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2-Butyl-4-chloro-5-formylimidazole

2-Butyl-4-chloro-5-formylimidazole Structure
2-Butyl-4-chloro-5-formylimidazole structure
CAS No.
83857-96-9
Chemical Name:
2-Butyl-4-chloro-5-formylimidazole
Synonyms
BCFI;2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE;2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBALDEHYDE;2-Butyl-4-chloroimidazole-5-carboxaldehyde;Losaint-A;ALSTint-A03;Losartan potassium-1;LOSARTAN INTERMEDIATES;Losartan EP IMpurity D;Losartan impurity D CRS
CBNumber:
CB4185349
Molecular Formula:
C8H11ClN2O
Molecular Weight:
186.64
MDL Number:
MFCD01934396
MOL File:
83857-96-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:57
Product description Number Pack Size Price
Losartan impurity D European Pharmacopoeia (EP) Reference Standard Y0001072 10 mg $167
2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE AldrichCPR T136964 1 unit $197
Losartan Related Compound A United States Pharmacopeia (USP) Reference Standard 1370473 20mg $1290
2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde 97% 559881 25g $169
2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde >98.0%(GC) B2914 25g $28
More product size
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2-Butyl-4-chloro-5-formylimidazole Properties

Melting point 97-100 °C(lit.)
Boiling point 384.1±22.0 °C(Predicted)
Density 1.240
vapor pressure 0.001Pa at 25℃
storage temp. Inert atmosphere,2-8°C
solubility soluble in methanol
form Powder to crystal
pka 8.87±0.10(Predicted)
color Pale Yellow to Brown
Water Solubility slightly soluble
InChI 1S/C8H11ClN2O/c1-2-3-4-7-10-6(5-12)8(9)11-7/h5H,2-4H2,1H3,(H,10,11)
InChIKey JLVIHQCWASNXCK-UHFFFAOYSA-N
SMILES CCCCc1nc(C=O)c(Cl)[nH]1
LogP 2.5 at 25℃ and pH7.1
Surface tension 58.3mN/m at 1.2g/L and 20℃
CAS DataBase Reference 83857-96-9(CAS DataBase Reference)
EWG's Food Scores 1-2
FDA UNII 7H170U0SWE
EPA Substance Registry System 2-Butyl-5-chloroimidazole-4-carbaldehyde (83857-96-9)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H317-H411
Precautionary statements  P261-P272-P273-P280-P302+P352-P333+P313
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xi,N
Risk Statements  43-51/53
Safety Statements  24-37-61
RIDADR  UN 3077 9/PG 3
WGK Germany  2
HazardClass  IRRITANT
PackingGroup  III
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Chronic 2
Skin Sens. 1A
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
0
2 0

2-Butyl-4-chloro-5-formylimidazole price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001072 Losartan impurity D European Pharmacopoeia (EP) Reference Standard 83857-96-9 10 mg $167 2026-04-30 Buy
Sigma-Aldrich T136964 2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE AldrichCPR 83857-96-9 1 unit $197 2026-04-30 Buy
Sigma-Aldrich 1370473 Losartan Related Compound A United States Pharmacopeia (USP) Reference Standard 83857-96-9 20mg $1290 2026-04-30 Buy
Sigma-Aldrich 559881 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde 97% 83857-96-9 25g $169 2023-01-07 Buy
TCI Chemical B2914 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde >98.0%(GC) 83857-96-9 25g $28 2026-04-30 Buy
Product number Packaging Price Buy
Y0001072 10 mg $167 Buy
T136964 1 unit $197 Buy
1370473 20mg $1290 Buy
559881 25g $169 Buy
B2914 25g $28 Buy

2-Butyl-4-chloro-5-formylimidazole Chemical Properties,Uses,Production

Description

2-Butyl-4-chloro-5-formylimidazole is an API intermediate used as an intermediate for the anti-hypertensive drug Chlosartan. It can be used in the chemical manufacture of many APIs and advanced intermediates. With the help of this chemical, a number of other chemicals can be manufactured that have further applications in industries such as Losartan manufacturing.

Chemical Properties

2-Butyl-4-chloro-5-formylimidazole is Yellow Solid

Uses

2-Butyl-4-chloro-5-formylimidazole is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists

Uses

2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde may be used in the preparation of the following symmetrical esters of dialkyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate:

  • dimethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • diethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • diisopropyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • diisobutyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • di-tert-butyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • bis(2-methoxyethyl) 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Application

2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A.

Synthesis Reference(s)

The Journal of Organic Chemistry, 64, p. 8084, 1999 DOI: 10.1021/jo9824910

Synthesis

2-Butyl-4-chloro-5-formylimidazole was synthesised as follows: Performing condensation reaction of pentamidine hydrochloride with glyoxal and controlling the pH value of the system in the range of 6.0-7.5; after the reaction terminates, arousing dehydration reaction of the compound of formula III, thereby obtaining 2-butyl-1H-imidazole-5(4H)-ketone; and finally, reacting 2-butyl-1H-imidazole-5(4H)-ketone with N,N-dimethylformamide in the presence of phosphorus oxychloride, thereby obtaining 2-butyl-4-chloro-5-formylimidazole.

storage

2-Butyl-4-chloro-5-formylimidazole is soluble in DMF, DMSO, Ethanol and Methanol.

2-Butyl-4-chloro-5-formylimidazole synthesis

79047-41-9
83857-96-9
Synthesis of 2-Butyl-4-chloro-5-formylimidazole from (2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL

2-Butyl-4-chloro-5-formylimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile (2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL EPROSARTAN N-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carboxyaldehyde 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde

2-Butyl-4-chloro-5-formylimidazole Suppliers

Global( 575)Suppliers
Supplier Tel Email Country ProdList Advantage
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23541 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5235 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21590 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29819 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 923 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2949 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
Supplier Advantage
ANHUI WITOP BIOTECH CO., LTD
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Jinan Finer Chemical Co., Ltd 		58
Xiamen AmoyChem Co., Ltd 		58
Shandong chuangyingchemical Co., Ltd. 		58

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View Lastest Price from 2-Butyl-4-chloro-5-formylimidazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Butyl-4-chloro-5-formylimidazole pictures 2026-05-04 2-Butyl-4-chloro-5-formylimidazole
83857-96-9
 0.99 RongNa Biotechnology Co.,Ltd
2-Butyl-4-chloro-5-formylimidazole pictures 2026-03-20 2-Butyl-4-chloro-5-formylimidazole
83857-96-9
 US $1.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Butyl-4-chloro-5-formylimidazole pictures 2025-12-01 2-Butyl-4-chloro-5-formylimidazole
83857-96-9
 US $0.00 / kg 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd

2-Butyl-4-chloro-5-formylimidazole Spectrum

2-Butyl-4-chloro-5-formylimidazole(83857-96-9)1HNMR2-Butyl-4-chloro-5-formylimidazole(83857-96-9)IR

83857-96-9(2-Butyl-4-chloro-5-formylimidazole)Related Search:

butyl rubber Tetrabutylammonium bromide 1-Vinylimidazole Butyl acetate n-Butyllithium
Methimazole Buprofezin Cyhalofop-butyl 2-Butoxyethanol 1-Bromobutane
Imidazole 1H-Imidazole-4-carbaldehyde Butyl acrylate tert-Butyldimethylsilyl chloride N-(n-butyl)thiophosphoric triamide
tert-Butanol Zolasartan Difluorochloromethane

1of4

2-BUTYL-4-CHLORO-5-IMIDAZOLECARBOXALDEHYDE (BCFI) 2-Butyl-5-formyl-4-chloroimidazole 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde 2-Butyl-5-chloro-4-formylimidazole 97% 2-BUTYL-5-CHLORO-1H-IMIDAGOLE- 2-N-BUTYL-4(5)-CHLORO-1H-IMIDAZOLE-5(4)-CARBOXALDEHYDE (INTERMEDIATE OF LOSARTAN) 2-n-Butyl-4-chloro-5-formylimidazloe 2-butyl-4-chloro-5-imidazolecarboxyaldehyde 2-n-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde 2-Butyl-4(5)-chloro-1H-imidazole-5(4)-carbaldehyde 2-Butyl-5-chloro-1H-imidazole-4-carbaldehyde ,99% 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde,2-Butyl-4-chloro-5-formylimidazole 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde 97% 2-(But-1-yl)-5-chloro-1H-imidazole-4-carboxaldehyde 97% 2-(But-1-yl)-5-chloro-4-formyl-1H-imidazole Ethyl(2S)-2-[(3S,8aS)-3-Methyl-1,4-dioxo-octahydropyrrolo[1,2-alpha]pyrazin-2-yl]-4-phenylbutanoate 2-n-Butyl-4(5)-Chloro-1H-IMidazole-5(4)-Carboxaldehyde (BCFI) 2-Butyl-4-chloro-5-formylimidazole,99% LOSARTAN INTERMEDIATES 2-n-butyl-4(5)-Chloro-1H-imdazole-5(4)-carboxaldehyde 2-Butyl-5-chloro-4-formylimidazole 2-Butyl-5-choloro-1H-imidazole-4-carbaldehyde 2-Butyl-4-chloro-5-imidazolecarboxaldehyde 2-Butyl-5-Chloro-1H-Imidagole-4-Carbaldehyde 2-Buty1-4(5)-Chloro-5(4)Imidazolecarboxaldehyde 2N-Butyl-4(5)-Chloro-1H-Imidazole-5(4)-Oarboxaldehyde 2-BUTYL-5-CHLOROIMIDAZOLE-4-CARBOXALDEHYDE 2-BUTYL-4-CHLORO-IMIDAZOLE-5-CARBALDEHYDE 2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBOXALDEHYDE 2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBOXALDEHYDE 2-BUTYL-4-CHLORO-5-FORMYLIMIDAZLOE 2-BUTYL-4-CHLORO-5-FORMYLIMIDAZOLE 2-BUTYL-4(5)-CHLORO-5(4)IMIDAZOLECARBOXALDEHYDE 2-N-BUTYL-5-CHLORO-4-FORMYL IMIDAZOLE 2-N-BUTYL-4(5)-CHLORO-1H-IMIDAZOLE-5(4)-CARBOXALDEHYDE 2-N-BUTYL-4-CHLORO-5-FORMYLIMIDAZOLE 2-N-BUTYL-4-CHLOROIMIDAZOLE-5-CARBOXALDEHYDE 2-Butyl-5-chloro-1H-imidazole carboxaldehyde 2-Butyl-4(5)-chloro-5(4)-imidazolecarboxyaldehyde Losartan EP IMpurity D 2- butyl-4-chloro -5-forMyl iMidazoles (2-n-Butyl-5-chloro-imidazole-4-yl)-carboxaldehyde 2-Butyl-4-chloro-5-formylimidazole (BCFI) 2-N-Butyl-4-chloro-5-Formyl Imidazole (BCFI) Losartan potassium-1 2-(But-1-yl)-5-chloro-1H-imidazole-4-carboxaldehyde Losartan potassium impurity A ALSTint-A03 Losaint-A Losartan Impurity D (EP) Losartan Impurity 4(Losartan EP Impurity D) Losartan Potassium EP Impurity D Losartan impurity D CRS 2-Butyl-4-chloro-1H-imidazole-5-car 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde > 1H-Imidazole-4-carboxaldehyde, 2-butyl-5-chloro- 2-Butyl-4-chloro-5-formylimidazole USP/EP/BP 2-Butyl-4-Chloro-5-Formyl-1H-Imidazole (BCFI)