(+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID
- CAS No.
- 88852-33-9
- Chemical Name:
- (+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID
- Synonyms
- (+/-)15-HEPE;WLKCSMCLEKGITB-XWJJKCKWSA-N;15-hydroxy-eicosa-5Z,8Z,11Z,13E,17Z-pentaenoic acid;(+/-)-15-Hydroxy-5Z,8Z,11Z,13E,17Z-eicosadienoic acid;(+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID;(+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID;5,8,11,13,17-Eicosapentaenoic acid, 15-hydroxy-, (5Z,8Z,11Z,13E,17Z)-
- CBNumber:
- CB4160353
- Molecular Formula:
- C20H30O3
- Molecular Weight:
- 318.45
- MDL Number:
- MFCD00216118
- MOL File:
- 88852-33-9.mol
| Boiling point | 488.0±45.0 °C(Predicted) |
|---|---|
| Density | 0.997±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml |
| pka | 4.75±0.10(Predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| NFPA 704 |
|
(+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 32700 | (±)15-HEPE ≥98% | 88852-33-9 | 25μg | $95 | 2024-03-01 | Buy |
| Cayman Chemical | 32700 | (±)15-HEPE ≥98% | 88852-33-9 | 50μg | $181 | 2024-03-01 | Buy |
| Cayman Chemical | 32700 | (±)15-HEPE ≥98% | 88852-33-9 | 100μg | $342 | 2024-03-01 | Buy |
| AHH | MT-15004 | (+/-)-15-Hydroxy-5Z,8Z,11Z,13E,17Z-eicosadienoic acid 98% | 88852-33-9 | 0.001g | $645 | 2021-12-16 | Buy |
(+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID Chemical Properties,Uses,Production
Description
(±)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE . 15(S)-HEPE is formed from EPA via a 15(S)-HpEPE intermediate, which is produced by 15-lipoxygenase (15-LO) and reduced by glutathione peroxidase (GPX).1,2 (±)15-HEPE is active against P. acnes and S. aureus (MICs = 128 and 512 mg/L, respectively).3 It inhibits aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP (IC50 = 4.7 μM).4 Bronchoalveolar lavage fluid (BALF) levels of (±)15-HEPE are increased in patients with allergic asthma or COVID-19.5,6
Definition
ChEBI: 15-HEPE is a hydroxyicosapentaenoic acid that consists of 5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid bearing an additional 15-hydroxy substituent. It has a role as a mouse metabolite. It is a HEPE and a hydroxy polyunsaturated fatty acid.
References
1. Miller, C., Yamaguchi, R.Y., and Ziboh, V.A. Guinea pig epidermis generates putative anti-
2. Tan, L., Xin, X., Zhai, L., et al. Drosophila fed ARA and EPA yields eicosanoids, 15S-
3. Desbois, A.P., and Lawlor, K.C. Antibacterial activity of long-
4. Lam, B., Marcinkiewicz, E., and Wong, P.Y.-K. Transformation of 15-
5. Lundstr?m, S.L., Yang, J., K?llberg, H.J., et al. Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation PLoS One 7(3),e33780(2012).
6. Archambault, A.-S., Zaid, Y., Rakotoarivelo, V., et al. High levels of eicosanoids and docosanoids in the lungs of intubated COVID-
(+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
(+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
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| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 18521735133 18521732826; | market@aladdin-e.com | China | 25015 | 65 |
| Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | root@zhongyitai.com | China | 1976 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| amyjetsci | 027-59626688 18771149750 | sales@amyjet.com | China | 3004 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |