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CHAETOMIN

CHAETOMIN Structure
CHAETOMIN structure
CAS No.
1403-36-7
Chemical Name:
CHAETOMIN
Synonyms
CTM;CS-1;HSF4;SSFA2;CHETOMIN;CHAETOMIN;NSC 289491;CHETOMIN(RG);DKFZp313O1039;Chetomin,Chaetomin
CBNumber:
CB4173948
Molecular Formula:
C31H30N6O6S4
Molecular Weight:
710.87
MDL Number:
MFCD28137713
MOL File:
1403-36-7.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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CHAETOMIN Properties

Melting point 218-220℃ (chloroform )
Density 1.78±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble
form Off-white to fawn solid.
pka 12.69±0.10(Predicted)
color Off-white to fawn
EWG's Food Scores 1
FDA UNII BKU7CX6USX

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
Toxicity rat,LD50,oral,75mg/kg (75mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 174, 1980.
NFPA 704
0
2 0

CHAETOMIN price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C9623 Chetomin from Chaetomium cochliodes, ≥98% (HPLC) 1403-36-7 1mg $265 2024-03-01 Buy
Sigma-Aldrich SAB1403947 Monoclonal Anti-HSF4 antibody produced in mouse clone 3G3, purified immunoglobulin, buffered aqueous solution 1403-36-7 100μg $524 2024-03-01 Buy
Sigma-Aldrich C9623 Chetomin from Chaetomium cochliodes, ≥98% (HPLC) 1403-36-7 5mg $792 2024-03-01 Buy
Cayman Chemical 14437 Chetomin ≥95% 1403-36-7 1mg $184 2024-03-01 Buy
Cayman Chemical 14437 Chetomin ≥95% 1403-36-7 5mg $549 2024-03-01 Buy
Product number Packaging Price Buy
C9623 1mg $265 Buy
SAB1403947 100μg $524 Buy
C9623 5mg $792 Buy
14437 1mg $184 Buy
14437 5mg $549 Buy

CHAETOMIN Chemical Properties,Uses,Production

Uses

Chetomin is an antibacterial agent and inhibitor of HIF.

Definition

ChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.

Biochem/physiol Actions

Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.

storage

+4°C

CHAETOMIN Preparation Products And Raw materials

Raw materials

Preparation Products

CHAETOMIN Suppliers

Global( 94)Suppliers
Supplier Tel Email Country ProdList Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
BOC Sciences 		+16314854226 inquiry@bocsci.com United States 19743 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35906 56
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2784 58
TargetMol Chemicals Inc. 021-33632979 15002134094 marketing@targetmol.com China 7934 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
BOC Sciences 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
AdooQ BioScience, LLC 58
TargetMol Chemicals Inc. 58
Sigma-Aldrich 80

1403-36-7(CHAETOMIN)Related Search:

Chrysin QUINOMYCIN A Anifostine trihydrate BISPHENOL A DIMETHYL ETHER (3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE
(3R)-(+)-3-(ETHYLAMINO)PYRROLIDINE [2-(4-METHYLPIPERAZINYL)-1-PHENYLETHYL]METHYLAMINE 1H-Indol-2-amine 1-Piperazineethanamine,-alpha-,-alpha-,4-trimethyl-(9CI) HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE
CHAETOMIN BENZENEMETHANAMINE, 2-AMINO-ALPHA,ALPHA-DIMETHYL CHEMBRDG-BB 4012298 2-(3-PHENYL-PYRROLIDIN-1-YL)-ETHYLAMINE CYCLO(-D-ALA-D-ALA)
2-(4-METHYLPIPERAZINYL)-1-PHENYLETHYLAMINE (S)-2-HYDROXYMETHYL-PIPERAZINE 1,2-BIS(DIMETHYLAMINO)-2-METHYLPROPANE

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Monoclonal Anti-HSF4 antibody produced in mouse DKFZp313O1039 SSFA2 ANTI-HSF4 antibody produced in mouse HSF4 CTM CS-1 CHETOMIN CHAETOMIN Chetomin,Chaetomin Chetomin,Chaetomiumspecies CHETOMIN(RG) NSC 289491 Stereoisomer of 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione (3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione Chetomin (NSC 289491) 3,11a-Epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione, 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-, (3S,5aR,10bS,11aS)- NSC289491， BRN0077366 Rabbit Anti-HSF4 antibody 1403-36-7 C31H30N6O6S4