Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Pictilisib

Pictilisib

Pictilisib Structure
Pictilisib structure
CAS No.
957054-30-7
Chemical Name:
Pictilisib
Synonyms
CS-23;RG7321;GDC-01;GNE0941;GDC-0941;GNE 0941;GNE-0941;Pictilisib;pictrelisib;GDC-0941, >=98%
CBNumber:
CB41872141
Molecular Formula:
C23H27N7O3S2
Molecular Weight:
513.64
MDL Number:
MFCD11616196
MOL File:
957054-30-7.mol
Last updated:2023-05-18 11:31:15
Request For Quotation

Pictilisib Properties

Melting point >200oC (dec.)
Density 1.53±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
pka 12.22±0.40(Predicted)
form White powder solid.
color White/off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
FDA UNII ICY00EMP8P

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
HS Code  29350090

Pictilisib price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 11600 GDC-0941 ≥98% 957054-30-7 10mg $134 2024-03-01 Buy
Cayman Chemical 11600 GDC-0941 ≥98% 957054-30-7 50mg $333 2024-03-01 Buy
Cayman Chemical 11600 GDC-0941 ≥98% 957054-30-7 100mg $531 2024-03-01 Buy
Biorbyt Ltd orb61040 GDC-0941, Free Base >99% pure 957054-30-7 100mg $493 2021-12-16 Buy
Biorbyt Ltd orb61040 GDC-0941, Free Base >99% pure 957054-30-7 50mg $343.4 2021-12-16 Buy
Product number Packaging Price Buy
11600 10mg $134 Buy
11600 50mg $333 Buy
11600 100mg $531 Buy
orb61040 100mg $493 Buy
orb61040 50mg $343.4 Buy

Pictilisib Chemical Properties,Uses,Production

Description

GDC-0941/Pictilisib (957054-30-7) is a potent and selective inhibitor of class I phosphatidylinositol-3-kinases (PI3K) with significant antitumor activity – IC50’s: PI3Kα = 3nM, PI3Kβ = 33 nM, PI3Kδ = 3 nM, PI3Kγ = 75 nM.1,2?? GDC-0941 is the chemical probe of choice for the pan-inhibition of class I PI3K’s.3?Currently in clinical trials.4

Uses

GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC-0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models. Potent PI3K inhibitor.

Uses

GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC -0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models.

Definition

ChEBI: A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring.

target

PI3Kα

References

1) Folkes?et al.?(2008),?The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine(GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer;? J.?Med. Chem.,?51?5522 2) Raynaud?et al. (2009),?Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinase: from PI-103 through PI-540, PI620 to the oral agent GDC-0941; Mol. Cancer Ther.,?8?1725 3) Knapp et al. (2013),?A public-private partnership to unlock the untargeted kinome; Nat. Chem. Biol.,?9?3 4) Sarker?et al. (2015),?First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors; Clin. Cancer Res.,?21?77

Pictilisib Preparation Products And Raw materials

Raw materials

Preparation Products

Pictilisib Suppliers

Global( 206)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9641 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Biochempartner 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Antai Fine Chemical Technology Co.,Limited 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from Pictilisib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)- pictures 2019-07-06 Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-
957054-30-7
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co

Pictilisib Spectrum

Pictilisib(957054-30-7)1HNMR

957054-30-7(Pictilisib)Related Search:

Motesanib DL-Malic acid Everolimus MK-2206 2HCl CAL-101
Trametinib PLX4032 BEZ235 (NVP-BEZ235, Dactolisib) 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE
NSC 23766 TETRAHYDROCHLORIDE NSC697923 MIF Antagonist, ISO-1 GSK-3β Inhibitor XVIII JNJ-10198409
Compound 23 ERK Inhibitor 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

1of4

Pictilisib Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)- GDC-0941 GDC-0941 free base 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine GDC-0941 bismesylate 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine 4-(2-(1H-Indazol-4-yl)-6-((4-(Methylsulfonyl)piperazin-1-yl)Methyl)thieno[3,2-d] 4-{6-[(4-Methanesulfonylpiperazin-1-yl)Methyl]-4-(Morpholin-4-yl)thieno[3,2-d]pyriMidin-2-yl}-1H-indazole 4-(2-(1H-indazol-4-yl)-6-((4-(Methylsulfonyl)piperazin-1-yl)Methyl)thieno[3,2-d]pyriMidin-4-yl)Morpholine 2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrim 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine RG7321 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine GDC-0941 GDC-0941 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine GDC-0941 (Pictilisib) pictrelisib GDC-0941;GDC 0941;GDC0941 2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]py GDC-0941, >=98% Pictilisib, 98%, a potent inhibitor of PI3Kα/δ GDC0941; GDC 0941; RG7321 GDC-0941;GDC 0941 CS-23 GDC-01 Pictilisib (GDC0941, RG7321, GNE0941)) 4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)me... PI 3-K Inhibitor XXI GDC-0941 GDC0941 GNE 0941 GNE0941 GNE-0941 957054-30-7 C23H27N7O3S2 An inhibitor of class I PI3 kinase (PI3K). Inhibitors Akt mTOR PI3K