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Cimetidine

Description Medical Uses Information on Dosing Mechanism of Action Interactions Side Effects Warnings References
Cimetidine
Cimetidine
CAS No.
51481-61-9
Chemical Name:
Cimetidine
Synonyms
Ulhys;Cimal;Notul;Acinil;Peptol;Tratul;Aciloc;Biomag;Ulcomet;venopex
CBNumber:
CB4229414
Molecular Formula:
C10H16N6S
Formula Weight:
252.34
MOL File:
51481-61-9.mol

Cimetidine Properties

Melting point:
139-144°C
Density 
1.2583 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
2-8°C
solubility 
Slightly soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute mineral acids.
form 
neat
pka
pKa 6.80 (Uncertain)
Water Solubility 
0.5 g/100 mL at 20 ºC
Merck 
14,2279
CAS DataBase Reference
51481-61-9(CAS DataBase Reference)
NIST Chemistry Reference
Cimetidine(51481-61-9)
EPA Substance Registry System
Guanidine, N-cyano-N'-methyl-N''-[ 2-[[(5-methyl-1H-imidazol- 4-yl)methyl]thio]ethyl]-(51481-61-9)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,Xn
Risk Statements  60-42/43-36/37/38-20/22
Safety Statements  53-26-36/37/39-45-36-22
WGK Germany  3
RTECS  MF0035500
HS Code  29339900
Hazardous Substances Data 51481-61-9(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): 2600, 5000 orally; 150, 106 i.v.; 470, 650 i.p. (Brimblecombe)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

Cimetidine price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C4522 Cimetidine 51481-61-9 5g $71.1 2018-11-13 Buy
Sigma-Aldrich 1134062 Cimetidine United States Pharmacopeia (USP) Reference Standard 51481-61-9 200mg $348 2018-11-13 Buy
TCI Chemical C1252 Cimetidine >99.0%(HPLC)(T) 51481-61-9 25g $158 2018-11-22 Buy
Alfa Aesar J62825 Cimetidine, 98+% 51481-61-9 10g $95.9 2018-11-13 Buy
Alfa Aesar J62825 Cimetidine, 98+% 51481-61-9 5g $66.9 2018-11-13 Buy

Cimetidine Chemical Properties,Uses,Production

Description

Cimetidine (brand name: Tagamet) is a kind of histamine H2 receptor antagonist being capable of inhibiting the production of stomach acid, which reduces the gastric volume and acidity. It is mainly used for the treatment of heartburn and peptic ulcers. There are also evidences that it can be used for the treatment of common warts, chronic calcific tendinitis of the shoulder, and even colorectal cancer. It is capable of not only inhibiting the gastric acid secretion, as well as pepsin and gastrins output, but also inhibiting the activity of cytochrome P450. It reduces the gastric acid secretion through binding to the H2 receptor locating on the basolateral membrane of the gastric parietal cell, and further blocking histamine effect.

Medical Uses

Cimetidine is a medical drug that inhibits acid production by specific cells in the human stomach and can be dispensed orally or intravenously. Cimetidine is an effective remedy for heartburn that is resultant of a sour stomach or acid indigestion. The drug also reliefs heart burn that is associated with the consumption of certain beverages and foods.
Cimetidine is used in the treatment of ulcers and the prevention of certain conditions that may influence the stomach to produce excess amounts of acid. The drug is also used for the treatment of gastrointestinal reflux disease (GERD), a condition when stomach acid accumulates and oozes into the esophagus resulting in heartburn.
Some of the conditions associated with overproduction of acid by the stomach may include systemic mastocytosis, Zollinger-Ellison syndrome, and multiple endocrine adenomas. Cimetidine is an effective remedy for these conditions as it decreases the amount of acid produced by the stomach.

Information on Dosing

Cimetidine is available as Tagamet HB. In children and adults, the recommended injectable dosage is 150mg/ml whereas the oral solution is 300mg/5ml. The drug also comes in 300 mg, 200 mg, 800 mg (Rx), 600 mg (Rx), and 400mg (Rx) tablets.
For duodenal ulcers, Cimetidine should be used if the potential advantages surpass the risks involved for children below 16 years. The recommended dosage consideration for this group is 20-40mg/kg administered orally or intravenously every day in 6-hour intervals.
Cimetidine is not the most appropriate choice of drug for use amongst the elderly, especially due to potential drug interactions and confusion. However, for benign gastric and duodenal ulcers, administer 800 mg of Cimetidine once per day, or 400 mg taken orally every 12 hours or 300 mg taken orally every 6 hours orally. For erosive GERD, administer 800mg of cimetidine in a single daily dose or 400 mg taken orally every 12 hours.
In the event of an overdose, one should seek emergency medical attention. Symptoms associated with an overdose may include extreme weakness, fainting confusion, diarrhea, vomiting or nausea.

Mechanism of Action

Cimetidine inhibits the secretion of acid in the stomach, and it is taken orally or intravenously. It belongs to histamine-2 (H2) drug class suppressors which also include famotidine, nizatidine, and ranitidine. Histamine is a naturally occurring substance that influences acid production in parietal cells located in the stomach. H2-blockers suppress histamine activity on the cells, which decreases acid production by the stomach. When acid production in the stomach is relatively high, the stomach lining, the duodenum and the esophagus can be affected negatively, which may also result in ulceration and inflammation. Therefore, minimizing the rate of acid production by the stomach allows for ulcers and acid-induced inflammation to heal. The drug is also approved by the FDA.

Interactions

Severe drug interactions associated with cimetidine include terfenadine, pimozide, lomitapide, eliglustat, dofetilide, cisapride and astemizole. However, if a patient is advised by their pharmacist or doctor to use this medication, then there could be a possibility that they are aware of potential drug interactions. Therefore, one should not discontinue or adjust the dosage of any drugs without consulting their healthcare practitioner.
Cimetidine has mild, moderate and adverse drug interactions with 69, 193 and 143 medical drugs respectively. Medications other than the ones highlighted above may have negative interactions with cimetidine.

Side Effects

Minor side effects associated with cimetidine include fatigue, nausea, headache, vomiting, muscle pain, insomnia, diarrhea and constipation. Adverse side effects in may consist of hallucinations and confusion in critically ill or geriatric patients, breast enlargement, impotence especially after prolonged use of high doses, and a reduction in white blood cell count.
Other side effects may include hepatitis, allergic reactions, visual changes, skin rash and irregular heartbeat.
One should consult their doctor if they experience an irregular heartbeat, dizziness, abdominal pain, crusting or bleeding sores on the lips, mental or mood changes, signs of infection such as swollen glands, sore throat or chills, liver problems such as yellowing of the skin and dark urine, and swelling of the limbs.

Warnings

This drug contains cimetidine hence one should not ingest Tagamet HB if they are hypersensitive to the drug or its constituents. Cimetidine should be kept out of reach of children.
Cimetidine is an antiandrogen hence it may result in sexual dysfunction and feminization in men. The drug is considered safe for use amongst pregnant women, but since it can be absorbed into breast milk, lactating mothers should refrain from Cimetidine.
People with kidney or liver disease may be at a higher risk of experiencing intense side effects if Cimetidine is administered without appropriate advice from a medical practitioner. The doctor should indicate how the drug may influence the pre-existing liver or kidney disease, and whether the patient may require additional monitoring.

References

https://www.drugbank.ca/drugs/DB00501
https://en.wikipedia.org/wiki/Cimetidine

Chemical Properties

White Solid

Uses

antibacterial

Uses

Competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output

Definition

ChEBI: A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H -receptor antagonist that inhibits the production of acid in stomach.

brand name

Tagamet (GlaxoSmithKline).

General Description

White crystals with a slight sulfur-mercaptan odor.

Air & Water Reactions

Slightly water soluble.

Fire Hazard

Flash point data for Cimetidine are not available. Cimetidine is probably combustible.

Biological Activity

Widely used H 2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I 1 imidazoline binding site ligand.

Cimetidine Preparation Products And Raw materials

Raw materials

Preparation Products


Cimetidine Suppliers

Global( 284)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22059 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2549 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Jinan Tenglong Chemical Co.,Ltd
Whatsapp:+8615563263311 Skype:live:smions7080
smions7080@gmail.com CHINA 778 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20001 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3624 58
Wuhan HongxinKang Fine Chemical Co., Ltd. 027-59362599 18674037007
027-84802889 zhuoxingwc@163.com China 942 58

View Lastest Price from Cimetidine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-04-12 Cimetidine
51481-61-9
US $10.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.
2018-12-25 Cimetidine
51481-61-9
US $1.00 / kg 1g 99% 100KG career henan chemical co

Cimetidine Spectrum


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