Epirizole
- CAS No.
- 18694-40-1
- Chemical Name:
- Epirizole
- Synonyms
- Dalex;da-398;mebron;epirizole;mepirizol;MEPIRIZOLE;Methopyrimazole;Epirizole USP/EP/BP;4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin;2-(3-methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine
- CBNumber:
- CB4154565
- Molecular Formula:
- C11H14N4O2
- Molecular Weight:
- 234.25
- MDL Number:
- MFCD00057351
- MOL File:
- 18694-40-1.mol
- MSDS File:
- SDS
| Melting point | 90-92° |
|---|---|
| Boiling point | 376.57°C (rough estimate) |
| Density | 1.1972 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 0.65±0.50(Predicted) |
| CAS DataBase Reference | 18694-40-1(CAS DataBase Reference) |
| FDA UNII | 3B46O2FH8I |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | UV9290000 |
| Toxicity | LD50 orally in mice: 820 mg/kg (Ogura) |
Epirizole price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M9017 | Mepirizole analytical standard | 18694-40-1 | 10g | $255.2 | 2024-03-01 | Buy |
| TRC | M225093 | Mepirizole | 18694-40-1 | 100mg | $50 | 2021-12-16 | Buy |
| Usbiological | 454351 | Mepirizole | 18694-40-1 | 10g | $701 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000717 | MEPIRIZOLE 95.00% | 18694-40-1 | 10G | $1212.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000717 | MEPIRIZOLE 95.00% | 18694-40-1 | 1G | $328.65 | 2021-12-16 | Buy |
Epirizole Chemical Properties,Uses,Production
Originator
Mebron,Daiichi Seiyaku,Japan,1970
Uses
Analgesic; anti-inflammatory.
Uses
Mepirizole induces precocious differentiation of insulin-producing ti-cells in larval zebrafish. Also, it increases the expression of MDR1 mRNA in Caco-2 cells; Non-acidic analgesic.
Definition
ChEBI: Epirizole is an aromatic ether.
Manufacturing Process
A mixture of 16.3 g of 4-methyl-6-methoxy-2-pyrimidinyl-hydrazine,13.7 g of
ethyl acetoacetate and 16.3 ml of methanol was refluxed 2 hours on a water
bath. After a mixture of 4.7 g of sodium hydroxide, 4.7 ml of water and 27 ml
of methanol was added dropwise thereto at about 50°C, the reaction mixture
was refluxed for 2 hours more, then methanol was distilled off and the residue
was dissolved in 130 ml of water. The solution was adjusted to pH 6 with
acetic acid. The precipitate was filtered, washed with water and dried to give
24 g (yield: 95.3%) of crystals, MP 97° to 98°C. Recrystallization from ligroin
gave 1-(4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl-3-pyrazoline-5-one,
MP 102° to 103°C.
To a solution of 4.76 g of 1-( 4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl-
3-pyrazoline 5-one in 200 ml of ether was added an ether solution containing
6 molar equivalents of diazomethane and the reaction mixture was allowed to
stand at room temperature for 20 hours. After distilling off the solvent, the
residue was dissolved in 160 ml of water, made alkaline (pH 10) with sodium
hydroxide solution and extracted three times with 140 ml of benzene. The
extract was washed with a small amount of water, dried over sodium sulfate
and evaporated to give a crystalline mass. Recrystallization from
isopropylether gave 1-(4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl-5-
methoxypyrazole (3.96 g, 84%) as color less prisms, MP 90° to 92°C.
Therapeutic Function
Antiinflammatory, Analgesic, Antipyretic
Epirizole Preparation Products And Raw materials
Epirizole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9346 | 55 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29016 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
View Lastest Price from Epirizole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | Epirizole
18694-40-1
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-06-10 | Epirizole USP/EP/BP
18694-40-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-02-01 | Epirizole
18694-40-1
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- Epirizole
18694-40-1
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Epirizole USP/EP/BP
18694-40-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Epirizole
18694-40-1
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co