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Tetrahydropalmatine

CAS No.
2934-97-6
Chemical Name:
Tetrahydropalmatine
Synonyms
ROTUNDINUM;AKOS 208-04;ROTUNDIN HYDRATE;Rotundine CP2000;Tetrahydropalmatine;TETRAHYDROPALMITINE;TETRAHYDROPALMATINE;L-TETRAHYDROPALMATINE;Rafoxanide Impurity 5;DL-TETRAHYDROPALMATINE
CBNumber:
CB4157652
Molecular Formula:
C21H25NO4
Molecular Weight:
355.43
MDL Number:
MFCD00214191
MOL File:
2934-97-6.mol
MSDS File:
SDS
Last updated:2023-09-11 17:45:53

Tetrahydropalmatine Properties

Melting point 155℃
Boiling point 482.9±45.0 °C(Predicted)
Density 1.23±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
form Solid
pka 6.53±0.20(Predicted)
color White to Pale Yellow
FDA UNII 78F8583LNQ

SAFETY

Risk and Safety Statements

HS Code  29339900

Tetrahydropalmatine price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T3650 Tetrahydropalmatine >98.0%(HPLC)(N) 2934-97-6 1g $76 2024-03-01 Buy
TCI Chemical T3650 Tetrahydropalmatine >98.0%(HPLC)(N) 2934-97-6 5g $150 2024-03-01 Buy
Alfa Aesar J63328 Tetrahydropalmatine 98% 2934-97-6 1g $58.65 2024-03-01 Buy
Alfa Aesar J63328 Tetrahydropalmatine 98% 2934-97-6 5g $225.65 2024-03-01 Buy
Usbiological 300544 L-Tetrahydropalmatine 2934-97-6 20mg $349 2021-12-16 Buy
Product number Packaging Price Buy
T3650 1g $76 Buy
T3650 5g $150 Buy
J63328 1g $58.65 Buy
J63328 5g $225.65 Buy
300544 20mg $349 Buy

Tetrahydropalmatine Chemical Properties,Uses,Production

Description

Tetrahydropalmatine can be prepared from the total bases of tetrahydroxy berberine. Tetrahydropalmatine can be used to prepare palmatine. Palmatine has a broad-spectrum antibacterial effect, especially against Candida albicans. It can be used clinically to treat gynecological inflammation, bacillary dysentery, enteritis, respiratory and urinary tract infections, surgical infections, and conjunctivitis. Palmatine can also enhance the relaxation of the body's norepinephrine smooth muscle.
Tetrahydropalmatine, an active component isolated from corydalis, acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.

Appearance

White to Orange to Green powder to crystal

Uses

DL-Tetrahydropalmatine is the main active substance of the Chinese herb corydalis which induces hypotension and bradycardia in rats through the antagonism of striatal dopamine D2 receptor.

In vivo research

Tetrahydropalmatine (THP), an active component isolated from corydalis (a Chinese herbal medicine), possesses analgesic effects. Picrotoxin treatment alone has a significant effect on the following activity measure: there is an increase in horizontal motion time (HMT), vertical motion time (VMT), clockwise turnings (CT), anticlockwise turning (ACT) and a decrease in freezing time (FT). Tetrahydropalmatine treatment alone causes a decrease in HMT, VMT and total distance traveled (TDT), but an increase in FT. Pretreatment of rats with an i.p. dose of 10 mg/kg or 15 mg/kg of Tetrahydropalmatine significantly attenuates the Picrotoxin-induced enhancement in HMT, VMT, CT, ACT and TDT, as well as reduction in FT. Another 48 rats under urethane anesthesia are randomly divided into six groups, each of eight rats. The s.c. injection of Picrotoxin causes an increase in amygdaloid release of dopamine (DA), while i.p. injection of Tetrahydropalmatine at 10 mg/kg has an insignificant effect on amygdaloid release of DA. Again, the Picrotoxin-induced increase in amygdaloid release of DA is significantly attenuated by pretreatment with Tetrahydropalmatine. The Picrotoxin-induced augmented amygdaloid release of DA is almost completely abolished by pretreatment with Tetrahydropalmatine 30 min before s.c. injection of Picrotoxin.

Preparation

A. Berberine hydrochloride is ring-opened under the conditions of p-toluenesulfonic acid, xylene, and HCl at 70°C to obtain desmethylene berberine hydrochloride.
B. Demethylene berberine hydrochloride is methyl etherified with potassium carbonate, methanol, and dimethyl sulfate at 40°C to obtain palmatine hydrochloride.
C. Palmatine hydrochloride is racemized under the conditions of methanol and sodium borohydride to obtain tetrahydropalmatine.

Uses

analgesic, hypnotic, papaverine-like

Uses

DL-Tetrahydropalmatine is the main active substance of the Chinese herb corydalis which induces hypotension and bradycardia in rats through the antagonism of striatal dopamine D2 receptor.

Definition

ChEBI: 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline is an alkaloid.

109806-78-2
2934-97-6
Synthesis of Tetrahydropalmatine from Benzeneethanamine, N-[(2,3-dimethoxyphenyl)methylene]-3,4-dimethoxy-

Tetrahydropalmatine Preparation Products And Raw materials

Global( 156)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Haibo Biotechnology Co., Ltd
+86-02963020060 +86-18629295024 hibo06@xaltbio.com China 1000 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897 sales@biopurify.com China 3424 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768 sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Xi'an Kono chem co., Ltd.,
029-86107037 13289246953 info@konochemical.com China 2995 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shanghai Standard Technology Co., Ltd.
18502101150 ft-sales@nature-standard.com CHINA 1923 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58

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View Lastest Price from Tetrahydropalmatine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Corydalis yanhusuo extract Tetrahydropalmatine powder pictures 2023-11-08 Corydalis yanhusuo extract Tetrahydropalmatine powder
2934-97-6
US $0.00-0.00 / KG 1KG 10: 1,Lepidium meyenii Walp 10000kg/Month Shaanxi Haibo Biotechnology Co., Ltd
Tetrahydropalmatine pictures 2023-02-24 Tetrahydropalmatine
2934-97-6
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
DL-tetrahydropalMatine pictures 2021-09-29 DL-tetrahydropalMatine
2934-97-6
US $0.00-0.00 / Kg/Drum 1KG 98%min 100KGS WUHAN FORTUNA CHEMICAL CO., LTD
TETRAHYDROPALMATINE, L- (S)-2,3,9,10-TETRAMETHOXY-5,8,13,13A-TETRAHYDRO-6H-ISOQUINO[3,2-A]ISOQUINOLINE ROTUNDINUM ROTUNDIN HYDRATE AKOS 208-04 L-TETRAHYDROPALMATINE TETRAHYDROPALMITINE 6H-Dibenzo[a,g]quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy- (±)-2,3,9,10-Tetramethoxyberbine Tetrahydropalmatine (R,S)-TetrahydropalMatine TETRAHYDROPALMATINE, DL-(P) Rotundine CP2000 DL-TETRAHYDROPALMATINE TETRAHYDROPALMATINE 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline DL-Tetrahydropalmatine, 98%, from Corydalis yanhusuo W. T. Wang ex Z. Y. Su et C. Y. Wu Tetrahydropalmatine (DL-Tetrahydropalmatine) Tetrahydropalmatine Solution in Water/Acetonitrile,1000μg/mL 2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline DL-TETRAHYDROPALMATINE USP/EP/BP Rafoxanide Impurity 5 Corydalis yanhusuo extract Tetrahydropalmatine powder TETRAHYDROPALMATINE, DL- 2934-97-6 Inhibitors