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m-Toluic acid

CAS No.
99-04-7
Chemical Name:
m-Toluic acid
Synonyms
m-toluic;m-toluicaci;META-TOLUATE;m-Tlouicacid;3-TOLUIC ACID;M-TOLUIC ACID;M-TOLUYLIC ACID;3-Methylbenzoic;meta-toluicacid;M-ToluicAcid>98%
CBNumber:
CB4148782
Molecular Formula:
C8H8O2
Molecular Weight:
136.15
MDL Number:
MFCD00002523
MOL File:
99-04-7.mol
MSDS File:
SDS
Last updated:2023-08-29 17:14:30

m-Toluic acid Properties

Melting point 107-113 °C (lit.)
Boiling point 263 °C (lit.)
Density 1.054 g/mL at 25 °C (lit.)
vapor pressure 0.019Pa at 25℃
refractive index 1.509
Flash point 150 °C
storage temp. Store below +30°C.
solubility Soluble in alcohol and ether.
pka 4.27(at 25℃)
form Crystalline Solid
color Slightly yellow to beige-yellow
PH 3.69(1 mM solution);3.15(10 mM solution);2.64(100 mM solution);
Water Solubility <0.1 g/100 mL at 19 ºC
Merck 14,9535
BRN 970526
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey GPSDUZXPYCFOSQ-UHFFFAOYSA-N
LogP 2.37
CAS DataBase Reference 99-04-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 1UA7K8EEXT
NIST Chemistry Reference Benzoic acid, 3-methyl-(99-04-7)
EPA Substance Registry System m-Toluic acid (99-04-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-24/25-36
WGK Germany  3
RTECS  XU1200000
Autoignition Temperature 500 °C
TSCA  Yes
HS Code  29163900
Toxicity LD50 orally in Rabbit: 7000 mg/kg
NFPA 704
0
2 0

m-Toluic acid price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T36609 m-Toluic acid ReagentPlus , 99% 99-04-7 5g $36.4 2024-03-01 Buy
Sigma-Aldrich T36609 m-Toluic acid ReagentPlus , 99% 99-04-7 100g $51.8 2024-03-01 Buy
Sigma-Aldrich 8.21902 3-Methylbenzoic acid for synthesis 99-04-7 250g $41 2024-03-01 Buy
Sigma-Aldrich 8.21902 3-Methylbenzoic acid for synthesis 99-04-7 1kg $111 2024-03-01 Buy
TCI Chemical T0291 m-Toluic Acid >98.0%(T) 99-04-7 25g $46 2024-03-01 Buy
Product number Packaging Price Buy
T36609 5g $36.4 Buy
T36609 100g $51.8 Buy
8.21902 250g $41 Buy
8.21902 1kg $111 Buy
T0291 25g $46 Buy

m-Toluic acid Chemical Properties,Uses,Production

Description

m-toluic acid (MTA) , also known as 3-Methylbenzoic acid or m-Toluate, is a benzoic acid derivative having a floral honey odour. Benzoic acids are organic Compounds containing a benzene ring which bears at least one carboxyl group. Benzoic acid occurs naturally in many plants and its name was also derived from a plant source i.e. Gum benzoin. Although it is used as precursor to plasticizers, preservatives such as sodium benzoate, it also has wide application in many pharmaceutical preparations meant for treatment of fungal skin diseases, topical antiseptics, expectorants, analgesics and decongestants. The benzoic acid derivatives are also very useful due to their bacteriostatic and fragrant properties.
MTA is used as intermediate in various chemical reactions, MTA is used as a chemical intermediate in manufacturing of insect repellent and plastic stabilizer in the chemical industry. It is also used in the production of various chemicals like 3-carboxybenzaldehyde, 3-benzoylphenylacetic acid, 3-methylbenzophenone, and N,N-diethyl- 3-methylbenzamide etc.. It is a main component of N,N-diethylm-toluamide, commonly known as DEET, which is first insect repellent that can be applied to skin or clothing and provide protection against mosquitoes and other biting insects.

Chemical Properties

White to yellowish crystals. Ionization constant 5.3 × 10?5. Slightly soluble in water; soluble in alcohol and ether. Combustible.

Uses

Organic synthesis, to form N,N-diethyl-mtoluamide, a broad-spectrum insect repellent.

Uses

m-Toluic acid is used as a reagent in the preparation of hybrid molecules containing oxadiazole and thiadiazole bearing Schiff base moiety as it has antitumor activities.

Definition

ChEBI: M-toluic acid is a methylbenzoic acid carrying a methyl substituent at position 3. It has a role as a human xenobiotic metabolite. It is a conjugate acid of a m-toluate.

Synthesis Reference(s)

Tetrahedron, 51, p. 4991, 1995 DOI: 10.1016/0040-4020(95)98696-F
Tetrahedron Letters, 32, p. 5931, 1991 DOI: 10.1016/S0040-4039(00)79429-9

General Description

White to yellowish crystals or mostly yellow flaky solid (with some white flakes). Has a floral-honey odor.

Air & Water Reactions

Fine dust dispensed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. . Insoluble in water.

Reactivity Profile

m-Toluic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in m-Toluic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. m-Toluic acid is incompatible with strong oxidizers.

Fire Hazard

Flash point data for m-Toluic acid are not available; however, m-Toluic acid is probably combustible.

Flammability and Explosibility

Not classified

Purification Methods

Crystallise the acid from water. [Beilstein 9 IV 1712.] Aromatic acid impurities (to <0.05%) can be removed via the (±)--methylbenzylamine salt as described for 2,4-dichlorobenzoic acid [Ley & Yates Organic Process Research & Development 12 120 2008]. The S-benzylisothiuronium salt has m 140o (from aqueous EtOH).

620-22-4
99-04-7
Synthesis of m-Toluic acid from m-Tolunitrile
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View Lastest Price from m-Toluic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
m-Toluic acid pictures 2024-03-19 m-Toluic acid
99-04-7
US $0.00 / Kg/Drum 1KG 99% 500mt/year Jinan Finer Chemical Co., Ltd
M-toluic acid pictures 2023-08-29 M-toluic acid
99-04-7
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
 M-Toluic acid pictures 2023-05-04 M-Toluic acid
99-04-7
US $48.00-40.00 / KG 1KG 99% 200tons Guangzhou Sunton Biotechnology Co., Ltd.
  • m-Toluic acid pictures
  • m-Toluic acid
    99-04-7
  • US $0.00 / Kg/Drum
  • 99%
  • Jinan Finer Chemical Co., Ltd
  • M-toluic acid pictures
  • M-toluic acid
    99-04-7
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  •  M-Toluic acid pictures
  • M-Toluic acid
    99-04-7
  • US $48.00-40.00 / KG
  • 99%
  • Guangzhou Sunton Biotechnology Co., Ltd.
METHYLBENZOIC(M-) ACID beta-methylbenzoic acid 3-TOLUIC ACID 3-METHYLBENZOIC ACID RARECHEM AL BO 0048 M-TOLUIC ACID M-TOLUYLIC ACID M-METHYLBENZOIC ACID AKOS BBS-00003734 M-ToluicAcid>98% META-TOLUIC ACID FOR SYNTHESIS m-Toluicacid,99% 3-Methylbenzoic META-TOLUATE b-Methylbenzoic acid M-Toluic acid, 99% 100GR m-Toluic acid,3-Methylbenzoic acid M-Toluic acid, 99.0% m-Toluic acid ReagentPlus(R), 99% m-Toluic acid Vetec(TM) reagent grade, 98% m-Toluic acid≥ 99% (Assay) 3-Methylbenzoic acid for synthesis 3-methyl-benzoicaci Benzoicacid,3-methyl- meta-Toluic acid meta-toluicacid m-Tlouicacid m-toluic M-Methylbenzoate 3-methylbenzoate m-Toluic Acid > m-toluicaci m-Toluic acid 99.5% 3-Methylbenzoic acid(Flakes or Chunks or Granular) TIANFUCHEM--99-04-7--High purity m-Toluic acid factory price Meta Toluic Acid (3-Methyl Benzoic Acid) 99-04-7 36257 1999-4-7 1999-04-07 1999-04-7 ARYL ACID Building Blocks Organic Building Blocks C8 Carboxylic Acids Carbonyl Compounds intermediates Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Organic acids bc0001