METOCLOPRAMIDE HCL

METOCLOPRAMIDE HCL Properties

Melting point	171-173°C
storage temp.	2-8°C
solubility	H₂O: soluble
form	solid
color	white
NCI Dictionary of Cancer Terms	Reglan
FDA UNII	7B1QZY5SWZ
NCI Drug Dictionary	Reglan

Pharmacokinetic data

Protein binding	13-22%
Excreted unchanged in urine	20-30%
Volume of distribution	3.5(L/kg)
Biological half-life	4-6 / 15

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Xn

Risk Statements

22-36/37/38

Safety Statements

26-36

WGK Germany

3

RTECS

BZ3325000

HS Code

29242990

NFPA 704

	0
2		0

METOCLOPRAMIDE HCL price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M0763	Metoclopramide hydrochloride solid	7232-21-5	10g	$69.6	2024-03-01	Buy
Sigma-Aldrich	M0763	Metoclopramide hydrochloride solid	7232-21-5	25g	$156	2024-03-01	Buy
Sigma-Aldrich	BP357	Metoclopramide hydrochloride British Pharmacopoeia (BP) Reference Standard	7232-21-5	100MG	$219	2023-06-20	Buy
Alfa Aesar	J61545	Metoclopramide hydrochloride	7232-21-5	10g	$50.8	2023-06-20	Buy
Alfa Aesar	J61545	Metoclopramide hydrochloride	7232-21-5	25g	$112	2023-06-20	Buy

Product number	Packaging	Price	Buy
M0763	10g	$69.6	Buy
M0763	25g	$156	Buy
BP357	100MG	$219	Buy
J61545	10g	$50.8	Buy
J61545	25g	$112	Buy

METOCLOPRAMIDE HCL Chemical Properties,Uses,Production

Description

Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT₃ antagonist with K_i and IC₅₀ values of 995 and 308 nM, respectively, in rat cortical membranes. It is also a dopamine D₂ receptor antagonist (IC₅₀ = 483 nM in rat brain synaptic membranes). Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED₅₀ values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (K_is = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents.

Chemical Properties

White Solid

Originator

Primperan,Delagrange,France,1964

Uses

A D2DR inhibitor and an HTR3E inhibitor

Uses

Antiemetic;5-HT3 antagonist

Uses

Dopamine D2 receptor antagonist. Antiemetic.

Manufacturing Process

The N-(diethylaminoethyl)-2-methoxy-4-aminobenzamide used as the starting material may be prepared from o-toluidine. The o-toluidine is initially nitrated with nitric acid to produce 4-nitro-o-toluidine. The 4-nitro-o-toluidine is then converted to 2-hydroxy-4-nitrotoluene by heating with nitrous acid. By reacting the resulting 2-hydroxy-4-nitrotoluene with dimethyl sulfate, 2- methoxy-4-nitrotoluene is formed. The 2-methoxy-4-nitrotoluene is oxidized with potassium permanganate to produce 2-methoxy-4-nitrobenzoic acid. The latter substituted benzoic acid is treated with thionyl chloride to form 2- methoxy-4-nitrobenzoyl chloride. A methyl ethyl ketone solution of the 2- methoxy-4-nitrobenzoyl chloride is added over a period of about 1? hours to a methyl ethyl ketone solution containing an equal molecular quantity of N,Ndiethylethylene diamine while stirring and maintaining the temperature between 0°C and 5°C. The N-(diethylaminoethyl)-2-methoxy-4- nitrobenzamide hydrochloride formed precipitates. It is filtered, washed twice with methyl ethyl ketone, dissolved in alcohol, and reduced catalytically in an absolute isopropyl alcohol solution to form N-(diethylaminoethyl)-2-methoxy- 4-aminobenzamide. The base is obtained by precipitating with sodium hydroxide.
80 g (0.3mol) of N-(2-diethylaminoethyl)-2-methoxy-4-aminobenzamide are dissolved in small portions in 150 cc of acetic acid. The mixture is cooled and 45 g (0.45 mol) of acetic anhydride are added, and the solution obtained is heated for two hours on a water bath. After cooling, the solution is decanted into a round-bottomed flask with a stirrer, a thermometer and a tube for introducing the chlorine. It is stirred and the current of chlorine is passed through, the temperature being maintained between 20°C and 25°C. The stirring is continued for one hour after the completion of the absorption of the chlorine.
The mixture obtained is poured into 2 liters of water and the base is precipitated with 30% soda. The precipitated base is extracted with 400 cc of methylene chloride. After evaporation of the solvent, the N-(2- diethylaminoethyl)-2-methoxy-4-acetamino-5-chlorobenzamide formed crystallizes. The melting point is 86°C to 87°C and the yield is 95%.
To obtain the corresponding amino derivative, 109 g of base are heated under agitation in a round-bottomed flask with 300 cc of 35-36% concentrated hydrochloric acid and 600 cc of water. It is heated on a water bath until dissolution is complete, then maintained at boiling point for 90 minutes, cooled, diluted with 1 liter of water, and neutralized with about 350 cc of 30% soda. The N-(2-diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide formed crystallizes, is centrifuged and washed in water. Its melting point is 122°C and the yield is 74%.
To obtain the corresponding dihydrochloride, the base is dissolved in absolute alcohol (3 volumes) and to that solution is added 5 N alcoholic hydrochloric acid. The dihydrochloride precipitates, is centrifuged and washed with alcohol. It is a solid white material, having a melting point of 134°C to 135°C.

Therapeutic Function

Antiemetic

Biochem/physiol Actions

D2 antagonist; 5-HT3 antagonist; antipsychotic; anti-emetic.

Clinical Use

Nausea and vomiting

Veterinary Drugs and Treatments

Metoclopramide has been used in veterinary species for both its GI stimulatory and antiemetic properties. It has been used clinically for gastric stasis disorders, gastroesophageal reflux, to allow intubation of the small intestine, as a general antiemetic (for parvovirus, uremic gastritis, etc.), and an antiemetic to prevent or treat chemotherapy-induced vomiting.

Drug interactions

Potentially hazardous interactions with other drugs
Ciclosporin: increased ciclosporin blood levels.

Metabolism

Metoclopramide undergoes first-pass hepatic metabolism. It is excreted in the urine, about 85% of a dose being eliminated in 72 hours, 20% as unchanged metoclopramide and the remainder as sulfate or glucuronide conjugates, or as metabolites. About 5% of a dose is excreted in faeces via the bile.

METOCLOPRAMIDE HCL Preparation Products And Raw materials

Raw materials

Chlorine

Preparation Products

METOCLOPRAMIDE HCL Suppliers

Global( 192)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou Tengyue Chemical Co., Ltd.	+86-86-18148706580 +8618826483838	evan@tyvovo.com	China	152	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	964	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Shanghai Longyu Biotechnology Co., Ltd.	+8615821988213	info@longyupharma.com	China	2531	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3531	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58

Supplier	Advantage
Guangzhou Tengyue Chemical Co., Ltd.	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58

View Lastest Price from METOCLOPRAMIDE HCL manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-19	METOCLOPRAMIDE HCL 7232-21-5	US $0.00 / kg	1kg	99%	20tons	Shaanxi TNJONE Pharmaceutical Co., Ltd
2023-12-20	Metoclopramide hydrochloride 7232-21-5	US $90.00 / kg	1kg	99% Purity (What/sapp: +86 18145728414)	1000 Tons/Month	Guangzhou Tengyue Chemical Co., Ltd.
2022-11-11	Metoclopramide hydrochloride 7232-21-5	US $0.00-0.00 / kg	1kg	99%-101%	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD

METOCLOPRAMIDE HCL
7232-21-5
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Metoclopramide hydrochloride
7232-21-5
US $90.00 / kg
99% Purity (What/sapp: +86 18145728414)
Guangzhou Tengyue Chemical Co., Ltd.

Metoclopramide hydrochloride
7232-21-5
US $0.00-0.00 / kg
99%-101%
WUHAN FORTUNA CHEMICAL CO., LTD

METOCLOPRAMIDE HCL Spectrum

METOCLOPRAMIDE HCL(7232-21-5)¹HNMR

7232-21-5(METOCLOPRAMIDE HCL)Related Search:

batanopride METOCLOPRAMIDE HCL Cloxacepride 4-AMINO-N-1-AZABICYCLO[2.2.2]OCT-3-YL-5-CHLORO-2-METHOXYBENZAMIDE HYDROCHLORIDE NEMONAPRIDE

Lintopride 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide Metoclopramide hydrochloride 2-METHOXYBENZAMIDE pancopride

Mezacopride PERALOPRIDE Benzamide, 5-chloro-N-(2-(diethylamino)ethyl)-4-((4,5-dihydro-1H-imida zol-2-yl)amino)-2-methoxy- Benzamide, 4-amino-5-chloro-N-(2-(cyclopropylethylamino)ethyl)-2-metho xy- 5-Chloro-N-(2-(diethylamino)ethyl)-4-((4,5-dihydro-2-oxazolyl)amino)-2 -methoxybenzamide

Benzamide, 4-amino-5-chloro-2-methoxy-N-(2-(4-(2-pyridinyl)-1-piperazi nyl)ethyl)- METOCLOPRAMIDE HCL IMP. C (EP):4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID METOCLOPRAMIDE HCL IMP. H (EP): 4-(ACETYLAMINO)-2-HYDROXYBENZOIC ACID

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Metoclopramide hydrochloride ,99% 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide monohydrochloride METOCLOPRAMIDE HCL METOCLOPRAMIDE MONOHYDROCHLORIDE 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamidmonohydrochloride cerucal maxolon paspertin primperan(tablet) reglan 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide monohydrochloride METOCLOPRAMIDE HYDROCHLORIDE 5-HT3 SEROT ONIN ANTAG Benzamide, 4-amino-5-chloro-N-2-(diethylamino)ethyl-2-methoxy-, monohydrochloride METOCLOPRAMIDEHYDROCHLORIDE,ANHYDROUS AKOS 92099 2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethyl)benzamide AHR-3070-C Metoclopramide hydrochloride LABOTEST-BB LT00772087 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxy-benzamidmonohydroch 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamidehydrochloride CloproMate DraclaMid EMperal Eucil Gastrese Gastrobid Gastrosil GastroteM Maxeran Meclopran MetaMide Metoclopramide hydrochloride Solution in Water, 100μg/mL METOCLOPRAMIDE HCL USP/EP/BP Metoclopramide hydrochlorideQ: What is Metoclopramide hydrochloride Q: What is the CAS Number of Metoclopramide hydrochloride Q: What is the storage condition of Metoclopramide hydrochloride Q: What are the applications of Metoclopramide hydrochloride Carbothion opramide (hydrochloride) 7232-21-5 C14H22ClN3O2 C14H22ClN3O2ClH D2 antagonist; 5-HT3 antagonist; antipsychotic; anti-emetic Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals Antagonists Dopaminergics Neurotransmitters Dopamine receptor