Tetrazole
- CAS No.
- 288-94-8
- Chemical Name:
- Tetrazole
- Synonyms
- 1H-TETRAZOLE;2H-TETRAZOLE;1,2,3,4-tetrazole;1H-1,2,3,4-TETRAZOLE;1H-1,2,3,4-TETRAAZOLE;TETRAZOLE;1tetrazole;1H-Tertazole;1H-Tetraazole;Tetrazole,98%
- CBNumber:
- CB4230898
- Molecular Formula:
- CH2N4
- Molecular Weight:
- 70.05
- MDL Number:
- MFCD00005247
- MOL File:
- 288-94-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Tetrazole solution for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile | 88185 | 100ml | $195 |
| Tetrazole solution for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile | 88185 | 500ml | $881 |
| 1H-Tetrazole (~0.45M in Acetonitrile) Asreported | 412433 | 200ml | $542 |
| 1H-Tetrazole (~0.3M in Acetonitrile) | TRC-T307505-50ML | 50mL | $192 |
| 1H-Tetrazole (~0.3M in Acetonitrile) | TRC-T307505-25ML | 25mL | $123 |
| More product size | |||
| Melting point | 156-158°C |
|---|---|
| Boiling point | 220℃ |
| Density | 0.798 g/mL at 20 °C |
| RTECS | UW7370000 |
| refractive index |
n |
| Flash point | 5 °C |
| storage temp. | Room temperature. |
| solubility | DMSO, Methanol |
| form | Liquid |
| pka | 4.9(at 25℃) |
| color | Cream to orange |
| Water Solubility | Soluble |
| Decomposition | 220°C |
| BRN | 105799 |
| Stability | Stable at RT |
| InChI | 1S/CH2N4/c1-2-4-5-3-1/h1H,(H,2,3,4,5) |
| InChIKey | KJUGUADJHNHALS-UHFFFAOYSA-N |
| SMILES | c1nnn[nH]1 |
| CAS DataBase Reference | 288-94-8(CAS DataBase Reference) |
| FDA UNII | D34J7PAT68 |
| NIST Chemistry Reference | 1H-Tetrazole(288-94-8) |
| EPA Substance Registry System | 1H-Tetrazole (288-94-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H303-H312-H225-H302-H319-H332 |
| Precautionary statements | P210-P305+P351+P338-P261-P280-P303+P361+P353-P501a |
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard Codes | F,Xn,E |
| Risk Statements | 11-20/21/22-36-5-4 |
| Safety Statements | 16-26-36-36/37-35-15 |
| RIDADR | UN 0504 |
| WGK Germany | 3 |
| F | 3-4.15-10 |
| HazardClass | 1.1D |
| HS Code | 29339900 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2 |
| Limited Quantities | 1.0 L (0.3 gallon) (liquid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) |
Tetrazole price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 88185 | Tetrazole solution for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile | 288-94-8 | 100ml | $195 | 2026-04-30 | Buy |
| Sigma-Aldrich | 88185 | Tetrazole solution for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile | 288-94-8 | 500ml | $881 | 2026-04-30 | Buy |
| Usbiological | 412433 | 1H-Tetrazole (~0.45M in Acetonitrile) Asreported | 288-94-8 | 200ml | $542 | 2026-06-03 | Buy |
| TRC | TRC-T307505-50ML | 1H-Tetrazole (~0.3M in Acetonitrile) | 288-94-8 | 50mL | $192 | 2026-06-03 | Buy |
| TRC | TRC-T307505-25ML | 1H-Tetrazole (~0.3M in Acetonitrile) | 288-94-8 | 25mL | $123 | 2026-06-03 | Buy |
Tetrazole Chemical Properties,Uses,Production
Description
Tetrazole is a class of synthetic organic heterocyclic compound containing a 5-member ring of four nitrogen atoms and one carbon atom. It appears as an odorless white to light-yellow crystalline powder. It has several pharmaceutical applications. Tetrazole compound can act as a bioisotere for the carboxylate group, angiotensin II receptor blockers such as losartan and candesartan as well as dimethyl thiazolyl diphenyl tetrazolium bromide (MTT), which can be used in MTT assay for quantifying the respiratory activity of liver cells. It can also be used in DNA assays. In addition, Tetrazole derivatives have also been used in explosives such as TNT or high performance solid rocket propellant formulations. Tetrazole can be synthesized through the reaction between anhydrous hydrazoic acid and hydrogen cyanide under pressure.
References
https://en.wikipedia.org/wiki/Tetrazole
https://pubchem.ncbi.nlm.nih.gov/compound/1H-Tetrazole#section=Information-Sources
Chemical Properties
white crystals or crystalline powder
Uses
Tetrazole is a catalyst for phosphoramidite synthesis. It is also used as an intermediate for the drug cilostazol. Cilostazol is an antiplatelet drug and a vasodilator. Tetrazole derivatives are used as antibiotics and optically active tetrazole-containing antifungal preparations of azole type was reported.
Preparation
The first tetrazole synthesis was reported in 1885.
Tetrazole Synthesis: Nano-TiCl4.SiO2 (0.1 g) was added to a mixture of benzonitrile (1 mmol), sodium azide (2 mmol) in DMF (5 mL) at reflux for 2 h. After completion of reaction (as monitored by TLC), the mixture was allowed to cool to room temperature, the catalyst was removed by filtration. Then by adding ice water and 4N HCl (5 mL) to the residue, a white solid was obtained. This was then washed with cold chloroform. This simple procedure yielded pure tetrazole with good yields.
Definition
ChEBI: 1H-tetrazole is a tetrazole tautomer where the proton is located on the 1st position. It is a tetrazole and a one-carbon compound. It is a tautomer of a 2H-tetrazole and a 5H-tetrazole.
Application
1H-Tetrazole is used as a bioisostere for the carboxylate group. It is also used as coupling reagent for preparation of polynucleotides.
General Description
Tetrazole is an odorless white to light-yellow crystalline powder. Mp:1 55-157°C. When heated to decomposition Tetrazole emits toxic oxides of nitrogen fumes. Can explode if exposed to shock or heat from friction or fire. The primary hazard is from blast effect where the entire load can explode instantaneously and not from flying projectiles and fragments.
Health Hazard
Fire may produce irritating, corrosive and/or toxic gases.
Fire Hazard
MAY EXPLODE AND THROW FRAGMENTS 1600 meters (1 MILE) OR MORE IF FIRE REACHES CARGO.
Purification Methods
Crystallise the tetrazole from EtOH and sublime it under high vacuum at ca 120o (care should be taken due to possible EXPLOSION). [Beilstein 26 H 346, 26 I 108, 26 II 196, 26 III/IV 1652.]
Tetrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Allgreen Chemical Co.,LTD | +86-37155567971 +86-13633837469 | info@allgreenchem.com | China | 5998 | 58 |
| SHANGHAI YOUNG-CHEM CHEMICAL CO., LTD. | +8613817489192 | hebe@ychemchemical.com | China | 2435 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| XINXIANG RUNYU MATERIAL CO., LTD. | +86-13592593621; +8613592593621 | sales@runvmat.com | China | 459 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Shandong Juchuang Chemical Co., LTD | +16837774622 | admin@juchuangchem.com | China | 295 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
Related articles
- Tetrazole: Novel Building Blocks for Drug
- Tetrazole is widely utilized as a bioisostere for carboxylic acid in the field of medicinal chemistry and drug development.
- May 7，2025
View Lastest Price from Tetrazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-03-20 | Tetrazole
288-94-8
|
$1.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-23 | Tetrazole
288-94-8
|
1kg | 99% | 500kg | XINXIANG RUNYU MATERIAL CO., LTD. | ||
 |
2025-06-27 | Tetrazole
288-94-8
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
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