguanine

Synonyms: 2-AMINO-6-CHLOROPURINE;6-Chloro-7H-purin-2-amine;2-amino-6-chloro-purin;6-CHLORO-2-AMINOPURINE;9H-PURIN-2-AMINE, 6-CHLORO-;2-AMINO-6-CHLOROPURINE (2A6ClP);AURORA KA-689;6-CHLOROGUANINE;TIMTEC-BB SBB003863;2-AMino-6-chlorpurin

CBNumber:: CB4143631

Molecular Formula:: C5H4ClN5

Molecular Weight:: 169.57

MDL Number:: MFCD00075252

MOL File:: 10310-21-1.mol

MSDS File:: SDS

Last updated:2025-09-11 17:37:59

Product description	Number	Pack Size	Price
Famciclovir Related Compound F pharmaceutical secondary standard, certified reference material	PHR2861	50MG	$456
2-Amino-6-chloropurine ≥99%	109789	1g	$26.8
2-Amino-6-chloropurine ≥99%	109789	5g	$42.72
2-Amino-6-chloropurine >98.0%(HPLC)(T)	A1407	1g	$31
2-Amino-6-chloropurine >98.0%(HPLC)(T)	A1407	5g	$91
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6-Chloroguanine Properties

Melting point	>300 °C (lit.)
Boiling point	279.76°C (rough estimate)
Density	1.4937 (rough estimate)
refractive index	1.6110 (estimate)
storage temp.	2-8°C
solubility	Solubility in 1mol/L NaOH
pka	6.65±0.20(Predicted)
form	Powder
color	White to yellow
Water Solubility	1.7 g/L (20 ºC)
BRN	9626
InChI	InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
InChIKey	RYYIULNRIVUMTQ-UHFFFAOYSA-N
SMILES	N1C2C(=NC(N)=NC=2Cl)NC=1
CAS DataBase Reference	10310-21-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	83V03P835E
EPA Substance Registry System	6-Chloro-2-aminopurine (10310-21-1)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P201-P202-P261-P264b-P271-P280i-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362+P364-P403+P233-P501c

Hazard Codes

Xi,Xn

Risk Statements

20/21/22-36/37/38

Safety Statements

22-24/25-36-26

WGK Germany

RTECS

UO7502000

Hazard Note

Irritant/Keep Cold

HazardClass

IRRITANT, KEEP COLD

HS Code

29339900

NFPA 704

	1
2		0

6-Chloroguanine price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2861	Famciclovir Related Compound F pharmaceutical secondary standard, certified reference material	10310-21-1	50MG	$456	2025-07-31	Buy
Sigma-Aldrich	109789	2-Amino-6-chloropurine ≥99%	10310-21-1	1g	$26.8	2025-07-31	Buy
Sigma-Aldrich	109789	2-Amino-6-chloropurine ≥99%	10310-21-1	5g	$42.72	2025-07-31	Buy
TCI Chemical	A1407	2-Amino-6-chloropurine >98.0%(HPLC)(T)	10310-21-1	1g	$31	2025-07-31	Buy
TCI Chemical	A1407	2-Amino-6-chloropurine >98.0%(HPLC)(T)	10310-21-1	5g	$91	2025-07-31	Buy

Product number	Packaging	Price	Buy
PHR2861	50MG	$456	Buy
109789	1g	$26.8	Buy
109789	5g	$42.72	Buy
A1407	1g	$31	Buy
A1407	5g	$91	Buy

6-Chloroguanine Chemical Properties,Uses,Production

Description

6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.

Description

2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-6-chloropurine may be used:

in the enzymatic synthesis of 2′-deoxyguanosine
in the synthesis of 9-alkyl purines
in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases

Uses

2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.

Definition

ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.

General Description

2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.

Synthesis

Preparation of 2-amino-6-chloropurine:
Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield).

References

[1] Heterocycles, 2008, vol. 75, # 11, p. 2803 - 2808
[2] Patent: US5389637, 1995, A
[3] Patent: US4736029, 1988, A
[4] Patent: EP203685, 1991, B1
[5] Patent: US4736029, 1988, A

6-Chloroguanine Preparation Products And Raw materials

Raw materials

Guanine 2,4,5-Triamino-6-chloropyrimidine Formamide, N-(6-chloro-9H-purin-2-yl)- N,N-Dimethylformamide Ammonium hydroxide

Water trichlorophosphate

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Preparation Products

Famciclovir Ganciclovir 6-Thioguanine Penciclovir 6-O-Benzylguanine

2-Amino-6-iodopurine 2-Amino-6-chloropurine Riboside 2-(t-Butyldiphenylsilanyloxy)Ethanol 2-Aminopurine 2-Amino-6-chloro-9H-purine-9-acetic acid benzyl ester

tert-butyl 2-amino-6-chloro-9H-purine-9-carboxylate 6-(pyrrolidin-1-yl)-9H-purin-2-aMine BIIB-021

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6-Chloroguanine Suppliers

Global( 682)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Measure Life Technology Co., LTD	+8613343730176	2924244016@qq.com	China	83	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8770	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12217	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5250	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20171	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
HANGZHOU HAILAN CHEMICAL CO.,LTD.	+86-57156122185 +86-15967590394	sales@hailan-chem.com	China	398	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60

Supplier	Advantage
Hangzhou Measure Life Technology Co., LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Fengda Chemical Co., Ltd	58
airuikechemical co., ltd.	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
HANGZHOU HAILAN CHEMICAL CO.,LTD.	58
Capot Chemical Co.,Ltd.	60

View Lastest Price from 6-Chloroguanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-17	6-Chloroguanine 10310-21-1	US $9.90 / KG	1KG	99	20	HANGZHOU HAILAN CHEMICAL CO.,LTD.
2025-11-17	6-Chloroguanine 10310-21-1	US $0.00 / Kg/Drum	100g/Bag	99%	100mt/year	Jinan Finer Chemical Co., Ltd
2025-11-17	6-Chloroguanine 10310-21-1	US $0.00 / Kg/Drum	1KG	99%min	10 TONS	WUHAN FORTUNA CHEMICAL CO., LTD

6-Chloroguanine
10310-21-1
US $9.90 / KG
99
HANGZHOU HAILAN CHEMICAL CO.,LTD.

6-Chloroguanine
10310-21-1
US $0.00 / Kg/Drum
99%
Jinan Finer Chemical Co., Ltd

6-Chloroguanine
10310-21-1
US $0.00 / Kg/Drum
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

6-Chloroguanine Spectrum

6-Chloroguanine(10310-21-1)MS 6-Chloroguanine(10310-21-1)¹HNMR 6-Chloroguanine(10310-21-1)IR1 6-Chloroguanine(10310-21-1)IR2 6-Chloroguanine(10310-21-1)Raman

10310-21-1(6-Chloroguanine)Related Search:

2-Amino-4-chloro-6-methoxypyrimidine 4,6-Dimethoxy-2-methylthiopyrimidine 2-Amino-4,6-dimethylpyrimidine 6-Chloroguanine 9-(4-Acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine

8-CHLOROGUANINE,CHLOROGUANINE 2-Aminopurine Purine 6-Chloropurine 6-Methoxypurine

2-Amino-6-chloropurine Riboside 2-AMINO-6-CHLORO-9-(BETA-D-2-DEOXYRIBOFURANOSYL)PURINE 2-ACETAMIDO-6-CHLOROPURINE 2-ACETAMIDO-6-CHLORO-9-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE 2-AMINO-6-CHLORO-9-(3,5-DI-O-(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURNANOSYL)PURINE

2-AMINO-6-CHLORO-9H-PURINE-9-ACETIC ACID 9-(4-ACETOXY-3-ACETOXYMETHYLBUTYL)-2-AMINO-6-CHLOROPURINE-D4 2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside

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AURORA KA-689 6-CHLORO-9H-PURIN-2-YLAMINE 6-CHLOROGUANINE 6-Chloro-7H-purin-2-ylamine TIMTEC-BB SBB003863 6-Chloro-2-purinamine 6-Chloro-7H-purine-2-amine 2-Amino-6-chloropuri 6-chloro-9H-purin-2-amine(SALTDATA: FREE) 2-aMino-6-cyanopurine 2-AMino-9H-purine-6-carbonitrile 2-AMino-6-chlorpurin FaMciclovir Related CoMpound F 2-AMino-6-chloropurine, 98+% 2 - aMino - 6 - chlorine purine Famciclovir Related Compound F (25 mg) (2-Amino-6-chloropurine) 1H-Purin-2-amine, 6-chloro- (9CI) 2-Amino-6-chlorpurine Purine, 2-amino-6-chloro- 6-chloro-1h-purin-2-amin 6-chloro-1h-purin-2-amine FAMCICLOVIR INTERMEDIATES 9-(4-acetoxy-3-acetoxymethylbut-1-y)-2-amino-6-chloro purine 2-Amino-6-chloro-9H-purine 6-CHLOROGUANINE CRYSTALLINE 2-Amino-6-Chloropurine(6-Chloroguanine) 1H-Purin-2-amine, 6-chloro- 2-Amino-6-chloro-9H-purine 99% 6-CHLOROGUANINE extrapure 4-Chloro-1,3,5,7-tetraaza-1H-indene-6-amine Clofarabine Impurity 3 2-Amino-6-chloropurine > 2-Amino-6-Chloro-Purin,>98% Famciclovir USP RC F 6-Chloroguanine USP/EP/BP Famciclovir Related Compound F (2-Amino-6-chloropurine) (1269141) 2-amino-6-chloro-purin 2-AMINO-6-CHLOROPURINE 6-CHLORO-2-AMINOPURINE 9H-PURIN-2-AMINE, 6-CHLORO- 6-Chloro-7H-purin-2-amine 2-AMINO-6-CHLOROPURINE (2A6ClP) Famciclovir USP Related Compound F 2-Amino-6-c2-Amino-6-chloropurinehloropurine Famciclovir Related Compound F (2-Amino-6-chloropurine) Entecavir Impurity 43 10310-21-1 10310-21-2 233-686-7 C5H4CIN5 C5H4ClN2 Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Purines Biochemistry Nucleobases and their analogs Nucleosides, Nucleotides & Related Reagents Nucleic acids