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17-Methyltestosterone

Overview Indication and administration Mode of action Adverse reactions Warning and precaution References
17-Methyltestosterone
17-Methyltestosterone structure
CAS No.
58-18-4
Chemical Name:
17-Methyltestosterone
Synonyms
Nu-man;ru24400;Syndren;Testora;Hormale;Malogen;Metrone;Oraviron;NSC-9701;Oreton-M
CBNumber:
CB4213510
Molecular Formula:
C20H30O2
Formula Weight:
302.45
MOL File:
58-18-4.mol

17-Methyltestosterone Properties

Melting point:
162-168 °C(lit.)
Boiling point:
383.47°C (rough estimate)
alpha 
79 º (c=1, alcohol)
Density 
1.0434 (rough estimate)
refractive index 
1.4800 (estimate)
Flash point:
5 °C
storage temp. 
2-8°C
solubility 
H2O: ≤0.5 mg/mL
form 
solid (photosensitive)
color 
white
Merck 
13,6148
BRN 
2057425
InChIKey
GCKMFJBGXUYNAG-HLXURNFRSA-N
CAS DataBase Reference
58-18-4(CAS DataBase Reference)
NIST Chemistry Reference
17(Alpha)-methyl-delta4-androsten-17-(beta)-ol-3-one(58-18-4)
EPA Substance Registry System
Androst-4-en-3-one, 17-hydroxy-17-methyl-, (17.beta.)-(58-18-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08,GHS02,GHS07
Signal word  Danger
Hazard statements  H350-H361-H225-H332-H360FD
Precautionary statements  P201-P280-P308+P313-P210-P370+P378-P403+P235-P281
Hazard Codes  T,Xn,F,Xi
Risk Statements  45-63-22-20-19-11-61-60-36/37/38-38-10
Safety Statements  53-36/37-45-24/25-22
RIDADR  3249
WGK Germany  3
RTECS  BV8400000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29372900

17-Methyltestosterone price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M7252 17α-Methyltestosterone solid (photosensitive) 58-18-4 1g $56.6 2018-11-20 Buy
Sigma-Aldrich 1438001 Methyltestosterone United States Pharmacopeia (USP) Reference Standard 58-18-4 250mg $467.95 2018-11-20 Buy
Cayman Chemical 24080 17α-Methyltestosterone ≥98% 58-18-4 1mg $30 2018-11-19 Buy
Cayman Chemical 24080 17α-Methyltestosterone ≥98% 58-18-4 5mg $75 2018-11-19 Buy
Sigma-Aldrich M7252 17α-Methyltestosterone solid (photosensitive) 58-18-4 5g $83.9 2018-11-20 Buy

17-Methyltestosterone Chemical Properties,Uses,Production

Overview

17-Methyltestosterone, a synthetic derivative of testosterone, is an androgen and anabolic steroid (AAS) medication. It is mainly used in the treatment of low testosterone levels in men, delayed puberty in boys, at low doses as a component of menopausal hormone therapy for menopausal symptoms like hot flashes, osteoporosis, and low sexual desire in women, and to treat breast cancer in women (1-3). It appears as white or creamy white crystals or powder, which is soluble in various organic sol vents but is practically insoluble in water. It should be subject to oral administration.
Methyltestosterone was first discovered in 1935 and was introduced for medical use in 1936. It was synthesized shortly after the discovery of testosterone, being one of the first synthetic AAS drug. 17-Methyltestosterone, beyond its medical function, can also be used to improve physique and performance, although it is not as commonly used as other AAS for such purposes due to its androgenic effects, estrogenic effects, and risk of liver damage. The drug is a controlled substance in many countries and so non-medical use is generally illicit.

Indication and administration

It has been used in the treatment of various symptoms such as hypogonadism, cryptorchidism, delayed puberty, and erectile dysfunction in males, and in low doses to treat menopausal symptoms (specifically for osteoporosis, hot flashes, and to increase libido and energy), postpartum breast pain and engorgement.
In US, 17-Methyltestosterone is an anabolic steroid hormone that majorly used to treat men with a testosterone deficiency, hypogonadism and delayed puberty. Hypogonadism include both primary type and hypogonadotropic type: the former one can be caused by cryptorchidism, bilateral torsions, orchitis, vanishing testis syndrome; or orchidectomy. The later one includes idiopathic gonadotropin or LHRH deficiency, or pituitary hypothalamic injury from tumors, trauma, or radiation. It is also used in women to treat breast cancer, breast pain, swelling due to pregnancy, and with the addition of estrogen it can treat symptoms of menopause. It has also been used in combination with esterified estrogens for the treatment of moderate to severe vasomotor symptoms associated with menopause in females.
17-Methyltestosterone is administered orally. The suggested dosage varies depending on the age, sex, and diagnosis of the individual patient. Dosage is adjusted according to the patient's response and the appearance of adverse reactions. Replacement therapy in androgen-deficient males usually demands 10 to 50 mg of 17-Methyltestosterone daily. However, the chronological and skeletal ages must be taken into consideration both in determining the initial dose and in adjusting the dose. Doses used in the treatment of the delayed puberty generally are in the lower range of that given above, and for a limited duration, for example 4 to 6 months. For the treatment of women breast cancer, the dosage of 17-Methyltestosterone in females is from 50-200 mg daily.

Mode of action

17-Methyltestosterone take effects through two main mechanisms: activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors.
17-Methyltestosterone can enter into the target tissue cells, binding to the androgen receptor, or being reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly, yielding a even stronger androgenic potency. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA, which is called hormone response elements (HREs). This process regulates the transcriptional activity of various genes, further producing the androgen effects.

Adverse reactions

17-methyltestosterone can cause various kinds of adverse reactions. Common side effects include increased facial/body hair growth, scalp hair loss, increased aggressiveness, skin, acne, seborrhea, and sex drive and spontaneous erections. There are also some kinds of estrogenic side effects such as breast tenderness, gynecomastia, fluid retention, and edema. Men can suffer hypogonadism, testicular atrophy, and reversible infertility. Women can sometimes suffer partially irreversible virilization including clitoromegaly, breast atrophy, voice deepening, hirsutism and muscle hypertrophy, as well as menstrual disturbances and reversible infertility.
17-methyltestosterone may also cause hepatotoxicity including elevated liver enzymes, cholestatic jaundice, peliosis hepatis, hepatomas, and hepatocellular carcinoma. It can also have adverse effect on the cardiovascular system such as causing erythropoiesis, increase hematocrit levels or even polycythemia, further leading to even thrombic events such as embolism and stroke. Finally, long-term treatment increase the risk of cancer. Some extreme cases also include hypomania/mania, depression, delusions, suicidality and psychosis.

Warning and precaution

People of the following cases should not use it: allergy; prostate cancer; male breast cancer, pregnant.
People with liver or kidney disease, an enlarged prostate, heart disease, congestive heart failure should use with caution.

References

 

Chemical Properties

white to slightly yellowish-white crystalline

Uses

Androgen. It has been used as an androgenic agent. Controlled substance (anabolic steroid).

Definition

ChEBI: A 17beta-hydroxy steroid that is testosterone bearing a methyl group at the 17alpha position.

brand name

Android (Valeant);Metandren (Novartis); Oreton (Schering); Testred (Valeant); Virilon (Star).

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Human teratogenic effects by ingestion: developmental abnormalities of the urogenital system. Experimental teratogenic and reproductive effects. Human systemic effects: cholestatic jaundce, weight loss or decreased weight gain. Questionable human carcinogen producing liver tumors. A synthetic androgenic steroid. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

This anabolic steroid is crystallised from hexane or hexane/*benzene. It has E1cm 1% 495-530 at 241nm (EtOH). The colour reaction with 2,4-dinitrophenyl hydrazine is used for assaying it. [Gornall & Macdonald J Biol Chem 201 279 1953.] In another colour reaction the sterone (1mg) in acetic acid (0.2ml) + 88% H3PO4 (2mL) is allowed to stand for 1hour when it becames fluorescent. After 1hour it is diluted with acetic acid (~3mL) and provides a strong yellow fluorescence with the intensity of 50-100 times that of estrone. [Stuart & Stuckey J Pharm Pharmacol 1 130 1949, Openauer Rec Trav Chim Pays-Bas 56 137 137, Beilstein 8 IV 1010.]

17-Methyltestosterone Preparation Products And Raw materials

Raw materials

Preparation Products


17-Methyltestosterone Suppliers

Global( 267)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21714 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 272 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
Hebei Minshang Biotechnology Co., Ltd
+86-13582176207
cathy@hbminshang.com CHINA 272 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1017 58
Zhenfei Industrial Co. Ltd.
+86 15318988277
sales@zhenfeichem.com CHINA 75 58

View Lastest Price from 17-Methyltestosterone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-10-15 Methyltestosterone
58-18-4
US $0.00 / KG 1g 99.98% 1 ton Hebei shuoxi biotechnology co. LTD
2019-09-11 17-Methyltestosterone
58-18-4
US $1.00 / ASSAYS 1ASSAYS 0.99 1000kg Shanghai Longyu Biotechnology Co., Ltd.
2019-07-05 Methyltestosteroness
58-18-4
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

17-Methyltestosterone Spectrum


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