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6-Chloroguanine

6-Chloroguanine structure

CAS No.: 10310-21-1

Chemical Name:: 6-Chloroguanine

Synonyms: 2-AMINO-6-CHLOROPURINE;6-Chloro-7H-purin-2-amine;2-amino-6-chloro-purin;6-CHLORO-2-AMINOPURINE;9H-PURIN-2-AMINE, 6-CHLORO-;2-AMINO-6-CHLOROPURINE (2A6ClP);AURORA KA-689;6-CHLOROGUANINE;TIMTEC-BB SBB003863;2-AMino-6-chlorpurin

CBNumber:: CB4143631

Molecular Formula:: C5H4ClN5

Molecular Weight:: 169.57

MDL Number:: MFCD00075252

MOL File:: 10310-21-1.mol

MSDS File:: SDS

Last updated:2023-08-01 14:32:22

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6-Chloroguanine Properties

Melting point	>300 °C (lit.)
Boiling point	279.76°C (rough estimate)
Density	1.4937 (rough estimate)
refractive index	1.6110 (estimate)
storage temp.	2-8°C
solubility	Solubility in 1mol/L NaOH
form	Powder
pka	6.65±0.20(Predicted)
color	White to yellow
Water Solubility	1.7 g/L (20 ºC)
BRN	9626
InChI	InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
InChIKey	RYYIULNRIVUMTQ-UHFFFAOYSA-N
SMILES	N1C2C(=NC(N)=NC=2Cl)NC=1
CAS DataBase Reference	10310-21-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	83V03P835E
EPA Substance Registry System	6-Chloro-2-aminopurine (10310-21-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P201-P202-P261-P264b-P271-P280i-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362+P364-P403+P233-P501c

Hazard Codes

Xi,Xn

Risk Statements

20/21/22-36/37/38

Safety Statements

22-24/25-36-26

WGK Germany

RTECS

UO7502000

Hazard Note

Irritant/Keep Cold

HazardClass

IRRITANT, KEEP COLD

HS Code

29339900

NFPA 704

	1
2		0

6-Chloroguanine price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	109789	2-Amino-6-chloropurine ≥99%	10310-21-1	1g	$25	2023-06-20	Buy
Sigma-Aldrich	109789	2-Amino-6-chloropurine ≥99%	10310-21-1	5g	$50	2023-06-20	Buy
Sigma-Aldrich	PHR2861	Famciclovir Related Compound F pharmaceutical secondary standard, certified reference material	10310-21-1	50MG	$424	2022-05-15	Buy
TCI Chemical	A1407	2-Amino-6-chloropurine >98.0%(HPLC)(T)	10310-21-1	1g	$34	2023-06-20	Buy
TCI Chemical	A1407	2-Amino-6-chloropurine >98.0%(HPLC)(T)	10310-21-1	5g	$101	2023-06-20	Buy

Product number	Packaging	Price	Buy
109789	1g	$25	Buy
109789	5g	$50	Buy
PHR2861	50MG	$424	Buy
A1407	1g	$34	Buy
A1407	5g	$101	Buy

6-Chloroguanine Chemical Properties,Uses,Production

Description

6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.

Description

2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-6-chloropurine may be used:

in the enzymatic synthesis of 2′-deoxyguanosine
in the synthesis of 9-alkyl purines
in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases

Uses

2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.

Definition

ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.

General Description

2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.

Synthesis

Preparation of 2-amino-6-chloropurine:
Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield).

6-Chloroguanine Preparation Products And Raw materials

Raw materials

Guanine 2,4,5-Triamino-6-chloropyrimidine

Preparation Products

Famciclovir Ganciclovir 6-Thioguanine Penciclovir 6-O-Benzylguanine

2-Amino-6-iodopurine 2-Amino-6-chloropurine-9-riboside 2-(t-Butyldiphenylsilanyloxy)Ethanol 2-Aminopurine 2-Amino-6-chloro-9H-purine-9-acetic acid benzyl ester

tert-butyl 2-amino-6-chloro-9H-purine-9-carboxylate 6-(pyrrolidin-1-yl)-9H-purin-2-aMine BIIB-021

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6-Chloroguanine Suppliers

Global( 622)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Measure Life Technology Co., LTD	+8613343730176	2924244016@qq.com	China	83	58
Hebei Mojin Biotechnology Co., Ltd	15028179902 +8615028179902	sales@hbmojin.com	China	10844	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2513	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29811	60
Henan DaKen Chemical CO.,LTD.	+86-371-66670886	info@dakenchem.com	China	18731	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21975	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32047	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29922	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6118	58

Supplier	Advantage
Hangzhou Measure Life Technology Co., LTD	58
Hebei Mojin Biotechnology Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Capot Chemical Co.,Ltd.	60
Henan DaKen Chemical CO.,LTD.	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58

View Lastest Price from 6-Chloroguanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-09-25	6-Chloroguanine 10310-21-1	US $0.00 / Kg/Drum	100g/Bag	99%	100mt/year	Jinan Finer Chemical Co., Ltd
2023-08-07	6-Chloroguanine 10310-21-1	US $0.00-0.00 / kg	1kg	98%	500kg per month	Yunbio Tech Co.,Ltd.
2023-08-02	6-Chloroguanine 10310-21-1	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

6-Chloroguanine
10310-21-1
US $0.00 / Kg/Drum
99%
Jinan Finer Chemical Co., Ltd

6-Chloroguanine
10310-21-1
US $0.00-0.00 / kg
98%
Yunbio Tech Co.,Ltd.

6-Chloroguanine
10310-21-1
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

6-Chloroguanine Spectrum

6-Chloroguanine(10310-21-1)MS 6-Chloroguanine(10310-21-1)IR1 6-Chloroguanine(10310-21-1)IR2 6-Chloroguanine(10310-21-1)Raman

10310-21-1(6-Chloroguanine)Related Search:

2-AMINO-6-CHLOROPURINE-2'-DEOXYRIBOSIDE-5'-TRIPHOSPHATE LITHIUM SALT 2-AMINO-6-CHLORO-9-(BETA-D-2-DEOXYRIBOFURANOSYL)PURINE 6-CHLOROGUANINE RIBOSIDE,6-Chloroguanine nucleoside,(-)-2-Amino-6-chloropurine riboside, 6-Chloroguanine riboside [2-(2-AMINO-6-CHLORO-PURIN-9-YL)-ETHOXYMETHYL]-PHOSPHONIC ACID BIS-(2,2,2-TRIFLUORO-ETHYL) ESTER 2-AMINO-6-CHLOROPURINERIBOSIDE-5'-TRIPHOSPHATE LITHIUM SALT

9-(4-ACETOXYMETHYLBUT-1-YL)-2-AMINO-6-CHLOROPURINE AURORA KA-73 2-AMINO-6-CHLORO-9H-PURINE-9-ACETIC ACID AURORA KA-61 2-AMINO-6-CHLORO-7-ISOPROPYLPURINE

TIMTEC-BB SBB002967 2-AMINO-6-CHLORO-9-(3,5-DI-O-(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURNANOSYL)PURINE 2-ACETAMIDO-6-CHLORO-9-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE 9-(4-Acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine 9-(4-ACETOXY-3-ACETOXYMETHYLBUTYL)-2-AMINO-6-CHLOROPURINE-D4

2-ACETAMIDO-9-(2,3,5-TRI-O-BENZYL-BETA-D-ARABINOFURANOSYL)-6-CHLORO-9H-PURINE 2-Amino-6-chloroguanine AURORA KA-37

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AURORA KA-689 6-CHLORO-9H-PURIN-2-YLAMINE 6-CHLOROGUANINE 6-Chloro-7H-purin-2-ylamine TIMTEC-BB SBB003863 6-Chloro-2-purinamine 6-Chloro-7H-purine-2-amine 2-Amino-6-chloropuri 6-chloro-9H-purin-2-amine(SALTDATA: FREE) 2-aMino-6-cyanopurine 2-AMino-9H-purine-6-carbonitrile 2-AMino-6-chlorpurin FaMciclovir Related CoMpound F 2-AMino-6-chloropurine, 98+% 2 - aMino - 6 - chlorine purine Famciclovir Related Compound F (25 mg) (2-Amino-6-chloropurine) 1H-Purin-2-amine, 6-chloro- (9CI) 2-Amino-6-chlorpurine Purine, 2-amino-6-chloro- 6-chloro-1h-purin-2-amin 6-chloro-1h-purin-2-amine FAMCICLOVIR INTERMEDIATES 9-(4-acetoxy-3-acetoxymethylbut-1-y)-2-amino-6-chloro purine 2-Amino-6-chloro-9H-purine 6-CHLOROGUANINE CRYSTALLINE 2-Amino-6-Chloropurine(6-Chloroguanine) 1H-Purin-2-amine, 6-chloro- 2-Amino-6-chloro-9H-purine 99% 6-CHLOROGUANINE extrapure 4-Chloro-1,3,5,7-tetraaza-1H-indene-6-amine Clofarabine Impurity 3 2-Amino-6-chloropurine > 2-Amino-6-Chloro-Purin,>98% Famciclovir USP RC F 6-Chloroguanine USP/EP/BP Famciclovir Related Compound F (2-Amino-6-chloropurine) (1269141) 2-amino-6-chloro-purin 2-AMINO-6-CHLOROPURINE 6-CHLORO-2-AMINOPURINE 9H-PURIN-2-AMINE, 6-CHLORO- 6-Chloro-7H-purin-2-amine 2-AMINO-6-CHLOROPURINE (2A6ClP) Famciclovir USP Related Compound F 2-Amino-6-c2-Amino-6-chloropurinehloropurine Famciclovir Related Compound F (2-Amino-6-chloropurine) 10310-21-1 10310-21-2 233-686-7 C5H4CIN5 C5H4ClN2 Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Purines Biochemistry Nucleobases and their analogs Nucleosides, Nucleotides & Related Reagents Nucleic acids Bases & Related Reagents