5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT
![5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT Structure](CAS/GIF/1949-20-8.gif)
- CAS No.
- 1949-20-8
- Chemical Name:
- 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT
- Synonyms
- OXOLAMINE CITRATE;AF-438 citrate;OxolaminCitrate;SKF-9976 citrate;CITRATO OXOLAMINA;CITRATE OXOLAMINE;Oxolamine Citric Acid;OXOLAMINE CITRATE SALT;Oxolamine citrate (SKF-9976;oxolamine dihydrogen citrate
- CBNumber:
- CB4212634
- Molecular Formula:
- C20H27N3O8
- Molecular Weight:
- 437.44
- MDL Number:
- MFCD00083457
- MOL File:
- 1949-20-8.mol
| Melting point | 141-142 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| color | Crystals. Sltly sol in water and alc |
| FDA UNII | K5X4XBR694 |
5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O2256 | Oxolamine citrate salt | 1949-20-8 | 25g | $83.3 | 2024-03-01 | Buy |
| Usbiological | 165764 | Oxolamine Citrate | 1949-20-8 | 1g | $319 | 2021-12-16 | Buy |
| TRC | O857450 | OxolamineCitrate | 1949-20-8 | 25g | $75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008452 | OXOLAMINE CITRATE SALT 95.00% | 1949-20-8 | 10MG | $400.02 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008452 | OXOLAMINE CITRATE SALT 95.00% | 1949-20-8 | 25G | $469.6 | 2021-12-16 | Buy |
5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT Chemical Properties,Uses,Production
Originator
Bredon,Organon
Uses
Oxolamine Citrate, is a antiinflammatory drug used as a cough suppressant.
Manufacturing Process
18.7 g 3-chloro-propionyl chloride in 50 ml of dry ether was added dropwise with stirring to the cooled with ice solution 40 g of N-hydroxybenzamidine in 450 ml dry ester. A dense precipitate had fallen. The mixture was stirred 0.5 hour at room temperature and then was filtered off. The precipitate was thoroughly washed with water for a removal hydrochloride of starting Nhydroxybenzamidine whereas N-(amino)phenylmethylene-3-Cl-propionamide didnt solve. It was dried in vacuum over P2O5. Yield of clean product 94% from theoretical. MP: 98°-99°C. The solution of 9.2 g diethyl amine in 50 ml dry benzene was added dropwise to a suspension of above prepared N(amino)phenylmethylene-3-Cl-propionamide in dry benzene with stirring and cooling.
The mixture was warmed and stirred else 2 hours after adding. Then it was cooled, washed two times with water and dried over CaCl2. Then the solvent was removed. The residue was distilled in vacuum. Diethyl-[2-(3phenyl[1,2,4]oxadiasol-5)ethyl]amine (oxolamine) had BP: 127°C/0.4 mm. Yield 10.5 g.
Therapeutic Function
Antitussive, Antiinflammatory
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx. See also AMINES and other oxolamhe entries
5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15746 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |