ChemicalBook >> CAS DataBase List >>2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)

2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)

CAS No.
235106-62-4
Chemical Name:
2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)
Synonyms
MDT637;MDT-637;VP 14637;2,2'-[(4-Hydroxyphenyl)Methylene]bis[4-[[(5-Methyl-1H-tetrazol-1-yl)iMino]Methyl]phenol;Phenol, 2,2'-[(4-hydroxyphenyl)methylene]bis[4-[[(5-methyl-1H-tetrazol-1-yl)imino]methyl]-;2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL);(E)-2,2'-((4-Hydroxyphenyl)methylene)bis(4-((E)-(5-methyl-1H-tetrazol-1-ylimino)methyl)phenol)
CBNumber:
CB41477009
Molecular Formula:
C25H22N10O3
Molecular Weight:
510.51
MDL Number:
MFCD26097272
MOL File:
235106-62-4.mol
Last updated:2023-05-18 11:31:04

2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Properties

Melting point >225°C (dec.)
Boiling point 816.7±75.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
storage temp. Amber Vial, Refrigerator
solubility Aqueous Base (Slightly), DMSO (Slightly)
form Solid
pka 7.67±0.50(Predicted)
color White to Pale Beige
Stability Light Sensitive
FDA UNII HCW4G0O030

2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17805 VP-14637 ≥98% 235106-62-4 1mg $62 2024-03-01 Buy
Cayman Chemical 17805 VP-14637 ≥98% 235106-62-4 5mg $211 2024-03-01 Buy
Cayman Chemical 17805 VP-14637 ≥98% 235106-62-4 10mg $357 2024-03-01 Buy
Usbiological 022868 VP 14637 235106-62-4 10mg $460 2021-12-16 Buy
TRC V785000 VP14637 235106-62-4 10mg $185 2021-12-16 Buy
Product number Packaging Price Buy
17805 1mg $62 Buy
17805 5mg $211 Buy
17805 10mg $357 Buy
022868 10mg $460 Buy
V785000 10mg $185 Buy

2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Chemical Properties,Uses,Production

Uses

Human respiratory syncytial virus (HRSV) is a major respiratory viral pathogen causing moderate to severe upper and lower respiratory tract infections in all ages and across a wide range of patient populations. VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms by binding into a small hydrophobic cavity in the inner core of F protein, interacting simultaneously with both the HR1 and HR2 domains.

Uses

Human respiratory syncytial virus (HRSV) is a major respiratory viral pathogen causing moderate to severe upper and lower respiratory tract infections in all ages and across a wide range of patient po pulations. usly with both the HR1 and HR2 domains

Biological Activity

ec50: 5.4 nm for rsv fusionvp-14637 is an inhibitor of rsv.respiratory syncytial virus (rsv) is the leading cause of respiratory tract infections in humans. rsv f protein that mediates fusion of the viral envelope with the host cell membrane has become a target of anti-rsv treatment.

in vitro

previous study demonstrated that vp-14637 did not block rsv adsorption but inhibited rsv-induced cell-cell fusion and specifically bound to rsv-infected cells. vp-14637 was capable of specifically interacting with the rsv fusion protein. rsv variants resistant to vp-14637 were selected, in which no mutations arose in hr1, indicating a mechanism other than direct disruption of the heptad repeat interaction. the f proteins containing the resistance mutations exhibited greatly reduced binding of vp-14637 [1].

in vivo

in cotton rats, animals given as little as 126 microg/kg of vp-14637 by small droplet aerosol starting 1 day after experimental virus infection with either a rsv a or b subtype consistently had significantly lower mean pulmonary rsv titers and reduced histopathological findings than mock-treated animals or cotton rats given placebo. in addition, no cotton rat treated with vp14637 had any evident untoward responses [2].

References

[1] douglas, j. l.,panis, m.l.,ho, e., et al. inhibition of respiratory syncytial virus fusion by the small molecule vp-14637 via specific interactions with f protein. journal of virology 77(9), 5054-5064 (2003).
[2] wyde pr, laquerre s, chetty sn, gilbert be, nitz tj, pevear dc. antiviral efficacy of vp14637 against respiratory syncytial virus in vitro and in cotton rats following delivery by small droplet aerosol. antiviral res. 2005 oct;68(1):18-26.

2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Preparation Products And Raw materials

Raw materials

Preparation Products

2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Suppliers

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2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) VP 14637 2,2'-[(4-Hydroxyphenyl)Methylene]bis[4-[[(5-Methyl-1H-tetrazol-1-yl)iMino]Methyl]phenol (E)-2,2'-((4-Hydroxyphenyl)methylene)bis(4-((E)-(5-methyl-1H-tetrazol-1-ylimino)methyl)phenol) MDT637 MDT-637 Phenol, 2,2'-[(4-hydroxyphenyl)methylene]bis[4-[[(5-methyl-1H-tetrazol-1-yl)imino]methyl]- 235106-62-4 C25H22N10O3 Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals