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Boscalid

Fungicide Toxicity Mechanism Uses Preparation Patents
Boscalid
Boscalid structure
CAS No.
188425-85-6
Chemical Name:
Boscalid
Synonyms
BOSCALID;NICOBIFEN;boscalid solution;Boscalid 100mg [188425-85-6];FREE SAMPLE NCV BOSCALID TECHNICAL;2-Chloro-N-(4'-chloro-[1,1'-biphenyl]-2-yl);2-CHLORO-N-(4'-CHLORO-2-BIPHENYLYL)NICOTINAMIDE;2-CHLORO-N-(4'-CHLOROBIPHENYL-2-YL)-NICOTINAMIDE;2-Chloro-N-(4'-chloro-[1,1'-biphenyl]-2-yl)nicotinaMide;2-Chloro-N-(4μ-chloro-2-biphenylyl)nicotinamide, Nicobifen
CBNumber:
CB4201139
Molecular Formula:
C18H12Cl2N2O
Formula Weight:
343.21
MOL File:
188425-85-6.mol

Boscalid Properties

Melting point:
142.8-143.8°.
Density 
1.381
Flash point:
4 °C
storage temp. 
0-6°C
form 
neat &_& solid
Merck 
14,1352
EPA Substance Registry System
3-Pyridinecarboxamide, 2-chloro-N-(4'-chloro[ 1,1'-biphenyl]-2-yl)- (188425-85-6)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS09
Hazard statements  H411
Precautionary statements  P273-P391-P501
Hazard Codes  F,Xn,N
Risk Statements  11-38-48/20-63-65-67-51/53
Safety Statements  36/37-62-61
RIDADR  UN1294 3/PG 2
WGK Germany  2
RTECS  US4587550
HazardClass  9
PackingGroup  III
Toxicity LD50 in rats (mg/kg): >5000 orally; >2000 dermally (U.S. EPA)

Boscalid price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 33875 Boscalid PESTANAL 188425-85-6 100mg-r $66.9 2018-11-20 Buy
TCI Chemical B4038 Boscalid >98.0%(HPLC)(N) 188425-85-6 1g $360 2018-11-22 Buy
TCI Chemical B4038 Boscalid >98.0%(HPLC)(N) 188425-85-6 100mg $61 2018-11-22 Buy
Cayman Chemical 24135 Boscalid ≥95% 188425-85-6 50mg $25 2018-11-19 Buy
Cayman Chemical 24135 Boscalid ≥95% 188425-85-6 100mg $48 2018-11-19 Buy

Boscalid Chemical Properties,Uses,Production

Fungicide

Boscalid is a kind of nicotinamide germicide first successfully developed by BASF of Germany. It has a broad spectrum of bactericidal activity and has a preventive effect, being active against almost all types of fungal diseases. It has excellent effects on the control of powdery mildew, gray mold, root rot disease, sclerotinia and various kinds of rot diseases and is not easy to produce cross-resistance. It is also effective against the resistant bacteria to other agents. It is mainly used for the prevention and control of diseases associated with rape, grapes, fruit trees, vegetables and field crops. The results have showed that Boscalid had a significant effect on the treatment of Sclerotinia sclerotiorum with both the disease incidence control effect and the disease control index being higher than 80%, which was better than any of the other agents currently popularized. It has a significantly higher control efficacy than carbendazim. Apply 50% boscalid water solution dispersible granules to control rape sclerotia disease with a dose of 24 to 36 grams per acre medication per general year. In severe years, apply 36 to 48 grams per acre for medication.

Toxicity

(1) Mammalian toxicity: rat acute oral LD50> 5,000 mg/kg; Rat acute pertacuneous LD50 > 2,000 mg/kg, being non-irritating to skin and eyes of rabbits without sensitization to guinea pig skin. Rats inhaled LC50 (4 h)> 6.7 mg/L. NOEL: Rats, approximately 5 mg/kg (b. w.); Chronic NOAEL: 21.8 mg/kg (b. w.). [2003]; ADI/RfD (JMPR) 0.04 mg/kg (b.w.) [2006]; (EC) 0.04 mg/kg (b.w.) [2008]; cRfD 0.218 mg/kg (b.w.) [2003], (FSC) 0.044 mg/kg (b.w.) [2006]; other: no mutagenicity (Ames test, mouse), teratogenicity (rat, rabbit) and carcinogenic effects (dog, rat, mice); no adverse effects on reproduction (rat).
(2) Ecotoxicity: Birds: Quail LD50> 2,000 mg/kg (b.w.). Fish: Rainbow trout LC50 (96 h) was 2.7 mg/L. Daphnia: EC50 (48 h) was 5.33 mg/L. The algae: Pseudokirchneriella subcapitata ErC50 (96 h) was 3.75 mg/L. Other aquatic organisms: Chironomus riparius NOEC 2.0 mg/L. Bee: NOEC (oral) is 166 μg /bee, (contact) is 200 μg/bee. Earthworm: Eisenia foetida LC50> 1,000 mg/kg (dry soil).
(3) Environmental toxicity: animal: biphenyl ring is first subject to hydroxylation, followed by glucosylation and sulfation reaction. Boscalid is rapidly and extensively subject to metabolism in the body and excreted rapidly through the feces. Plants: biphenyl and pyridine ring are subject to hydroxylation and further ring-opening reaction. However, the parent compound, which has not been structurally altered, remains to be a major part of the residue. Soil/environment: it has moderate degradation action in the soil with the soil DT50 being 108 d ~> 1 a (laboratory, aerobic conditions, 20 ℃); the DT50 of the field is about 28d~200d. It has a excellent degradation property in natural water/sediment systems.

Mechanism

Boscalid is a kind of mitochondrion respiration inhibitor, being the inhibitor of the succinate dehydrogenase (SDHI) that acts by inhibiting succinate coenzyme Q reductase (also known as complex II) on the mitochondrial electron transport chain, with its mechanism of action being similar as that of other kinds of amide and benzamide fungicides. It has effects on the entire growth period of the pathogen, especially having a strong inhibitory effect against the spore germination. It also has excellent prophylactic effects and excellent intra-leaf permeability.
Boscalid is a foliar application germicide, which can penetrate vertically and be transmitted to the top of the plant leaves. It has excellent preventive effect and has certain therapeutic effect. It can also inhibit the spore germination, germ tube elongation and attachment formation, and is effective in all other growth stages of the fungus, exhibiting excellent resistance to rain erosion and persistence.

Uses

Boscalid is a broad-spectrum, systemic fungicide, which can effectively control the diseases that are resistant to sterol inhibitors, bisimides, benzimidazoles, benzopyrimidines, phenyl amides and methoxy acrylic esters germicide. This product can be transported to the top of the plant through the xylem to the tip and leaf margin; it also has a vertical penetration effect, being able to be transmitted through the leaf tissue, to the back of the leaf; however, the product has a very small redistribution action in the vapor phase. Boscalid is mainly through spraying through stem and leaf at a dosage of 100~1,200 g a.i. /hm2.
Boscalid can be used for the prevention and treatment of the powdery mildew (Monilinia spp), leaf spot (Mycosphaerella spp) as well as diseases caused by Alternaria spp., Alternaria spp., Botrytis cinerea, Botrytis cinerea, (Botrytis spp), Sclerotinia sclerotiorum (Sclerotinia spp) that have been found in grape, lawn, fruit trees, and ornamental plant. It can also be used in complex formulations for grain, grapes, peanuts and potatoes and other tillage crops.
Boscalid also owns single-dosage product such as Cantus, to be used in pear, grape and post-harvest kiwifruit to control gray mold with the usage amount of 1~1.2kg/hm2. It can be used in different growth stages of grape with however, spraying before the grapes form cluster yielding the best efficacy. It also has a wide range of complex products. For example, Bellis (25.2% piperacillin + 12.8% pyrizole) is a broad-spectrum fungicide, being able to be registered for watermelon and pear. The recommendation dosage for its water dispersible granules is 0.6-1.6 kg/hm2 for the control of many diseases, including anthrax, Botrytis cinerea, Monilinia spp and black spot disease. This product has been developed in Latin America and Italy.
Another example is that Signum (26.7% piperacillin + 6.7% pyrazole) has been registered for apricot, horticultural products and lettuce for the control of black spot, gray mold and sclerotinia. This product is also water dispersible granules with prevention effect. Furthermore, the germicide for fruit trees, Naria (Pyraclostrobin + boscalid) has been approved for registration in Japan in 2006 and listed in 2007. Naria is widely used in the control of many diseases in apple, Japanese pear, cherry and peach. It is especially suitable for the prevention of some refractory diseases in summer such as: leaf spot, black spot, scab, anthrax, ring rot and powdery mildew.

Preparation

1.  Take o-chloronitrobenzene as raw material, first have it react with chlorobenzene boronic acid to undergo Suziki reaction, followed by reduction, and finally condensation with 2-chloronicotinyl chloride to obtain Boscalid crude product.
2. Take o-iodine aniline as raw material, first have reaction with 2-chloronicotinyl chloride, followed by Suzuki reaction with chlorobenzene boric acid to obtain the finished product.

Patents

On November 7, 2012, the patent on the European patent expired.
On November 9, 2012, its patents in the United States expire.
November 9, 2012, the administrative protection period of the compound in China expires.
In 2003, Boscalid was registered in the United States and obtained a 10-year registration of data protection.
In August 1, 2008, Boscalid was listed in the Appendix 1 of the EU pesticide registration directive (91/414) with its registration information being protected to until July 31, 2018.
The patent and administrative protection in Europe and the United States and China will soon expire, but the EU data protein is far lagged behind from its patent protection. Non-patented products manufacturers, if needs to enter the European and American markets, must prepare a complete set of registration information, or consult the data owner. Alternatively, they can enter into the markets until the information protein is expired. However, boscalid will soon become a focus of those non-patented manufactures in China, which will lead to the escalation of the Chinese market completion of boscalid.

Chemical Properties

Light Beige Solid

Uses

Boscalid is a fungicide belonging to the class of carboxamides. Boscalid acts by inhibiting spore germination, germ tube elongation and is also effective on all other stages of fungal development. Bos calid is used in the agriculture to protect crops from gray mold, powdery mildew and other fungus.

Uses

Fungicide.

Definition

ChEBI: A pyridinecarboxamide obtained by formal condensation of the carboxy group of 2-chloronicotinic acid with the amino group of 4'-chlorobiphenyl-2-amine. A fungicide active against a broad range of fungal pathogens including Botrytis spp., <ital Alternaria spp. and Sclerotinia spp. for use on a wide range of crops including fruit, vegetables and ornamentals.

Boscalid Preparation Products And Raw materials

Raw materials

Preparation Products


Boscalid Suppliers

Global( 111)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21707 58
Hangzhou Bayee Chemical Co., Ltd.
0086-571-86990109; 0086-18605816692
0086-571-85775919 rachelhoo@bayeechem.com China 98 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29955 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8922 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 911 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6370 58

View Lastest Price from Boscalid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-26 Boscalid
188425-85-6
US $1.00 / g 1g 99% 200 Ton/Tons per Month Cangzhou Wanyou New Material Technology Co.,Ltd
2018-08-12 Boscalid
188425-85-6
US $1.00 / KG 1KG 99% 1000KG career henan chemical co

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