1,3-Benzodioxole
- CAS No.
- 274-09-9
- Chemical Name:
- 1,3-Benzodioxole
- Synonyms
- Benzo[d][1,3]dioxole;Benzodioxole;1,2-METHYLENEDIOXYBENZENE;1,2-Methylenedioxybenzene (MDB);1,3-BENZODIOXOL;1,3-DIOXAINDANE;BENZO[1,3]DIOXOLE;1,2-METHYLENDIOXYBENZENE;3,4-METHYLENEDIOXYBENZENE;MDB
- CBNumber:
- CB4180652
- Molecular Formula:
- C7H6O2
- Molecular Weight:
- 122.12
- MDL Number:
- MFCD00005818
- MOL File:
- 274-09-9.mol
- MSDS File:
- SDS
| Melting point | -18 °C |
|---|---|
| Boiling point | 172-173 °C(lit.) |
| Density | 1.064 g/mL at 25 °C(lit.) |
| vapor pressure | 12 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | 131 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 2g/l |
| form | Powder |
| color | Yellow to orange to brown |
| Water Solubility | 0.2 g/100 mL (25 ºC) |
| BRN | 115506 |
| InChIKey | FTNJQNQLEGKTGD-UHFFFAOYSA-N |
| LogP | 2.08 |
| CAS DataBase Reference | 274-09-9(CAS DataBase Reference) |
| FDA UNII | F0XLL582B8 |
| NIST Chemistry Reference | 1,3-Benzodioxole(274-09-9) |
| EPA Substance Registry System | 1,3-Benzodioxole (274-09-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/22-22-10-36/37/38-20/21/22-10/22 | |||||||||
| Safety Statements | 23-24/25-36/37/39-26-16-36 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DA5600000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29329970 | |||||||||
| NFPA 704 |
|
1,3-Benzodioxole price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 159166 | 1,3-Benzodioxole 99% | 274-09-9 | 50g | $63.9 | 2024-03-01 | Buy |
| TCI Chemical | M0658 | 1,2-Methylenedioxybenzene >99.0%(GC) | 274-09-9 | 25mL | $25 | 2024-03-01 | Buy |
| TCI Chemical | M0658 | 1,2-Methylenedioxybenzene >99.0%(GC) | 274-09-9 | 100mL | $64 | 2024-03-01 | Buy |
| Alfa Aesar | A14192 | 1,3-Benzodioxole, 99% | 274-09-9 | 50g | $36.65 | 2024-03-01 | Buy |
| Alfa Aesar | A14192 | 1,3-Benzodioxole, 99% | 274-09-9 | 250g | $163.65 | 2024-03-01 | Buy |
1,3-Benzodioxole Chemical Properties,Uses,Production
Description
1,3-Benzodioxole, widely found in plant products, has shown potent antioxidant and antibacterial activities. It has recently been reported that 1,3-benzodioxole derivatives possess cytotoxic activity against several human tumor cell lines, including human colon carcinoma cells and multidrug-resistant nasopharyngeal carcinoma cells. No cytotoxic effects were noticed at a concentration of 10-4 M.
Chemical Properties
clear colourless to light yellow liquid. Insoluble in acids.
Uses
1,3-Benzodioxole is useful in gemological stimulant detection. It is also used as a precursor for perfumes, photo initiators, agrochemicals and pharmaceuticals. 1,3-benzodimine is an intermediate for the synthesis of the drugs oxolinic acid, cinoxacin and miloxacin.
Production Methods
1,3-Benzodioxole is a colorless liquid. This compound is prepared by the reaction of catechol and dihalomethanes, for example, by use of concentrated aqueous alkaline solution in the presence of tetraalkylammonium or phosphonium salts, sometimes in the presence of alkyl iodides. 1,3-Benzodioxole is an important intermediate in organic synthesis, especially for the preparation of alkaloids.
Application
1,3-Benzodioxole belong to methylenedioxyphenyl (MDP) compounds that regulate cytochrome P 450-dependent drug oxidation, which is important in the process of eliminating drugs from the body. a hydrogen abstraction process can take place from the methylene-bridgea carbon of the benzodioxole compound and form a methylenedioxybenzene radical. It is therefore highly likely that 1,3-benzodioxole could serve as hydrogen donor for a CQ-based system initiating the photopolymerization of dental composite resin. In addition, 1,3-benzodioxole is an important organic intermediate (building block) to synthetize substituted methylenedioxybenzene products.
Definition
ChEBI: 1,3-benzodioxole is a benzodioxole consisting of a benzene ring substituted by a the methylenedioxy group.
General Description
Supersonic jet fluorescence spectra of 1,3-benzodioxole has been studied. The far-infrared spectrum of the vapour of 1,3-benzodioxole has been reported. The electronic absorption spectra and the laser-induced fluorescence spectra of supersonic-jet-cooled 1,3-benzodioxole molecules has been investigated.
1,3-Benzodioxole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Sinoda Biological Technology Co., Ltd | +8613401983379 | sales@njmcn.cn | CHINA | 74 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Nanjing Deda New Material Technology Ltd. | +8613223281135 | niki@njdeda.com | China | 73 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7377 | 58 |
| Shandong Juchuang Chemical Co., LTD | +86-18885615001 +86-18885615001 | admin@juchuangchem.com | China | 387 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
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View Lastest Price from 1,3-Benzodioxole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-19 | 1,3-Benzodioxole
274-09-9
|
US $5.00 / KG | 1KG | 99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2024-04-07 | 1,3-Benzodioxole
274-09-9
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. | |
 |
2024-03-29 | 1,3-Benzodioxole
274-09-9
|
US $10.00-30.00 / kg | 1kg | 99% | 100ton/ month | Nanjing Deda New Material Technology Ltd. |
-
- 1,3-Benzodioxole
274-09-9
- US $5.00 / KG
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 1,3-Benzodioxole
274-09-9
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
-
- 1,3-Benzodioxole
274-09-9
- US $10.00-30.00 / kg
- 99%
- Nanjing Deda New Material Technology Ltd.