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Diisobutylaluminium hydride

CAS No.
1191-15-7
Chemical Name:
Diisobutylaluminium hydride
Synonyms
DIBAL-H;Dibal;DIISOBUTYLALUMINUM HYDRIDE;DIBAH;Diisobutylaluminum;Bis(2-methylpropyl)alumane;Bisisobutylaluminum;Diisobutylaluminum hydrid;diisobutylaluminum hydride solution;DiisobutylaluMinuM hydride solution 1.0 M in cyclohexane
CBNumber:
CB4171924
Molecular Formula:
C8H19Al
Molecular Weight:
142.22
MDL Number:
MFCD00008928
MOL File:
1191-15-7.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06

Diisobutylaluminium hydride Properties

Melting point -70 °C
Boiling point 65 °C
Density 1.23 g/mL at 25 °C
vapor pressure 13.3Pa at 90℃
Flash point 40 °F
storage temp. 2-8°C
solubility Miscible with organic solvents.
form Solution
color Clear
Specific Gravity 0.860
Water Solubility vigorous reaction
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents
Sensitive Air Sensitive/Heat Sensitive
BRN 4123663
Exposure limits ACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
InChIKey AZWXAPCAJCYGIA-UHFFFAOYSA-N
LogP 4.22
CAS DataBase Reference 1191-15-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII H2EJ47H11A
NIST Chemistry Reference Diisobutylaluminum hydride(1191-15-7)
EPA Substance Registry System Diisobutylaluminum hydride (1191-15-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H225-H250-H260-H304-H314-H336-H361d-H373-H412
Precautionary statements  P210-P231+P232-P280-P301+P310+P331-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310-P370+P378
Hazard Codes  F,T,C,N
Risk Statements  14/15-17-35-40-67-65-63-48/20-11-34-19-62-51/53-23/24/25-20/21/22-15-14-50/53-37-22
Safety Statements  26-43-45-62-46-36/37/39-29-16-61-27-9
RIDADR  UN 3399 4.3/PG 1
WGK Germany  2
RTECS  BD0710000
1-4.3-10
TSCA  Yes
HazardClass  4.3
PackingGroup  I
HS Code  29319090
NFPA 704
3
0 3

Diisobutylaluminium hydride price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 214981 Diisobutylaluminum hydride solution 1.0?M in THF 1191-15-7 4X25ML $102 2024-03-01 Buy
Sigma-Aldrich 214981 Diisobutylaluminum hydride solution 1.0?M in THF 1191-15-7 18L $2160 2024-03-01 Buy
Sigma-Aldrich 190306 Diisobutylaluminum hydride solution 1.0M in hexanes 1191-15-7 100ml $62.6 2024-03-01 Buy
Sigma-Aldrich 190306 Diisobutylaluminum hydride solution 1.0M in hexanes 1191-15-7 4x100ml $215 2024-03-01 Buy
Alfa Aesar H37108 Diisobutylaluminumhydride,1.1Mincyclohexane packagedunderNitrogeninresealableAcroSeal[tbottles 1191-15-7 100ml $64.5 2024-03-01 Buy
Product number Packaging Price Buy
214981 4X25ML $102 Buy
214981 18L $2160 Buy
190306 100ml $62.6 Buy
190306 4x100ml $215 Buy
H37108 100ml $64.5 Buy

Diisobutylaluminium hydride Chemical Properties,Uses,Production

Description

Diisobutylaluminium hydride (DIBALH, DIBAL, DIBAL-H or DIBAH) is a reducing agent with the formula (i-Bu2AlH)2, where i-Bu represents isobutyl (-CH2CH(CH3)2). It can be used for various homogeneous reductions such as alkynes to alkenes, esters or nitriles to aldehydes. It is available commercially as the neat reagent and as a solution in several different solvents (hexane, dichloromethane, tetrahydrofuran, etc.). The neat reagent is a liquid and is supplied in metal cylinders. It is pyrophoric and highly reactive and therefore must be handled with great care. The molar solutions in organic solvents are more stable and easier to handle provided that the normal precautions are taken for working with air-sensitive compounds. They must all be handled in an atmosphere free from oxygen and water. Commonly used solvents for diisobutylaluminium hydride are dichloromethane, diglyme, dioxane and tetrahydrofuran. Even when the substrate is not completely soluble in these solvents successful reductions can be accomplished.

Chemical Properties

Diisobutylaluminium hydride, also known as Dibal. colorless liquid. Viscosity 18.0mPa-s(25℃). Reacts violently with water to form hydrogen and isobutane. Tetrahydrofuran is not suitable as Dibal solvent, because the two react to produce coordination compounds. Diisobutylaluminium hydride is a useful reducing agent in organic synthesis. It can reduce ketones, carboxylic acids and esters to the corresponding alcohols. Dibal can also reduce lactones to o-hydroxy lactones.

Uses

Diisobutylaluminum hydride is used as reducing agent in pharmaceuticals. It is also used as raw material in organic synthesis, agrochemicals and dyestuffs.

Uses

Diisobutylaluminum hydride (DIBAL-H) is a common reducing agent to reduce aldehydes, ketones, esters, acids and acid chlorides to the corresponding alcohols. Some of the applications are:
Synthesis of α-acetoxy ethers by reduction and subsequent acetylation of esters.
Synthesis of coniferyl, sinapyl, and p-coumaryl alcohol by selective reduction of corresponding cinnamate esters.
Reduction of secondary phosphine oxides (SPOs) to the corresponding phosphines.
DIBAL-H can also be used in the hydroalumination of alkene and alkynes.

Uses

Diisobutylaluminum hydride is commonly used as a reducing agent in organic synthesis.
Diisobutylaluminum hydride can be used in the following protocols:
As a promotor of Tishchenko reaction of aldehydes.
Conversion of benzylidene acetals of 1,2-and 1,3-glycols to the corresponding monobenzyl ethers of the glycols.
To generate a novel chiral reducing agent based on (S)-proline for the asymmetric reduction of prochiral ketones.

Flammability and Explosibility

Spontaneously flammable in air (pyrophoric)

Safety Profile

Mddly toxic by inhalation. Dangerous fire hazard; iptes spontaneously in air. To fight fire, do not use water, foam, or halogenated extinguisking agents. See also HYDRIDES and ALUMINUM COMPOUNDS.

Global( 285)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Richest Group Ltd
18017061086 oled@richest-group.com CHINA 5601 58

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View Lastest Price from Diisobutylaluminium hydride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Diisobutylaluminium hydride pictures 2023-04-11 Diisobutylaluminium hydride
1191-15-7
US $90.00 / kg 1kg 99% 100 tons Hebei Duling International Trade Co. LTD
Diisobutylaluminium hydride pictures 2021-11-11 Diisobutylaluminium hydride
1191-15-7
US $10.00 / KG 1KG 99% 5tons Hebei Guanlang Biotechnology Co., Ltd.
Diisobutylaluminium hydride pictures 2019-07-06 Diisobutylaluminium hydride
1191-15-7
US $1.00 / KG 10KG 99% 20KG Career Henan Chemical Co
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