Telaprevir
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Telaprevir Chemical Properties,Uses,Production
Description
The hepatitis C virus (HCV) protease inhibitor telaprevir (VX-950, MP- 424,LY-570310) was approved by the U.S. FDA in May 2011 for the treatment of genotype 1 chronic HCV infection in adult patients in combination with peginterferon alfa and ribavirin (PR). Telaprevir and boceprevir (vide supra) are the first two HCV protease inhibitors to be approved for treatment of HCV infection. Telaprevir is a HCV NS3-4A protease inhibitor that exerts its antiviral effect by blocking the release of nonstructural viral proteins from a polyprotein precursor. Telaprevir is a potent inhibitor of the protease (IC50=10 nM) and is active in cell culture (HCV 1b replicon assay, EC50=354 nM). Telaprevir was identified from efforts to truncate a decamer peptide inhibitor derived from the natural substrate NS5A-5B and was guided by structure-based design. The ketoamide group of telaprevir forms a covalent, reversible bond with the active site serine hydroxyl of the protease and compensates for the loss of affinity resulting from truncation of the peptide. Despite the presence of the reactive keto-amide group, telaprevir is >500-fold less potent against other serine proteases. Synthesis of the key octahydrocyclopenta[c]pyrrole-1-carboxylic acid fragment of telaprevir is achieved by a-deprotonation of Boc-protected 3-azabicyclo[3.3.0]nonane followed by reaction with CO2 and resolution of the racemic acid. Alternatively, deprotonation is carried out in the presence of a chiral amine to give the enantiomerically enriched acid.Chemical Properties
Telaprevir is White SolidOriginator
Eli Lilly (United States)Uses
A labelled peptidomimetic inhibitor of hepatitis C virus protease.Uses
Telaprevir is a peptidomimetic inhibitor of hepatitis C virus protease.Uses
Labeled Telaprevir, intended for use as an internal standard for the quantification of Telaprevir by GC- or LC-mass spectrometry.Definition
ChEBI: An oligopeptide consisting of N-(pyrazin-2-ylcarbonyl)cyclohexylalanyl, 3-methylvalyl, octahydrocyclopenta[c]pyrrole-1-carboxy, and 3-amino-N-cyclopropyl-2-oxohexanamide residues joined in sequence. Used f r treatment of chronic hepatitis C virus genotype 1 infection.brand name
IncivekTelaprevir Preparation Products And Raw materials
Raw materials
Preparation Products
Telaprevir Suppliers
Global( 215)Suppliers
Supplier | Tel | Fax | Country | ProdList | Advantage | |
---|---|---|---|---|---|---|
Alpha Biopharmaceuticals Co., Ltd | 0086-411-39042497 |
0086-411-39042693 | sales@alphabiopharm.com | China | 896 | 58 |
Capot Chemical Co.,Ltd. | +86(0)13336195806 +86-571-85586718 |
+86-571-85864795 | sales@capotchem.com | China | 19932 | 60 |
Henan DaKen Chemical CO.,LTD. | +86-371-55531817 |
info@dakenchem.com | CHINA | 21734 | 58 | |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
010-60279497 | sales01@cooperate-pharm.com | CHINA | 1817 | 55 |
Henan Tianfu Chemical Co.,Ltd. | 0371-55170693 |
0371-55170693 | info@tianfuchem.com | CHINA | 22622 | 55 |
Hangzhou FandaChem Co.,Ltd. | 0086 158 5814 5714 (Mobile |
+86-571-56059825 | fandachem@gmail.com | CHINA | 3525 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 E-mail:sales03@shyrchem.com |
+86-21-34979012 | sales03@shyrchem.com | CHINA | 739 | 60 |
ATK CHEMICAL COMPANY LIMITED | +86 21 5161 9050/ 5187 7795 |
+86 21 5161 9052/ 5187 7796 | ivan@atkchemical.com | CHINA | 25016 | 60 |
career henan chemical co | +86-371-86658258 |
sales@coreychem.com | CHINA | 30025 | 58 | |
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 968 | 58 |
View Lastest Price from Telaprevir manufacturers
Image | Release date | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2020-12-17 |
Telaprevir/VX-950 402957-28-2 |
US $10.00 / KG | 1KG | 99%min | 20000 | Wuhan Monad Medicine Tech Co.,LTD | |
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2018-07-24 |
Telaprevir intermediates 402957-28-2 |
US $10.00 / KG | 100G | 98% | 500KG | career henan chemical co |
402957-28-2(Telaprevir)Related Search:
Pramlintide 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol CCT 137690 Tariquidar (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Torin 1 Avagacestat (BMS-708163) RO4929097 CUDC-101 Unii-U2Y5ofn795 AC480 (BMS-599626) Bortezomib Daclatasvir (BMS-790052) Veliparib Carfilzomib N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide RG7227, ITMN-191, RO5190591
- (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxaMido)acetaMido)-3,3-diMethylbutanoyl)-N-((S)-1-(cyclopropylaMino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxaMide
- Cyclopenta(c)pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydro-, (1S,3aR,6aS)-
- VX-950
- VX-950 (Teleprevir)
- (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta[c]pyrrole-1-carboxamide
- Telaprevir
- (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-6-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)-octahydrocyclopenta[c]pyrrole-1-carboxamide VX-950
- TELAPREVIR; VX-950
- VX-950(Telaprevir)
- LY-570310
- MP-424
- (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta[c]pyrrole-1-carboxamide Telaprevir(VX950)
- (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxaMido)acetaMido)-3,3-diMethylbutanoyl)-N-((R)-1-(cyclopropylaMino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxaMid
- telaprevir (VX-950) (Incivek)
- Cyclopenta(c)pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N
- Telaprevir (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta[c]pyrrole-1-carboxamide
- Telaprevir-d4
- Telaprevir, >=98%
- tellaprevir
- (1S,3aR,6aS)-N-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
- Cyclopenta(c)pyrrole-1-carboxamide
- Telaprevir intermediates
- Telaprevir, 98%, Hepatitis c virus (HCV)NS3-4Aserine protease inhibitors
- (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide
- CS-1855
- CS-61
- VX950;TELAPREVIR;VX 950
- Incivek
- (1S,3AR,6AS)-2-((S)-2-((S)-2-CYCLOHEXYL-2-(PYRAZINE-6-CARBOXAMIDO)ACETAMIDO)-3,3-DIMETHYLBUTANOYL)-N-((S)-1-(CYCLOPROPYLAMINO)-1,2-DIOXOHEXAN-3-YL)-OCTAHYDROCYCLOPENTA[C]PYRROLE-1-CARBOXAMIDE
- Cyclopenta[c]pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydro-, (1S,3aR,6aS)-
- 402957-28-2
- 402957-28-7
- C36H49D4N7O6
- Inhibitors
- VX-950
- Inhibitor
- Pharmaceutical intermediate
- Aromatics
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Isotope Labelled Compounds
- Telaprevir intermediates