SECOBARBITAL
- CAS No.
- 76-73-3
- Chemical Name:
- SECOBARBITAL
- Synonyms
- Evronal;Immenox;Seconal;somosal;Barbosec;Hypotrol;Imesonal;Trisomnin;Somatarax;Immenoctal
- CBNumber:
- CB4238324
- Molecular Formula:
- C12H18N2O3
- Molecular Weight:
- 238.28
- MDL Number:
- MFCD00056088
- MOL File:
- 76-73-3.mol
| Melting point | 98°C |
|---|---|
| Boiling point | 380.88°C (rough estimate) |
| Density | 1.1343 (rough estimate) |
| refractive index | 1.4760 (estimate) |
| Flash point | 11 °C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
| pka | 7.81±0.10(Predicted) |
| Water Solubility | 1.728g/L(24 ºC) |
| EWG's Food Scores | 1 |
| FDA UNII | 1P7H87IN75 |
| ATC code | N05CA06 |
| EPA Substance Registry System | 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylbutyl)-5-(2-propen-1-yl)- (76-73-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P330+P331+P310-P305+P351+P338 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25-36/37/38-25 | |||||||||
| Safety Statements | 36/37-45-26-16 | |||||||||
| RIDADR | UN 1230 3/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | CP9450000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933530000 | |||||||||
| Toxicity | A barbiturate sedative-hypnotic with a long half-life, the abuse of which can lead to tolerance and dependence. The oral LD50 in rats is 125 mg/kg. | |||||||||
| NFPA 704 |
|
SECOBARBITAL Chemical Properties,Uses,Production
Description
Secobarbital (CRM) (Item No. 21707) is a certified reference material categorized as a barbiturate. It extends intoxication and increases withdrawal effects in patients with a family history of alcoholism. Secobarbital is regulated as a Schedule II compound in the United States. Secobarbital (CRM) (Item No. 21707) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Uses
Barbiturates are being widely used as antiepileptics, hypnotics, and anesthetics Controlled substance.
Definition
ChEBI: A member of the class of barbiturates that is barbituric acid in which the hydrogens at position 5 are substituted by prop-2-en-1-yl and pentan-2-yl groups.
brand name
Seconal(Lilly);Seconal sodium;Tuinal.
World Health Organization (WHO)
Secobarbital is a short to intermediate-acting barbiturate which is controlled under Schedule III of the 1971 Convention on Psychotropic Substances. See WHO comment for barbiturates. (Reference: (UNCPS3) United Nations Convention on Psychotropic Substances (III), , , 1971)
Purification Methods
It is purified by dissolving the sodium salt [309-43-3] in 10% HCl which precipitates the acid form that is extracted into Et2O. The extract is dried (Na2SO4) and evaporated. The residue is then purified by repeated crystallisation from CHCl3. [Buchet & Sandorfy J Phys Chem 88 3274 1984, Beilstein 24 III/IV 2013.]
SECOBARBITAL Preparation Products And Raw materials
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