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Ranolazine-d5

CAS No.
1092804-87-9
Chemical Name:
Ranolazine-d5
Synonyms
Ranolazine-d5;N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl-1,1,2,3,3-d5]-1-piperazineacetamide
CBNumber:
CB42104247
Molecular Formula:
C24H28D5N3O4
Molecular Weight:
432.56732889
MDL Number:
MOL File:
1092804-87-9.mol
Last updated:2023-05-21 10:59:17

Ranolazine-d5 Properties

storage temp. Store at -20°C
solubility Dichloromethane: Soluble; Methanol: Soluble
form A solid

Ranolazine-d5 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25424 Ranolazine-d5 ≥99% deuterated forms (d1-d5) 1092804-87-9 500μg $230 2024-03-01 Buy
Cayman Chemical 25424 Ranolazine-d5 ≥99% deuterated forms (d1-d5) 1092804-87-9 1mg $434 2024-03-01 Buy
AK Scientific 2996DC N-(2,6-Dimethylphenyl)-2-[4-[1,1,2,3,3-pentadeuterio-2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide 1092804-87-9 1mg $559 2021-12-16 Buy
American Custom Chemicals Corporation RDL0007103 RANOLAZINE-D5 95.00% 1092804-87-9 1MG $739.2 2021-12-16 Buy
American Custom Chemicals Corporation RDL0007103 RANOLAZINE-D5 95.00% 1092804-87-9 10MG $1871.1 2021-12-16 Buy
Product number Packaging Price Buy
25424 500μg $230 Buy
25424 1mg $434 Buy
2996DC 1mg $559 Buy
RDL0007103 1MG $739.2 Buy
RDL0007103 10MG $1871.1 Buy

Ranolazine-d5 Chemical Properties,Uses,Production

Description

Ranolazine-d5 is intended for use as an internal standard for the quantification of ranolazine by GC- or LC-MS. Ranolazine is a piperazine derivative with cardioprotective activity.1,2,3,4 It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively).1,2 Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively).2 In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits.3 Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .4

References

1. Shryock, J.C., and Belardinelli, L. Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium Br. J. Pharmacol. 153(6),1128-1132(2008).
2. Verrier, R.L., Kumar, K., Nieminen, T., et al. Mechanisms of ranolazine’s dual protection against atrial and ventricular fibrillation Europace 15(3),317-324(2013).
3. Wang, W.Q., Robertson, C., Dhalla, A.K., et al. Antitorsadogenic effects of (±)-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits J. Pharmacol. Exp. Ther. 325(3),875-881(2008).
4. Tocchetti, C.G., Carpi, A., Coppola, C., et al. Ranolazine protects from doxorubicin-induced oxidative stress and cardiac dysfunction Eur. J. Heart Fail. 16(4),358-366(2014).

Ranolazine-d5 Preparation Products And Raw materials

Raw materials

Preparation Products

Ranolazine-d5 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 rose.shi@synzest.com China 9287 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Nanjing Shizhou Biology Technology Co.,Ltd 17301488900 judy.xia@synzest.com China 13698 58

1092804-87-9(Ranolazine-d5)Related Search:

Ranolazine-d5 N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl-1,1,2,3,3-d5]-1-piperazineacetamide 1092804-87-9 C24H28N3O4D5