PF 573228
- CAS No.
- 869288-64-2
- Chemical Name:
- PF 573228
- Synonyms
- PF-228;CS-253;PF 573228;PF-573228, >=98%;PF-573228;PF 573228;PF 573228 USP/EP/BP;PF-573228 DISCONTINUED;Focal Adhesion Kinase Inhibitor II;PF-573228 PF573228 Focal Adhesion Kinase Inhibitor II;Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem
- CBNumber:
- CB42459138
- Molecular Formula:
- C22H20F3N5O3S
- Molecular Weight:
- 491.49
- MDL Number:
- MFCD11519967
- MOL File:
- 869288-64-2.mol
- MSDS File:
- SDS
PF 573228 price More Price(41)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PZ0117 | PF-573228 ≥95% (HPLC) | 869288-64-2 | 5mg | $147 | 2024-03-01 | Buy |
Sigma-Aldrich | 324878 | Focal Adhesion Kinase Inhibitor II | 869288-64-2 | 10mg | $233 | 2022-05-15 | Buy |
Cayman Chemical | 14924 | PF-573228 ≥95% | 869288-64-2 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 14924 | PF-573228 ≥95% | 869288-64-2 | 5mg | $100 | 2024-03-01 | Buy |
Sigma-Aldrich | PZ0117 | PF-573228 ≥95% (HPLC) | 869288-64-2 | 25mg | $576 | 2024-03-01 | Buy |
PF 573228 Chemical Properties,Uses,Production
Description
Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively. It is 50-250-fold selective for FAK over other protein kinases. PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.
Uses
A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells.
Definition
ChEBI: 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-3,4-dihydro-1H-quinolin-2-one is a member of quinolines.
Biochem/physiol Actions
PF-573228 is a focal adhesion kinase (FAK) inhibitor; Non-receptor tyrosine kinase inhibitor.
storage
Store at +4°C
References
[1]. slack-davis, j.k., et al., cellular characterization of a novel focal adhesion kinase inhibitor. j biol chem, 2007. 282(20): p. 14845-52.
[2]. golubovskaya, v.m., focal adhesion kinase as a cancer therapy target. anticancer agents med chem, 2010. 10(10): p. 735-41.
[3]. cabrita, m.a., et al., focal adhesion kinase inhibitors are potent anti-angiogenic agents. mol oncol, 2011. 5(6): p. 517-26.
[4]. al-toub, m., et al., pleiotropic effects of cancer cells' secreted factors on human stromal (mesenchymal) stem cells. stem cell res ther, 2013. 4(5): p. 114.
[5]. so, e.c., et al., evidence for activation of bk ca channels by a known inhibitor of focal adhesion kinase, pf573228. life sci, 2011. 89(19-20): p. 691-701.
PF 573228 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29831 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Aceschem Inc. | +1-817863-6948 +1-(817)863-6948 | sales@aceschem.com | United States | 19639 | 58 |
View Lastest Price from PF 573228 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-01-09 | PF 573228;3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
869288-64-2
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
- PF 573228;3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
869288-64-2
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co