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Latanoprost acid

Latanoprost acid Structure
Latanoprost acid structure
CAS No.
41639-83-2
Chemical Name:
Latanoprost acid
Synonyms
(5Z)-;LAT-FA;LT-Acid;PHXA 85;LATANOPROST ACID;latanoprostfreeaci;LATANOPROST (FREE ACID);LATANOPROSTACID;PHXA 85;Latanoprost Impurity 23;LT-ACID(LATANOPROST ACID)
CBNumber:
CB4208385
Molecular Formula:
C23H34O5
Molecular Weight:
390.51
MDL Number:
MFCD08056084
MOL File:
41639-83-2.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:18
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Latanoprost acid Properties

Boiling point 609.1±50.0 °C(Predicted)
Density 1.159±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: freely soluble
pka 4.76±0.10(Predicted)
form Oil
color pale yellow, oil
Stability Hygroscopic
FDA UNII EJ85341990

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
WGK Germany  3
HS Code  2937500000
NFPA 704
3
2 0

Latanoprost acid price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L1292 Latanoprost acid ≥98% (HPLC) 41639-83-2 1mg $188 2024-03-01 Buy
Sigma-Aldrich Y0002205 Latanoprost impurity H CRS European Pharmacopoeia (EP) Reference Standard 41639-83-2 Y0002205 $1970 2024-03-01 Buy
Sigma-Aldrich 1357533 Latanoprost Related Compound E United States Pharmacopeia (USP) Reference Standard 41639-83-2 25mg $1850 2024-03-01 Buy
Cayman Chemical 16811 Latanoprost (free acid) ≥98% 41639-83-2 1mg $68 2024-03-01 Buy
Cayman Chemical 16811 Latanoprost (free acid) ≥98% 41639-83-2 5mg $302 2024-03-01 Buy
Product number Packaging Price Buy
L1292 1mg $188 Buy
Y0002205 Y0002205 $1970 Buy
1357533 25mg $1850 Buy
16811 1mg $68 Buy
16811 5mg $302 Buy

Latanoprost acid Chemical Properties,Uses,Production

Description

Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.

Chemical Properties

Pale Yellow Oil

Uses

A metabolite of Latanoprost. Potent, selective FP prostanoid receptor agonist. F-series Prostaglandin analog. 200 times as potent as isopropyl ester form. Latanoprost USP Related Compound E.

Definition

ChEBI: A prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone f rmal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension.

Biochem/physiol Actions

Potent, selective FP prostanoid receptor agonist, F-series prostaglandin analog. 200 times as potent as isopropyl ester form.

Latanoprost acid Preparation Products And Raw materials

Raw materials

Preparation Products

Latanoprost

Latanoprost acid Suppliers

Global( 119)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9923 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12382 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
Standardpharm Co. Ltd. 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
AFINE CHEMICALS LIMITED 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
sgtlifesciences pvt ltd 		58

View Lastest Price from Latanoprost acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Latanoprost acid pictures 2020-02-18 Latanoprost acid
41639-83-2
 US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co

41639-83-2(Latanoprost acid)Related Search:

Latanoprost Epoxide (Mixture of isoMers) Latanoprost Tris(triethylsilyl) Ether NCX 116 15-KETO LATANOPROST (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid
15(S)-Latanoprost Latanoprost Lactone Diol trans Latanoprost CHLOROPHOSPHONAZO III Prostaglandin E2
Latanoprost Citric acid Ethyl 2-(Chlorosulfonyl)acetate Prostaglandin E1 Folic acid
Ascoric Acid Latanoprost Impurity 1 Latanoprost Impurity (Diphenylphosphine Isopropyl Ester)

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LATANOPROST (FREE ACID) LAT-FA 17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA (5Z,9ALPHA,11ALPHA,15R)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5-EN-1-OIC ACID 9ALPHA, 11ALPHA, 15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID PHXA 85 PhXA 85, (5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid Latanoprost acid,(5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid, PhXA 85 LT-ACID(LATANOPROST ACID) LT-Acid (5z,9α,11α,15r)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid LATANOPROST ACID (5Z)- Latanoprost Related CoMpound E Latanoprost Related Compound E (25 mg) ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid) (Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid LT-Acid(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid LATANOPROSTACID;PHXA 85 (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid Latanoprost Impurity 8（Latanoprost Acid） Latanoprost Acid/(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, (5Z)- latanoprostfreeaci Latanoprost Related Compound E ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl (1357533) Latanoprost Impurity 23 Latanoprost EP Impurity H Latanoprost EP Impurity H (Latanoprost USP Related Compound E) Latanoprost Acid / Latanoprost Related Compound-E 41639-83-2 7130209-82-4 C26H40O5 C23H35O5 Aromatics, Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals Aromatics Chiral Reagents Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals