ChemicalBook
Chinese Japanese Germany Korea

1,8-Dihydroxyanthraquinone

1,8-Dihydroxyanthraquinone
1,8-Dihydroxyanthraquinone structure
CAS No.
117-10-2
Chemical Name:
1,8-Dihydroxyanthraquinone
Synonyms
LTAN;Istin;ALTAN;Duolax;Modane;prugol;roydan;Dorbane;Dionone;Laxipur
CBNumber:
CB4173988
Molecular Formula:
C14H8O4
Formula Weight:
240.21
MOL File:
117-10-2.mol

1,8-Dihydroxyanthraquinone Properties

Melting point:
191-193 °C (lit.)
Boiling point:
342.92°C (rough estimate)
Density 
1.3032 (rough estimate)
refractive index 
1.5430 (estimate)
Flash point:
>200°C
storage temp. 
Sealed in dry,2-8°C
pka
6.27±0.20(Predicted)
form 
Powder
color 
Orange-brown or brown
Water Solubility 
insoluble
Merck 
14,2815
BRN 
2054727
CAS DataBase Reference
117-10-2(CAS DataBase Reference)
FDA 21 CFR
310.545
EWG's Food Scores
2
FDA UNII
Z4XE6IBF3V
Proposition 65 List
Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone)
IARC
2B (Vol. 50) 1990
NIST Chemistry Reference
1,8-Dihydroxyanthraquinone(117-10-2)
EPA Substance Registry System
Danthron (117-10-2)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H319-H351-H320
Precautionary statements  P201-P202-P264-P280-P305+P351+P338+P337+P313-P308+P313-P405-P501-P501a-P281-P305+P351+P338
Hazard Codes  Xn
Risk Statements  40
Safety Statements  36/37-36-22
RIDADR  2811
WGK Germany  1
RTECS  CB6650000
TSCA  Yes
HazardClass  IRRITANT
HS Code  29146990
Toxicity LD50 orally in mice: <7 g/kg (Case)
NFPA 704
1
2 0

1,8-Dihydroxyanthraquinone price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.22028 1,8-Dihydroxyanthraquinone for synthesis 117-10-2 100 g $31.63 2021-03-22 Buy
Sigma-Aldrich D108103 1,8-Dihydroxyanthraquinone 96% 117-10-2 100g $71.5 2021-03-22 Buy
Sigma-Aldrich D108103 1,8-Dihydroxyanthraquinone 96% 117-10-2 500g $138 2021-03-22 Buy
TCI Chemical D0563 Chrysazin >98.0%(T) 117-10-2 25g $95 2021-03-22 Buy
Alfa Aesar A12001 1,8-Dihydroxyanthraquinone, 95% 117-10-2 500g $121 2021-03-22 Buy

1,8-Dihydroxyanthraquinone Chemical Properties,Uses,Production

Description

Danthron, a natural product, was originally extracted from the roots and rhizome of Polygonaceae plant, also called Da Huang in traditional Chinese herbal medicine. Now it is synthesized in many countries, such as Germany, India, Japan, Poland, the United Kingdom, and the United States. Danthron is reasonably anticipated to be a human carcinogen.
Danthron is an anthraquinone that exists at room temperature as a red or orange crystalline powder.It is practically insoluble in water, but soluble in a variety of solvents (acetone, chloroform, diethyl ether, ethanol) and alkaline hydroxide solutions. The stability of danthron is generally good. It is stable under room temperatures and normal pressures.

Chemical Properties

orange-brown or brown powder

Chemical Properties

Red-orange to orange crystalline powder or reddish-brown crystalline solid.

Uses

Important intermediate in the manufacture of alizarin and indanthrene dyestuffs; forms insoluble Ca, Ba, Pb lakes. Antioxidant in synthetic lubricants; fungicide.

Uses

Used as a stimulant laxative, though due to its carcinogenic properties, is not widely prescribed.

Uses

cathartic

Definition

ChEBI: A dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 8.

brand name

Dorbane (3M Pharmaceuticals); Istizin (Sterling Winthrop);Doss;Normax;Regulex-d.

World Health Organization (WHO)

Dantron, an anthroquinone derivative, has been available for over twenty years and is widely used as a laxative. The results of two chronic toxicity studies in rodents, published in 1985 and 1986, have shown that administration of high doses is associated with the development of intestinal and liver tumours.

General Description

Orange crystalline powder. Almost odorless and tasteless.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

1,8-Dihydroxyanthraquinone is incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides.

Fire Hazard

Flash point data for 1,8-Dihydroxyanthraquinone are not available; however, 1,8-Dihydroxyanthraquinone is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by intraperitoneal route. An eye irritant. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Human mutation data reported. A laxative. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

A potential liver carcinogen and possible narcotic, this compound is no longer sold or marketed in the United States Nervous system toxin-acute effects; Respiratory toxin-acute effects other than severe or moderate irritation; Liver-acute effects; Eye irritant-mild.

Carcinogenicity

Danthron is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Danthron can cause DNA damage particularly at guanines in the 5'-GG-3', 5'-GGGG-3', 5'-GGGGG-3' sequences in the presence of Cu(II), cytochrome P450 reductase and the nicotinamide adenine dinucleotide phosphate (NADPH)-generating system. H2O2 and Cu(I) may also be involved because this DNA damage can be inhibited by catalase and bathocuproine. The further mechanism is danthron is reduced by P450 reductase and generate reactive oxygen species through the redox cycle, leading to extensive Cu(II)-mediated DNA damage. The DNA damage also comes from similar topoisomerase II inhibitor behavior of danthron.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise Danthrone from EtOH and sublime it in a vacuum. [Beilstein 8 IV 3217.]

Toxicity evaluation

Danthron is discovered in several species of plants and insects. It has been isolated from dried leaves and stems of Xyris semifuscata harvested in Madagascar, and roots of Da Huang, a Chinese traditional herbal medicine. Danthron also appears to be biosynthesized by some insects. The presence of danthron in insects may be a way of protection from predators. Danthron can be manually synthesized by many countries. In the United States, danthron was available from 12 suppliers.
If released to the atmosphere, danthron will exist in both the vapor phase and the particulate phase. Vapor phase danthron has an estimated half-life of 11 days. Particulate phase danthron can be physically removed from air by wet and dry deposition. It is expected to biodegrade with 68% degradation within 3 months.
If released to water, danthron is expected to adsorb to the surface of solid particle and sediment. Biodegradation is also a major pathway processed in water. It was reported that 82% of the added danthron was degraded by fresh water within 3 days. If added to seawater, 91% of danthron was reported as degraded. Danthron may bioconcentrate in aquatic organisms, such as fish and shrimps.

Incompatibilities

Keep away from strong reducing agents, such as hydrides, nitrides, alkali metals, and sulfides.

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double- bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to prop- erly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

1,8-Dihydroxyanthraquinone Preparation Products And Raw materials

Raw materials

Preparation Products


1,8-Dihydroxyanthraquinone Suppliers

Global( 314)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hi-Tech Chemistry Corp
0519-86626038
yuhh@hitechem.com CHINA 811 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29960 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 372 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58

View Lastest Price from 1,8-Dihydroxyanthraquinone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 chrysazin
117-10-2
US $100.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-09-26 1,8-Dihydroxyanthraquinone 117-10-2
117-10-2
US $12.50 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-08-04 1,8-Dihydroxyanthraquinone USP/EP/BP
117-10-2
US $1.10 / g 1g 0.999 100 Tons min Dideu Industries Group Limited

1,8-Dihydroxyanthraquinone Spectrum


117-10-2(1,8-Dihydroxyanthraquinone)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved