Fluocinonide | 356-12-7

Fluocinonide Properties

Melting point	309 °C
alpha	D +83° (chloroform)
Boiling point	235°C (rough estimate)
Density	1.2001 (estimate)
storage temp.	2-8°C
solubility	DMSO: ≥19mg/mL
pka	12.77±0.70(Predicted)
form	powder
color	white to tan
optical activity	[α]/D +75 to +90°, c = 1 in dichloromethane
Water Solubility	0.53mg/L(25 ºC)
InChIKey	WJOHZNCJWYWUJD-IUGZLZTKSA-N
FDA UNII	2W4A77YPAN
NCI Drug Dictionary	Lidex
ATC code	C05AA11,D07AC08

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H300-H361

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1/PG 2

WGK Germany

3

RTECS

TU3831000

HazardClass

6.1(a)

PackingGroup

I

HS Code

2937220000

Toxicity

guinea pig,LD50,subcutaneous,> 3170mg/kg (3170mg/kg),Drugs in Japan Vol. 6, Pg. 694, 1982.

NFPA 704

	0
4		0

Fluocinonide price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0099	Fluocinonide ≥98% (HPLC)	356-12-7	10mg	$131	2024-03-01	Buy
Sigma-Aldrich	BP489	Fluocinonide British Pharmacopoeia (BP) Reference Standard	356-12-7	100MG	$257	2024-03-01	Buy
Cayman Chemical	23803	Fluocinonide ≥98%	356-12-7	5mg	$40	2024-03-01	Buy
Cayman Chemical	23803	Fluocinonide ≥98%	356-12-7	10mg	$72	2024-03-01	Buy
Sigma-Aldrich	SML0099	Fluocinonide ≥98% (HPLC)	356-12-7	50mg	$527	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0099	10mg	$131	Buy
BP489	100MG	$257	Buy
23803	5mg	$40	Buy
23803	10mg	$72	Buy
SML0099	50mg	$527	Buy

Fluocinonide Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Topsyn ,Recordati,Italy,1970

Uses

Glucocorticoid; anti-inflammatory.

Uses

Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.

Definition

ChEBI: Fluocinonide is an organic molecular entity.

Indications

Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.

Manufacturing Process

To a suspension of 500 mg of 6α-fluoro-triamcinolone in 75 ml of acetone is added 0.05 milliliters of 72% perchloric acid and the mixture agitated-at room temperature for 3 hours. During this period the crystals gradually dissolve and the clear solution is neutralized with dilute bicarbonate and the acetone removed in vacuo. The resulting crystalline suspension is filtered and the crystals washed with water. The dried material is recrystallized from 95% alcohol to give the pure acetonide.
A solution of 50 mg of 6α-fluoro-triamcinolone acetonide in 1 ml of pyridine and 1 ml of acetic anhydride is allowed to stand at room temperature for 18 hours. Removal of the reagents in vacuo gives a crystalline residue which after crystallization from acetone-hexane gives the pure 16α,17α- isopropylidene 6α-fluoro-triamcinolone 21 acetate (fluocinonide), as described in US Patent 3,197,469.

brand name

Lidex (Medicis); Vanos (Medicis).

Therapeutic Function

Antiinflammatory, Glucocorticoid

Biochem/physiol Actions

Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.

Fluocinonide Preparation Products And Raw materials

Raw materials

6-alpha,9-alpha-difluoro-11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione PERCHLORIC ACID Acetone Acetic anhydride

Preparation Products

Fluocinonide Suppliers

Global( 404)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
Henan Tengmao Chemical Technology Co. LTD	+8615238638457	salesvip2@hntmhg.com	China	415	58
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +8613795318958	bj1@bj-chem.com	China	298	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Henan Tengmao Chemical Technology Co. LTD	58
Shanghai Bojing Chemical Co.,Ltd.	55
Henan Tianfu Chemical Co.,Ltd.	55
Hubei XinRunde Chemical Co., Ltd.	55
career henan chemical co	58
Hebei Guanlang Biotechnology Co., Ltd.	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from Fluocinonide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-02-28	Fluocinonide 356-12-7	US $110.00-90.00 / kilogram	1kilogram	99%	10 tons/per week	Henan Tengmao Chemical Technology Co. LTD
2023-09-06	Fluocinonide 356-12-7	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-03-06	Fluocinonide 356-12-7	US $40.70 / Kg/Bag	10g	99%	10000kg	Hebei Guanlang Biotechnology Co,.LTD

Fluocinonide
356-12-7
US $110.00-90.00 / kilogram
99%
Henan Tengmao Chemical Technology Co. LTD

Fluocinonide
356-12-7
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Fluocinonide
356-12-7
US $40.70 / Kg/Bag
99%
Hebei Guanlang Biotechnology Co,.LTD

Fluocinonide Spectrum

Fluocinonide(356-12-7)¹HNMR

356-12-7(Fluocinonide)Related Search:

fluocinolone16,17-acetonide Triamcinolone acetonide Fluocinolone Acetonide-21-carboxylic Acid 6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate 21-Acetyl-6β-fluorotriamcinolone Acetonide

9beta,11beta-epoxy-6alpha-fluoro-21-hydroxy-16alpha,17-(isopropylidene)dioxypregna-1,4-diene-3,20-dione Fluocoutolone Hexanoate 6-alpha-fluoro-21-hydroxy-16-alpha,17-alpha-isopropylidenedioxypregn-4-ene-3,20-dione (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-carboxylic Acid Fluocinolone Acetonide-21-aldehyde

6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate) Fluocinolone Acetonide Impurity 4 9beta,11beta-epoxy-6alpha-fluoro-21-hydroxy-16alpha,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione 21-acetate FLURANDRENOLONE ACETATE Fluocinolone

(6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-21-Methoxy-16,17-[(1-Methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione Fluocinolone Acetonide Impurity 2 9a-Fluoro-11, 6a, 17a, 21-Tetrahydroxy-Pregna-4-ene-3, 20-Dione

1of4

Cortalar Gelisyn Lidemol Fluocinonide (100 mg) Fluocinonide(Vanos) (6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione Flucetonide Fluocinonide Solution, 100ppm Lonide 1,4-PREGNADIEN-6-ALPHA, 9-ALPHA-DIFLUORO-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE 21-ACETATE FLUOCINOLONE ACETONIDE 21-ACETATE FLUOCINOMIDE FLUOCINONIDE FLUOCINONIDE ACETONIDE 21-ACETATE droxy-,cyclic17-acetalwithacetone,21-acetate pregna-1,4-diene-3,20-dione,6-alpha,9-difluoro-11-beta,16-alpha,17,21-tetrahy topsym Fluocinoide acetonide FLUOCINONIDE,MICRONIZED,USP Biscosal Lidex NSC 101791 Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)- Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-acetate (7CI, 8CI) Straderm Topsymin Topsyn Topsyne pregna-1,4-diene-3,20-dione, 6-alpha, 9-difluoro-11-beta,16-alpha,17,21-tetrahy droxy-, cyclic 17-acetal with acetone, 21-acetate flucinar fluocinolide fluocinolide acetate fluocinolone acetonide 21-acetate fluocinolone acetonide acetate fluocinonide lidex e Fluocinonide acetate 21-Acatyloxy-6,9-diflulro-11-hydroxy-16,17-[(1-methyl-ethylidene)bis(oxy)]pregna-1,4-di-ene-3,20-dione Fluocinonide, Micronized flucinar fluocinolideacetate fluocinoloneacetonideacetate Fluocinonideacetate lidexe metosyn 2-chloroethoxy(diphenyl)phosphine Fluocinonide RS Fluocinolone Acetonide Impurity 13 (Fluocinolone Acetonide EP Impurity M）(Fluocinonide) Fluorocarbon acetate Fluocinonide USP/EP/BP FluocinonideQ: What is Fluocinonide Q: What is the CAS Number of Fluocinonide Q: What is the storage condition of Fluocinonide Q: What are the applications of Fluocinonide 6α,9-Difluoro-11β-hydroxy-16α,17-(1-methylethylidenedioxy)-3,20-dioxopregna-1,4-dien-21-yl Acetate Fluocinonide (1276001) Vanos fluocinolide Fluocinolone Acetonide EP Impurity M Fluocinonide Acetonide Fluoxetine acetate Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)- 1, 4-PREGNADIEN-6α, 9α-DIFLUORO-11β, 16α, 17, 21-TETROL-3, 20-DIONE 16, 17-ACETONIDE 21-ACETATE Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(6a,11b,16a)- 356-12-7 C26H32F2P7 FA - FL Analytical Chromatography Product Catalog Alphabetic Analytical Standards