1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate
![1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Structure](CAS/GIF/241127-58-2.gif)
- CAS No.
- 241127-58-2
- Chemical Name:
- 1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate
- Synonyms
- Adaphostin;1-Adamantyl 4-((2;5-Dihydroxybenzyl)Amino)Benzoate;1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate;1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate;4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoicacidtricyclo[3.3.1.13,7]dec-1-ylester;Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-yl ester;Apoptosis,tyrosine kinase,inhibit,Bcr-Abl,Adaphostin,chronic myelogenous leukemia,myeloid,Inhibitor,ROS,NSC-680410,p210Bcr/abl,NSC680410,CML
- CBNumber:
- CB41456086
- Molecular Formula:
- C24H27NO4
- Molecular Weight:
- 393.48
- MDL Number:
- MFCD06411386
- MOL File:
- 241127-58-2.mol
Last updated:2023-09-04 15:51:00
1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1110 | Adaphostin ≥98% (HPLC) | 241127-58-2 | 5mg | $92.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1110 | Adaphostin ≥98% (HPLC) | 241127-58-2 | 25mg | $317 | 2022-05-15 | Buy |
| TRC | A225020 | Adaphostin | 241127-58-2 | 250mg | $1320 | 2021-12-16 | Buy |
| Usbiological | 254543 | Adaphostin | 241127-58-2 | 10mg | $403 | 2021-12-16 | Buy |
| Usbiological | 001651 | Adaphostin | 241127-58-2 | 25mg | $460 | 2021-12-16 | Buy |
1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Chemical Properties,Uses,Production
Uses
Novel antitumor agent that induces apoptosis in tumor cells through inhibition of the tyrosine kinase BCR/ABL.
Biological Activity
p210 bcr/abl tyrosine kinase inhibitor (IC 50 = 14 μ M). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC 50 values range from 16.8 to 216.3 nM) in vitro . Displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro .
Synthesis of 1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-
1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Preparation Products And Raw materials
Raw materials
Preparation Products
1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Suppliers
Global( 38)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate
4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoicacidtricyclo[3.3.1.13,7]dec-1-ylester
Adaphostin
5-Dihydroxybenzyl)Amino)Benzoate
1-Adamantyl 4-((2
Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-yl ester
1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate
Apoptosis,tyrosine kinase,inhibit,Bcr-Abl,Adaphostin,chronic myelogenous leukemia,myeloid,Inhibitor,ROS,NSC-680410,p210Bcr/abl,NSC680410,CML
241127-58-2
Amines
Aromatics
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals