(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one
- CAS No.
- 126860-83-1
- Chemical Name:
- (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one
- Synonyms
- MC-1046;24-carbonyl-Calcipotriol;IMpurity A of Calcipotriol;Calcipotriol EP Impurity A: Ketone analog;Calcipotriol Impurity 1(Calcipotriol EP Impurity A);(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one;(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one;(5Z,7E,22E)-24-Cyclopropyl-1α,3β-dihydroxy-9,10-secochola-5,7,10 (19),22-tetraen-24-one;(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one;(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one (90%)
- CBNumber:
- CB42414777
- Molecular Formula:
- C27H38O3
- Molecular Weight:
- 410.59
- MDL Number:
- MFCD00872035
- MOL File:
- 126860-83-1.mol
| Boiling point | 584.2±50.0 °C(Predicted) |
|---|---|
| Density | 1.12±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light, stored under nitrogen,unstable in solution, ready to use. |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 14.43±0.40(Predicted) |
| FDA UNII | G70BS4HF9Z |
(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C988310 | (1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one(90%) | 126860-83-1 | 0.25mg | $305 | 2021-12-16 | Buy |
| ChemScene | CS-1162 | MC1046 | 126860-83-1 | 1mg | $500 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 68944 | (1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one(90%) | 126860-83-1 | 0.25mg | $750 | 2021-12-16 | Buy |
| ApexBio Technology | A3588 | MC1046 | 126860-83-1 | 1mg | $1339 | 2021-12-16 | Buy |
(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Chemical Properties,Uses,Production
Uses
MC 1046 is a vitamin D3 analogue with similar effects. Impurity of Calcipotriol (C144200), an antipsoriatic.
Biological Activity
mc 903 has been found to be a potent inducer of cell differentiation and to inhibit proliferation and dna-synthesis of cells possessing the receptor for 1,25(oh)2d3. mc 1046 is the metabolite of calcipotrioi (mc 903), which is a novel analogue of the physiologically active metabolite of vitamin d3.
in vitro
the biological effects on the u937 cells of the two major metabolites of mc 903 (mc 1046 and mc 1080) were investigated. results showed that the metabolites had effects that were more than 100 times weaker than those of the parent compound [1].
in vivo
mc 903 is a novel analogue of the physiologically active metabolite of 1,25(oh)2d3. unlike the similar effects on cell proliferation and cell differentiation in vitro, mc 903 has 100-200 times less effect on calcium metabolism in vivo. moreover, rat study indicats that the effect of mc 903 on proliferative disorders, its fast elimination and the formation of inactive metabolites makes mc 903 suitable for topical treatment of psoriasis [1].
References
[1] kissmeyer am, binderup l. calcipotriol (mc 903): pharmacokinetics in rats and biological activities of metabolites. a comparative study with 1,25(oh)2d3. biochem pharmacol. 1991;41(11):1601-6.
(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 +86-13986145403 | info@fortunachem.com | China | 5984 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
View Lastest Price from (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-01 | MC 1046
126860-83-1
|
US $0.00 / KG | 1KG | 98%min | 30tons | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2020-03-06 | (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one
126860-83-1
|
US $1.00 / KG | 1KG | 97%-99.9% | 200kg | Career Henan Chemical Co |
-
- MC 1046
126860-83-1
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one
126860-83-1
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co