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Telaprevir

Telaprevir
Telaprevir structure
CAS No.
402957-28-2
Chemical Name:
Telaprevir
Synonyms
VX-950;MP-424;LY-570310;Telaprevir;tellaprevir;Telaprevir-d4;Telaprevir, >=98%;VX-950(Telaprevir);VX-950 (Teleprevir);Telaprevir intermediates
CBNumber:
CB41519837
Molecular Formula:
C36H53N7O6
Formula Weight:
679.85
MOL File:
402957-28-2.mol

Telaprevir Properties

Density 
1.25
pka
11.84±0.20(Predicted)
FDA UNII
655M5O3W0U
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25
HS Code  29339900

Telaprevir Chemical Properties,Uses,Production

Description

The hepatitis C virus (HCV) protease inhibitor telaprevir (VX-950, MP- 424,LY-570310) was approved by the U.S. FDA in May 2011 for the treatment of genotype 1 chronic HCV infection in adult patients in combination with peginterferon alfa and ribavirin (PR). Telaprevir and boceprevir (vide supra) are the first two HCV protease inhibitors to be approved for treatment of HCV infection. Telaprevir is a HCV NS3-4A protease inhibitor that exerts its antiviral effect by blocking the release of nonstructural viral proteins from a polyprotein precursor. Telaprevir is a potent inhibitor of the protease (IC50=10 nM) and is active in cell culture (HCV 1b replicon assay, EC50=354 nM). Telaprevir was identified from efforts to truncate a decamer peptide inhibitor derived from the natural substrate NS5A-5B and was guided by structure-based design. The ketoamide group of telaprevir forms a covalent, reversible bond with the active site serine hydroxyl of the protease and compensates for the loss of affinity resulting from truncation of the peptide. Despite the presence of the reactive keto-amide group, telaprevir is >500-fold less potent against other serine proteases. Synthesis of the key octahydrocyclopenta[c]pyrrole-1-carboxylic acid fragment of telaprevir is achieved by a-deprotonation of Boc-protected 3-azabicyclo[3.3.0]nonane followed by reaction with CO2 and resolution of the racemic acid. Alternatively, deprotonation is carried out in the presence of a chiral amine to give the enantiomerically enriched acid.

Chemical Properties

Telaprevir is White Solid

Originator

Eli Lilly (United States)

Uses

A labelled peptidomimetic inhibitor of hepatitis C virus protease.

Uses

Telaprevir is a peptidomimetic inhibitor of hepatitis C virus protease.

Uses

Labeled Telaprevir, intended for use as an internal standard for the quantification of Telaprevir by GC- or LC-mass spectrometry.

Definition

ChEBI: An oligopeptide consisting of N-(pyrazin-2-ylcarbonyl)cyclohexylalanyl, 3-methylvalyl, octahydrocyclopenta[c]pyrrole-1-carboxy, and 3-amino-N-cyclopropyl-2-oxohexanamide residues joined in sequence. Used f r treatment of chronic hepatitis C virus genotype 1 infection.

brand name

Incivek

Telaprevir Preparation Products And Raw materials

Raw materials

Preparation Products


Telaprevir Suppliers

Global( 192)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 921 58
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19927 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21826 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3224 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24698 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58

View Lastest Price from Telaprevir manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-10-22 Telaprevir
402957-28-2
US $95.00 / Kg/Bag 10g 99% 20tons Hebei shuoxi biotechnology co. LTD
2018-07-24 Telaprevir intermediates
402957-28-2
US $10.00 / KG 100G 98% 500KG career henan chemical co

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