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Tetrahydropalmatine

Description Appearance Uses In vivo research Preparation
Tetrahydropalmatine
Tetrahydropalmatine structure
CAS No.
2934-97-6
Chemical Name:
Tetrahydropalmatine
Synonyms
ROTUNDINUM;AKOS 208-04;ROTUNDIN HYDRATE;Rotundine CP2000;Tetrahydropalmatine;TETRAHYDROPALMITINE;TETRAHYDROPALMATINE;L-TETRAHYDROPALMATINE;DL-TETRAHYDROPALMATINE;TETRAHYDROPALMATINE, L-
CBNumber:
CB4157652
Molecular Formula:
C21H25NO4
Formula Weight:
355.43
MOL File:
2934-97-6.mol

Tetrahydropalmatine Properties

Melting point:
155℃
Boiling point:
482.9±45.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
6.53±0.20(Predicted)
SAFETY
  • Risk and Safety Statements
HS Code  29339900

Tetrahydropalmatine price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T3650 Tetrahydropalmatine >98.0%(HPLC)(N) 2934-97-6 1g $38 2021-03-22 Buy
TCI Chemical T3650 Tetrahydropalmatine >98.0%(HPLC)(N) 2934-97-6 5g $76 2021-03-22 Buy
Alfa Aesar J63328 Tetrahydropalmatine 98% 2934-97-6 5g $205 2021-03-22 Buy
Alfa Aesar J63328 Tetrahydropalmatine 98% 2934-97-6 1g $57.2 2021-03-22 Buy

Tetrahydropalmatine Chemical Properties,Uses,Production

Description

Tetrahydropalmatine can be prepared from the total bases of tetrahydroxy berberine. Tetrahydropalmatine can be used to prepare palmatine. Palmatine has a broad-spectrum antibacterial effect, especially against Candida albicans. It can be used clinically to treat gynecological inflammation, bacillary dysentery, enteritis, respiratory and urinary tract infections, surgical infections, and conjunctivitis. Palmatine can also enhance the relaxation of the body's norepinephrine smooth muscle.
Tetrahydropalmatine, an active component isolated from corydalis, acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.

Appearance

White to Orange to Green powder to crystal

Uses

DL-Tetrahydropalmatine is the main active substance of the Chinese herb corydalis which induces hypotension and bradycardia in rats through the antagonism of striatal dopamine D2 receptor.

In vivo research

Tetrahydropalmatine (THP), an active component isolated from corydalis (a Chinese herbal medicine), possesses analgesic effects. Picrotoxin treatment alone has a significant effect on the following activity measure: there is an increase in horizontal motion time (HMT), vertical motion time (VMT), clockwise turnings (CT), anticlockwise turning (ACT) and a decrease in freezing time (FT). Tetrahydropalmatine treatment alone causes a decrease in HMT, VMT and total distance traveled (TDT), but an increase in FT. Pretreatment of rats with an i.p. dose of 10 mg/kg or 15 mg/kg of Tetrahydropalmatine significantly attenuates the Picrotoxin-induced enhancement in HMT, VMT, CT, ACT and TDT, as well as reduction in FT. Another 48 rats under urethane anesthesia are randomly divided into six groups, each of eight rats. The s.c. injection of Picrotoxin causes an increase in amygdaloid release of dopamine (DA), while i.p. injection of Tetrahydropalmatine at 10 mg/kg has an insignificant effect on amygdaloid release of DA. Again, the Picrotoxin-induced increase in amygdaloid release of DA is significantly attenuated by pretreatment with Tetrahydropalmatine. The Picrotoxin-induced augmented amygdaloid release of DA is almost completely abolished by pretreatment with Tetrahydropalmatine 30 min before s.c. injection of Picrotoxin.

Preparation

A. Berberine hydrochloride is ring-opened under the conditions of p-toluenesulfonic acid, xylene, and HCl at 70°C to obtain desmethylene berberine hydrochloride.
B. Demethylene berberine hydrochloride is methyl etherified with potassium carbonate, methanol, and dimethyl sulfate at 40°C to obtain palmatine hydrochloride.
C. Palmatine hydrochloride is racemized under the conditions of methanol and sodium borohydride to obtain tetrahydropalmatine.

Uses

analgesic, hypnotic, papaverine-like

Tetrahydropalmatine Preparation Products And Raw materials

Raw materials

Preparation Products


Tetrahydropalmatine Suppliers

Global( 129)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1923 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58

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View Lastest Price from Tetrahydropalmatine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-29 DL-tetrahydropalMatine
2934-97-6
US $0.00-0.00 / Kg/Drum 1KG 98%min 100KGS WUHAN FORTUNA CHEMICAL CO., LTD
2021-07-20 ROTUNDINUM
2934-97-6
US $1.00-1.00 / Kg/Bag 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2021-06-11 DL-TETRAHYDROPALMATINE USP/EP/BP
2934-97-6
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited

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