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6-Chloroguanine

CAS No.
10310-21-1
Chemical Name:
6-Chloroguanine
Synonyms
2-AMINO-6-CHLOROPURINE;6-Chloro-7H-purin-2-amine;2-amino-6-chloro-purin;6-CHLORO-2-AMINOPURINE;9H-PURIN-2-AMINE, 6-CHLORO-;2-AMINO-6-CHLOROPURINE (2A6ClP);AURORA KA-689;6-CHLOROGUANINE;TIMTEC-BB SBB003863;2-AMino-6-chlorpurin
CBNumber:
CB4143631
Molecular Formula:
C5H4ClN5
Molecular Weight:
169.57
MDL Number:
MFCD00075252
MOL File:
10310-21-1.mol
MSDS File:
SDS
Last updated:2024-03-19 13:53:49

6-Chloroguanine Properties

Melting point >300 °C (lit.)
Boiling point 279.76°C (rough estimate)
Density 1.4937 (rough estimate)
refractive index 1.6110 (estimate)
storage temp. 2-8°C
solubility Solubility in 1mol/L NaOH
form Powder
pka 6.65±0.20(Predicted)
color White to yellow
Water Solubility 1.7 g/L (20 ºC)
BRN 9626
InChI InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
InChIKey RYYIULNRIVUMTQ-UHFFFAOYSA-N
SMILES N1C2C(=NC(N)=NC=2Cl)NC=1
CAS DataBase Reference 10310-21-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 83V03P835E
EPA Substance Registry System 6-Chloro-2-aminopurine (10310-21-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P201-P202-P261-P264b-P271-P280i-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362+P364-P403+P233-P501c
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  UO7502000
10
Hazard Note  Irritant/Keep Cold
HazardClass  IRRITANT, KEEP COLD
HS Code  29339900
NFPA 704
1
2 0

6-Chloroguanine price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2861 Famciclovir Related Compound F pharmaceutical secondary standard, certified reference material 10310-21-1 50MG $485 2024-03-01 Buy
Sigma-Aldrich 109789 2-Amino-6-chloropurine ≥99% 10310-21-1 1g $26 2024-03-01 Buy
Sigma-Aldrich 109789 2-Amino-6-chloropurine ≥99% 10310-21-1 5g $31.2 2024-03-01 Buy
TCI Chemical A1407 2-Amino-6-chloropurine >98.0%(HPLC)(T) 10310-21-1 1g $34 2024-03-01 Buy
TCI Chemical A1407 2-Amino-6-chloropurine >98.0%(HPLC)(T) 10310-21-1 5g $101 2024-03-01 Buy
Product number Packaging Price Buy
PHR2861 50MG $485 Buy
109789 1g $26 Buy
109789 5g $31.2 Buy
A1407 1g $34 Buy
A1407 5g $101 Buy

6-Chloroguanine Chemical Properties,Uses,Production

Description

6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.

Description

2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-6-chloropurine may be used:

  • in the enzymatic synthesis of 2′-deoxyguanosine
  • in the synthesis of 9-alkyl purines
  • in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases

Uses

2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.

Definition

ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.

General Description

2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.

Synthesis

Preparation of 2-amino-6-chloropurine:
Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield).

Global( 649)Suppliers
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Hangzhou Measure Life Technology Co., LTD
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ATK CHEMICAL COMPANY LIMITED
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View Lastest Price from 6-Chloroguanine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Chloroguanine pictures 2024-06-25 6-Chloroguanine
10310-21-1
US $0.00 / Kg/Drum 100g/Bag 99% 100mt/year Jinan Finer Chemical Co., Ltd
2-Amino-6-chloropurine pictures 2024-03-19 2-Amino-6-chloropurine
10310-21-1
US $0.00-0.00 / g 1g 99.99% 20 tons airuikechemical co., ltd.
6-Chloroguanine pictures 2024-02-06 6-Chloroguanine
10310-21-1
US $0.00-0.00 / kg 1kg 98% 500kg per month Yunbio Tech Co.,Ltd.
  • 6-Chloroguanine pictures
  • 6-Chloroguanine
    10310-21-1
  • US $0.00 / Kg/Drum
  • 99%
  • Jinan Finer Chemical Co., Ltd
AURORA KA-689 6-CHLORO-9H-PURIN-2-YLAMINE 6-CHLOROGUANINE 6-Chloro-7H-purin-2-ylamine TIMTEC-BB SBB003863 6-Chloro-2-purinamine 6-Chloro-7H-purine-2-amine 2-Amino-6-chloropuri 6-chloro-9H-purin-2-amine(SALTDATA: FREE) 2-aMino-6-cyanopurine 2-AMino-9H-purine-6-carbonitrile 2-AMino-6-chlorpurin FaMciclovir Related CoMpound F 2-AMino-6-chloropurine, 98+% 2 - aMino - 6 - chlorine purine Famciclovir Related Compound F (25 mg) (2-Amino-6-chloropurine) 1H-Purin-2-amine, 6-chloro- (9CI) 2-Amino-6-chlorpurine Purine, 2-amino-6-chloro- 6-chloro-1h-purin-2-amin 6-chloro-1h-purin-2-amine FAMCICLOVIR INTERMEDIATES 9-(4-acetoxy-3-acetoxymethylbut-1-y)-2-amino-6-chloro purine 2-Amino-6-chloro-9H-purine 6-CHLOROGUANINE CRYSTALLINE 2-Amino-6-Chloropurine(6-Chloroguanine) 1H-Purin-2-amine, 6-chloro- 2-Amino-6-chloro-9H-purine 99% 6-CHLOROGUANINE extrapure 4-Chloro-1,3,5,7-tetraaza-1H-indene-6-amine Clofarabine Impurity 3 2-Amino-6-chloropurine > 2-Amino-6-Chloro-Purin,>98% Famciclovir USP RC F 6-Chloroguanine USP/EP/BP Famciclovir Related Compound F (2-Amino-6-chloropurine) (1269141) 2-amino-6-chloro-purin 2-AMINO-6-CHLOROPURINE 6-CHLORO-2-AMINOPURINE 9H-PURIN-2-AMINE, 6-CHLORO- 6-Chloro-7H-purin-2-amine 2-AMINO-6-CHLOROPURINE (2A6ClP) Famciclovir USP Related Compound F 2-Amino-6-c2-Amino-6-chloropurinehloropurine Famciclovir Related Compound F (2-Amino-6-chloropurine) 10310-21-1 10310-21-2 233-686-7 C5H4CIN5 C5H4ClN2 Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Purines Biochemistry Nucleobases and their analogs Nucleosides, Nucleotides & Related Reagents Nucleic acids Bases & Related Reagents