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TERBUTALINE SULFATE

TERBUTALINE SULFATE
TERBUTALINE SULFATE structure
CAS No.
23031-32-5
Chemical Name:
TERBUTALINE SULFATE
Synonyms
TERBUL;Convon;bricanyl;MONOVENT;BRETHINE;Brithine;Butalire;fate saL;TerbutaL;TERBASMIN
CBNumber:
CB4164487
Molecular Formula:
C24H40N2O10S
Formula Weight:
548.65
MOL File:
23031-32-5.mol

TERBUTALINE SULFATE Properties

Melting point:
246-248°C
Density 
1.1840 (rough estimate)
refractive index 
1.6900 (estimate)
storage temp. 
2-8°C
solubility 
H2O: soluble100mg/mL, clear to slightly hazy, colorless to yellow
pka
pKa1 8.8, pKa2 10.1, pKa3 11.2(at 25℃)
form 
neat
InChIKey
KFVSLSTULZVNPG-UHFFFAOYSA-N
FDA UNII
576PU70Y8E
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361
Precautionary statements  P280-P281
Hazard Codes  Xn
Risk Statements  42/43-63
Safety Statements  26-36
WGK Germany  3
RTECS  DN9000000
HS Code  2922504500

TERBUTALINE SULFATE price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T2528 Terbutaline hemisulfate salt 23031-32-5 1g $67.6 2021-12-16 Buy
Sigma-Aldrich T0050000 Terbutaline sulfate European Pharmacopoeia (EP) Reference Standard 23031-32-5 $190 2021-12-16 Buy
Sigma-Aldrich 1643500 Terbutaline sulfate United States Pharmacopeia (USP) Reference Standard 23031-32-5 125mg $297 2021-12-16 Buy
Cayman Chemical 21292 Terbutaline (hemisulfate) 23031-32-5 5mg $116 2021-12-16 Buy
Cayman Chemical 21292 Terbutaline (hemisulfate) 23031-32-5 1mg $29 2021-12-16 Buy

TERBUTALINE SULFATE Chemical Properties,Uses,Production

Description

Terbutaline is the N-t-butyl analogue of metaproterenol and, as such, would be expected to have a more potent β2-selectivity. When compared to metaproterenol, terbutaline has a threefold greater potency at the β2-receptor. Like metaproterenol, it is resistant to COMT and slowly metabolized by MAO, therefore having good oral bioavailability with similar onset and duration. Terbutaline is available as tablets and solutions for injection and inhalation. Adverse effects are similar to other direct-acting β2-selective agonists, however, with a greater incidence of palp

Description

Terbutaline (hemisulfate) (Item No. 21292) is an analytical reference standard categorized as a β2-adrenergic receptor agonist. Terbutaline has been used to enhance physical performance in athletes. This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 29337).

Chemical Properties

White or almost white, crystalline powder.

Originator

Bricanyl,Pharma-Stern,W. Germany,1971

Uses

betaadrenergic agonist, bronchodilator

Uses

Anti Asthmatic

Uses

A B-Adrenergic receptor agonist. A Bronchodilator

Manufacturing Process

To a solution of 32 g of benzyl-t-butylamine in 300 ml of absolute ethanol at reflux temperature was added 32 g of 3,5-dibenzyloxy-?-bromoacetophenone in 10 ml of dry benzene. The mixture was refluxed for 20 hours and then evaporated. When absolute ether was added to the residue, benzyl-tbutylamine hydrobromide was precipitated. The precipitated compound was filtered off and to the filtrate was added an excess of 2 N sulfuric acid. This caused precipitation of the hydrogen sulfate of 3,5-dibenzyloxy-?-(benzyl-tbutylamino)- acetophenone which was recrystallized from acetone/ether. If the product is crystallized from different organic solvents, the melting point will vary with the type and amount of solvent of crystallization, but the product can be used directly for hydrogenation.
15 g of 3,5-dibenzyloxy-?-(benzyl-t-butylamino)-acetophenone hydrogen sulfate in 200 ml of glacial acetic acid were hydrogenated in a Parr pressure reaction apparatus in the presence of 1.5 g of 10% palladium charcoal at 50°C and 5 atmospheres pressure. The reaction time was 5 hours. The catalyst was filtered off, the filtrate was evaporated to dryness and the hydrogen sulfate of 1-(3',5'-dihydroxyphenyl)-2-(t-butylamino)-ethanol was received. This compound is hygroscopic, but it can be transformed into a nonhygroscopic sulfate in the following manner.
The hydrogen sulfate was dissolved in water and the pH of the solution was adjusted to 5.6 (pH-meter) with 0.1 N sodium hydroxide solution. The water solution was evaporated to dryness and the residue dried with absolute ethanol/benzene and once more evaporated to dryness. The remaining crystal mixture was extracted in a Soxhlet extraction apparatus with absolute methanol. From the methanol phase the sulfate of 1-(3',5'-dihydroxyphenyl)- 2-(t-butylamino)-ethanol crystallized. Melting point 246°C to 248°C.

brand name

Terbutaline is INN and BAN.

Therapeutic Function

Bronchodilator

Veterinary Drugs and Treatments

Terbutaline is used as a bronchodilating agent in the adjunctive treatment of cardiopulmonary diseases (including tracheobronchitis, collapsing trachea, pulmonary edema, and allergic bronchitis) in small animals. It may be of some benefit in treating bradyarrhythmias in dogs and cats.
Terbutaline has been used occasionally in horses for its bronchodilating effects, but adverse effects, short duration of activity after IV administration and poor oral absorption have limited its use. It has been shown to be useful as a diagnostic agent to diagnose anhidrosis in horses after intradermal injection.
Oral and intravenous terbutaline has been used successfully in humans for the inhibition of premature labor clinical signs.

TERBUTALINE SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products


TERBUTALINE SULFATE Suppliers

Global( 200)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9143 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
Shaanxi Dideu Medichem Co. Ltd
18192627656
+86-29-88380327 1012@dideu.com CHINA 3949 58
Shaanxi Dideu Medichem Co. Ltd
15319487004
029-88380327 1015@dideu.com CHINA 3994 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
86-021-61999440
contact@trustwe.com CHINA 10008 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17384 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19231 58
Hubei Ipure Biology Co., Ltd
+8618062405514
18062427325 ada@ipurechemical.com;ada@ipurechemical.com China 10352 58

View Lastest Price from TERBUTALINE SULFATE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-29 Terbutaline Sulfate
23031-32-5
US $0.00-0.00 / Kg/Drum 1KG 98%-101%; BP 100KGS WUHAN FORTUNA CHEMICAL CO., LTD
2021-07-02 TERBUTALINE SULFATE
23031-32-5
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-05-29 TERBUTALINE SULFATE USP/EP/BP
23031-32-5
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited

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